rok 2006 - Fakulta chemickej a potravinárskej technológie ...
rok 2006 - Fakulta chemickej a potravinárskej technológie ...
rok 2006 - Fakulta chemickej a potravinárskej technológie ...
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Project duration: from <strong>2006</strong> to 2008<br />
Q. APVV project LPP-0234-06, Chromatographic separation of fruktooligosaccharides (Milan<br />
Polakovič)<br />
This project is carried within a programme aimed at the stimulation and support of excellent PhD. supervisors.<br />
The content of the project is associated with the education of a PhD. student having the topic of the PhD. study<br />
identical with the title of the project.<br />
Project duration: from 13.11. <strong>2006</strong> to 31.11.2009<br />
R. VEGA project 1/3582/06, Mechanisms and kinetics of enzyme inactivation (Vladimír<br />
Štefuca)<br />
Enzyme inactivation is a phenomenon, which has unfavorable impact in various areas, such as biocatalytic<br />
productions, food processing or application of diagnostic tests. A way to the increase of process stability of<br />
enzymes can be a better understanding of their inactivation mechanisms. The primary goal of this project is the<br />
investigation of the mechanism of heat and pH inactivation of enzymes in real media, in which the effect of<br />
stabilization of enzymes by components of the solution is manifested. The method of identification of inactivation<br />
mechanisms is based on a consequent connection of the design of experiments, its performance under a broad<br />
range of conditions and evaluation of the kinetics by mathematical modeling. In special cases, the investigation of<br />
the mechanism of inactivation will be based on a combined treatment of kinetic data of the loss of enzyme activity<br />
and quantities characterizing structural changes, as intensity of laser light scattering or molecular weight<br />
distribution obtained by electrophoresis or chromatography. The methods of the investigation of mechanisms are<br />
directly related to the elaboration of a procedure for quick determination of process stability of an immobilized<br />
biocatalyst in a differential fixed bed reactor.<br />
Project duration: from 01.01. <strong>2006</strong> to 31.12.2008<br />
S. VEGA project 1/3565/06, Engineering aspects of chromatographic separation of proteins<br />
and saccharides (Milan Polakovič)<br />
The project deals with the investigation of engineering aspects of chromatographic separation of a mixture of<br />
proteins and saccharides, which are subject of practical interest. Particularly, the purification of IgG,<br />
fructosyltransferase (FTase) and fructooligosaccharides (FOS’s) has been studied. A problem of general interest<br />
is the investigation of the accessibility of pores by batch and column size-exclusion techniques. The aim is the<br />
assessment of advantages, disadvantages and limitations of both techniques and the possibility of interpretation<br />
of basic data in the form of pore size distribution. A further part of the project includes investigation of equilibrium<br />
and kinetics of adsorption of proteins on affinity and ion-exchange adsorbents by a batch method. The<br />
investigation of multi-component adsorption equilibria of saccharides on ion-exchangers will be one of the<br />
important parts of the project for their further utilization for modeling and designing separation in a simulated<br />
moving bed. In the area of separation of enzymes the project will be aimed at characterizing equilibria in various<br />
concentrations of salts, which can be employed in mathematical description of separation using salt gradient. The<br />
last area of interest will concern the investigation of kinetics of affinity sorption of FTase on an adsorbent with a<br />
bound lectin ligand.<br />
Project duration: from 01.01. <strong>2006</strong> to 31.12.2008<br />
V. CURRENT EDUCATION PROJECTS<br />
ACU/2005/04/AF/02 A laboratory for testing construction materials for Herat University<br />
(Haydary Juma)<br />
The project’s objective is to contribute to the improvement of quality of higher engineering education in<br />
Afghanistan. The major part of the project is implementation of a laboratory for the testing of construction<br />
materials at the Herat University and a training program for teachers, who will manage the laboratory. The overall<br />
project outcomes can be formulated as: long-term cooperation between the Herat University and the Slovak<br />
University of technology, improvement of the education process and the knowledge and skill of engineering<br />
graduates, improvement of knowledge and skill of the teachers of the Faculty of engineering of HU, and increase<br />
of the quality and safety of buildings which will be constructed in the region.<br />
Project duration: from 2005 to 2007<br />
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