rok 2006 - Fakulta chemickej a potravinárskej technológie ...

APVT Project No 20-003904 Biochemical and genetic aspects of senescence and cell death of
filamentous fungi (Boris Lakatoš)
In this project the biochemical and genetic mechanisms of senescence of filamentous fungi will be studied in
context with their physiological functions, in particular conidiation and intrahyphal differentiation, in respect of
possible utilization of this process in biotechnology. In the project a unique and never before used complex of
experimental models combined of wild strains and mutants defective in conidiation will be used in combination
with different cultivation conditions. Their simultaneous analysis will enable to solve general aspects of
senescence in filamentous fungi.
Project duration: from 01.01.2005 to 31.12.2007
Vega Project No 1/2335/05 The role of proton-motive force in the Ca2+ homeostasis in
filamentous fungi (Martin Šimkovič)
Ca2+ homeostasis represents an integrating system of every living cell and plays a crucial role in the regulation of
numerous functions on both cellular and organism levels. There is only scarce knowledge on the Ca2+
homeostasis in filamentous fungi, which are scattered among several fungal species. Recently, we described
properties of partial reactions of Ca2+ homeostasis and their developmental changes in deuteromycete
Trichoderma viride. We found that uncouplers stimulated both Ca2+ influx and efflux across the cytoplasmic
membrane. This means that the electrochemical potential of H+ couples Ca2+ translocation across this
membrane. This observation is important for the understanding of Ca2+ homeostasis and opens new views on
the physiology of fungi and its intentional manipulation. This project is mainly devoted to the analysis of this
phenomenon, to ascertaining its universality and/or specificity. A part of this project will be devoted to
experiments, which could elucidate the role of Ca2+ in the signaling pathway triggering the light-induced
conidiation in Trichoderma viride.
Project duration: from 01.01.2005 to 31.12.2007
V._CURRENT EDUCATION PROJECTS
VI._COOPERATION
A._Cooperation in Slovakia
Institution Type of cooperation Responsible person Duration
Institute of
Molecular
Physiology and
Genetics, SAS,
Bratislava
Cancer Research
Institute, SAS,
Bratislava
Tissue Bank,
Hospital Ružinov,
Bratislava
Dept. of Chem.
Theory of Drugs,
Fac. of Pharmacy,
Comenius
University,
Bratislava
Institute of
Chemistry, Faculty
of Science, PJŠU,
Košice
Characterisation of basal Ca2+
transport in non-excitable cells ( Joint
grant)
Cytotoxicity of Novel Xenobiotics and
Their mode of Action
Cultivation and growth of human and
animal tissue cultures on new
biomaterials
Study of antimicrobial activity of newly
synthesized copper complexes
New coordinating compounds of zinc,
their preparation, study of physicochemical
properties and their
biological activity (Joint grant)
Dr. Jozef Orlický, Senior
Research Scientist, Vlárska
5, 833 34 Bratislava
Dr. Darina Slameňová, Head
of Group, Vlárska 7, 833 91
Bratislava
Dr. Jana Dragúňová,
Ružinovská 6, 826 06
Bratislava
Dr. Aladár Valent, Associate
professor, Kalinčiakova 8,
832 32 Bratislava
Prof. Katarína Gyoryová, Full
Professor, Moyzesova 11,
040 01 Košice
01.01.1990 -
01.01.1991 -
01.01.1998 -
01.01.1999 -
01.10.2001 -
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