rok 2006 - Fakulta chemickej a potravinárskej technológie ...

L. VEGA Project No 1/3581/06, Specification of prediction of multi-component vapor-liquid and
liquid-liquid equilibria for the purpose of separation of liquids by distillation, extraction and
extractive distillation (Elena Graczová)
Specification of prediction of two-phase multi-component vapor-liquid and liquid-liquid equilibria necessary for the
design of industrial separation equipment like distillation and extraction columns, and for the estimation of
optimum operation conditions. Extension of the method of correlation of three-component equilibrium data of twophase
systems (vapor-liquid and liquid-liquid) by the universal ternary contribution. Investigation of the influence
of the ternary correction evaluated from ternary vapor-liquid equilibrium data and combined vapor-liquid and
liquid-liquid data for obtaining more precise prediction of a complex two-phase four-component equilibrium.
Application of the calculation for systems related to the separation of BTX aromatics with mixed extraction
solvents.
Project duration: from 01.2006 to 12. 2008
M. LPP-0181-06 Modelling of reactive separation processes (Jozef Markoš)
Modelling of reactive separation processes. Industrial processes involving chemical reaction and separation in
one unit are called reactive separations. Mathematical modelling of reactive separation units represents a useful
tool for their design, optimization, parametric sensitivity and safety analysis. The main aim of the proposed project
is to develop a non-equilibrium model of a reactive separation unit with very fast reactions in steady state and in
dynamic regime and to apply the developed model for simulation of such units.
Project duration: from 2006 to 2009
N. VEGA-1/3573/06 Modelling, hydrodynamic and oxygen mass transfer in airlift bioreactors
(Jozef Markoš)
Modelling, hydrodynamic and oxygen mass transfer in airlift bioreactors. The use of airlift reactors in
biotechnology becomes more and more extensive. In spite of this fact, most papers published in the literature
deals with the use of ALRs only with model media like air – water. The aim of this project is to study the
hydrodynamics and mass transfer of oxygen in real fermentation air lift bioreactors. With help of a mathematical
model of the reactor and experiments in laboratory ALRs with working volumes of 10, 40 and 200 liters, the
influence of a real fermentation broth on ALR hydrodynamics and scale up will be studied.
Project duration: from 2006 to 2008
O. APVV-99-004405 Study of 2-phenylethanol formation in an integrated system with
continuous product separation (Vladimír Báleš)
The basic aim of the project is the achievement of knowledge on biochemistry of 2-phenylethanol formation by
yeasts cultivated in media with organic phase. Study of the toxic influence of the product on microbial culture and
its elimination by in-situ separation in an external unit will be done. The metabolic activities of selected yeast
strains (Saccharomyces sp., Kluyveromyces sp.) related to the 2-phenylethanol production will be studied.
Cultivation media composition as well as the process parameters will be optimized. To minimize the toxic effects
of the product towards the culture, the mechanism and characteristics of in-situ product extraction during the
fermentation process will be used and studied. A suitable organic phase will be selected and tested for in-situ
extraction of the product. A continuous product separation system will be constructed and integrated into the
system bioreactor - in-situ extraction - separation. Finally. the integrated process for 2-phenylethanol will be
designed and optimized in lab- and pilot-scale experiments. Optimal parameters of the batch and continuous
processes will be proposed and described. Process data should be used for design of the industrial scale process
for production of 2-phenylethanol.
Project duration: from 01. 03.06 to 31.12. 09
P. APVV-51-033205, Genetically modified microorganisms as whole cells biocatalysts of
enantioselective biooxydations for new immobilized biotechnologies (Vladimír Štefuca)
The project is aimed at the development of immobilized cell biocatalysts for oxidation of prochiral compounds
through the Baeyer-Villiger reaction mechanism. The basic tasks of the Faculty involved are: 1. Development of
an optimum biocatalyst particle using experimental and mathematical modeling involving kinetic and mass
transfer phenomena; 2. Design and scale up of bioreactors for oxidative biotransformations of chosen
compounds.
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