rok 2006 - Fakulta chemickej a potravinárskej technológie ...

and stereoselective transformations of bicyclic tetramic acid derivatives. Utilization of such asymmetric
transformation in the synthesis of natural polysubstituted amino acids and their derivatives. Preparation of 5
aryl¬substituted 3 amino-2-hydroxytetrahydrofurans and study of their conversion to optically pure substituted C-
aryl amino¬furanosides.
Project duration: from 01.01.2005 to 31.12.2007
VEGA project No 1/248/05 Polyazaheterocycles and their oxygen analogues. Ecologically
more suitable syntheses, supramolecular structure, biological – physical properties (Viktor
Milata)
The project aims at preparation of novel aromatic polyazaheterocycles on the bases of triazines, dihydropyridines,
pyrimidines, quinolines and quinazolines, having additional fused aromatic or saturated ring. In the early stages of
the project we shall concentrate on preparation of precursors to the above heterocycles by modern, more
ecological methods. Next the precursors will be used in cyclization and cyclocondensation reaction leading to
target compounds. Prepared heterocycles will be modified to enhance their hydrophilicity and hence bioactivity by
attaching a sugar or other hydrophilic moiety. Our attention will concentrate on physicochemical and spectral
characteristics, combined with xray analysis, supramolecular chemistry and quantum chemical calculations.
Project duration: from 01.01.2005 to 31.12.2007
APVV Project No. 20-007304 Synthesis and properties of the pharmacologically potentially
active nitrogen heterocycles (Viktor Milata)
Study and optimisation of the new synthetic methods for preparation of analogues of natural condensed aromatic
polyazaheterocyclic compounds with fused aromatic or saturated ring containing O, S, Se or N atoms.
Preparation of precursors of cited heterocycles and their nitro- and aminoderivatives, imidoylchlorides, imidoyl
and amidinoylisothiocyanates. Exploitation of new precursors in cyclisation and cyclocondesation reactions for
preparation of target compounds. Derivatisation of newly prepared heterocyclic compounds by introduction of
carbohydrate or other hydrophylic part aiming to higher solubility of prepared compounds allowing their more
effective biological application. Study of physico-chemical properties and spectral characteristics of final
derivatives in relation to their X-ray structural analysis, supramolecular chemistry using quantum-chemical
calculations.
Project duration: from 01.01.2005 to 31.12.2007
APVT Project No. 20-000904 Asymmetric Pd(II)-catalysed reactions as a methodology for the
preparation of chiral bulding blocks for the synthesis of biologically active natural
compounds (Peter Szolcsányi)
The main aim of the project is to develop a new and efficient methodology of asymmetric palladium-catalysed
intramolecular and intermolecular aminocarbonylations and halocyclisations for the enantioselective preparation
of optically pure building blocks. These valuable intermediates will serve as suitable chiral precursors for targeted
total syntheses of biologically active natural compounds and/or their analogues with their potential use in human
medicine. The sub-objectives of the project involve the development of a simple and rapid preparation of
necessary aminoalkenitols as starting substrates in multi-gram quantities and required purity, as well as an
effective synthesis of enantiomerically pure chiral Pd-catalysts essential for key asymmetric transformations.
Project duration: from 01.01.2005 to 31.12.2007
VI. COOPERATION
A. Cooperation in Slovakia
Institution Type of cooperation Responsible person Duration
Synkola, Bratislava
Duslo, Šaľa
Slovak Academy of
Sciences, Bratislava
Seminars and conferences
The synthesis of heterocyclic
compounds.
The synthesis of heterocyclic
compounds.
Karvaš Milan, director, Mlynská dolina,
842 15 Bratislava 4
Lehocký Peter, director, Duslo, a. s.
927 03 Šaľa
Tvaroška Igor, director, Dubravská cesta
9, 841 04 Bratislava 4
01.01.1992-
01.01.1990-
01.01.1970
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