rok 2006 - Fakulta chemickej a potravinárskej technológie ...

stability of food enzymes, the inactivation kinetics of individual enzymes in a broad temperature range and to
carry out the comparative consumer study of food products obtained by conventional and ohmic heating.
Project duration: from 01.03.2004 to 28.02.2006
H. Project FP6-NMP3-CT-2004-500160, Advanced interactive materials by design (AIMs). (Milan
Polakovič)
This integrated project (AIMs) is targeted at the design of a new class of interactive materials composed of
functional elements (ligands) for use in the selective purification steps (i.e. chromatography, membrane
separation, extraction) of pharmaceutical, chemical and bioindustries. A real breakthrough in the optimization of
production processes in these areas requires the integration of material sciences and process development. AIMs
focuses on the production of monoclonal antibodies as an example process. The main objectives in terms of
radical innovation in monoclonal antibodies production are an increase in capacity by a factor of 10 to 50 and a
reduction of cost of goods by a factor of 10 to 100. The STU teams act in one of six subprojects of this integrated
project dealing with the characterization of structural and process parameters of investigated materials and
processes. The role of STU is to determine accessibility of different chromatographic adsorbents by sizeexclusion
techniques, the static adsorption capacity of proteins of interest as well as their dynamics of binding.
Together with other partners, the correlations between structural and performance parameters are made which
are communicated to the partners involved in the material and process design, respectively.
Project duration: from 01.04.2004 to 31.03.2008
I. Project APVT-99-019604, Experimental study of gamma-decalactone production by
microbial biotransformation (Vladimír Štefuca)
The basic aim of the project is the achievement of knowledge necessary for the development of a process of
preparation of gamma-decalactone (GDL) - a bioaroma with high added value, by biotransformation from a
natural precursor. In order to reach this objective, in the first part of the project, it will be necessary to determine
cultivation and biotransformation conditions for a chosen microorganism. The next key task of GDL preparation
will be isolation from the culture medium connected with lactonisation of the intermediate product and purification
to final purity.
Project duration: from 01.01.2005 to 31.12. 2007
J. Project APVT-20-025704, Process development for biotechnological production of
fructooligosaccharides (Milan Polakovič)
The growing demand for healthy food including non-synthetic additives forms a potential for significant
enlargement of the existing production capaticies of fructooligosaccharides, which belong to important prebiotics.
The ambition of the project is to develop a technological process which could be implemented. The project
elaborates all principal steps of the production process which are: aerobic cultivation of cells Aureobasidium
pullulans, isolation and immobilization of enzyme fructosyltransferase, biocatalytic production of
fructooligosaccharides, and the adsorption separation of fructooligosaccharides.
Project duration: from 01.01.2005 to 31.12. 2007
K. Project No. 11 of the Slovak-Hungarian Bilateral Cooperation in Science, Enhancement of
the stability of lipase enzymes in ionic liquids (Milan Polakovič)
The joint project focuses on the bioprocess engineering aspects connected with the application of enzymatic
reactions in ionic liquids. The improved efficiency of biotransformations is envisaged by investigating the effect of
water activity and thermal stability on the performance of lipase in hydrolytic and esterification reactions using
ionic liquids as solvents. By screening suitable enzyme sources and reaction media, it is expected to obtain chiral
compounds of interest for the synthesis of fine chemicals and pharmaceuticals.
Project duration: from 01.01.2005 to 31.12. 2006
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