InnovationTowards <strong>the</strong> development of aHealth Innovation Strategy forSouth AfricaArticle by Glaudina LootsSouth Africa is currently at a significant set of crossroadsdue <strong>to</strong> <strong>the</strong> great need for <strong>health</strong> innovation <strong>to</strong> combat<strong>the</strong> tremendous <strong>health</strong> challenges in our diversesociety. The <strong>health</strong> needs should be addressed in such a waythat <strong>the</strong> serious inequalities of our society at large areencompassed <strong>and</strong> negated. This means that <strong>the</strong> medicationthat is developed should be appropriate, accessible <strong>and</strong>culturally acceptable <strong>to</strong> <strong>the</strong> population. This issue <strong>the</strong>n needs<strong>to</strong> take in<strong>to</strong> account various major challenges such asappropriate <strong>health</strong> medication, <strong>health</strong> infrastructure <strong>and</strong> alsoappropriate needs-oriented research. This article will give abroad <strong>and</strong> brief overview of <strong>the</strong> progress <strong>to</strong>wards <strong>the</strong>establishment of a Health Innovation Strategy for South Africafrom <strong>the</strong> perspective of <strong>the</strong> South African national governmentDepartment of Science <strong>and</strong> Technology.The meaning <strong>and</strong> need for a HealthInnovation StrategyThe continuous need for new drugs, vaccine <strong>and</strong> diagnostics<strong>and</strong> new processes in engineering <strong>and</strong> manufacturing, as wellas new approaches <strong>to</strong> <strong>health</strong> systems <strong>and</strong> services withindeveloping countries 1 is driving <strong>the</strong> need for <strong>the</strong> developmen<strong>to</strong>f <strong>health</strong> innovation strategies. Within this context <strong>the</strong>re is aneed for an overarching framework that can facilitate thisprocess – this is where an appropriate Health InnovationStrategy fits in<strong>to</strong> <strong>the</strong> picture.An area of global concern is that only 10% of <strong>the</strong> global<strong>health</strong> research <strong>and</strong> development budget is being spent on90% of <strong>the</strong> global <strong>health</strong> problems 2 . This unequal flow ofresources has since been referred <strong>to</strong> as <strong>the</strong> “10/90 gap”.Health in <strong>the</strong> developing countries is no longer <strong>the</strong> concern of<strong>the</strong> developed countries; however, <strong>the</strong>re is growing recognitioninternationally that <strong>the</strong> <strong>health</strong> of more than 80% of <strong>the</strong> worldis a matter of concern <strong>to</strong> all who inhabit this world. One of <strong>the</strong>crucial fac<strong>to</strong>rs responsible for this “10/90” gap is <strong>the</strong> lack ofintegration of <strong>health</strong> research in<strong>to</strong> national <strong>and</strong> internationalresearch systems.India, Brazil, China <strong>and</strong> South Africa are currently seen as<strong>the</strong> leading innovative developing countries. Of <strong>the</strong> four, SouthAfrica’s Health Research <strong>and</strong> Development (R&D) budgetas a percentage of public <strong>health</strong> expenditure is <strong>the</strong> lowest <strong>and</strong>falls behind that of India <strong>and</strong> Brazil. For South Africa <strong>to</strong> be onpar with <strong>the</strong> o<strong>the</strong>r three countries, a concerted effort needs <strong>to</strong>be made <strong>to</strong> increase <strong>the</strong> government R&D expenditure.It is increasingly being recognized that <strong>health</strong> research existswithin <strong>the</strong> broader context of research systems which, in turn,function within <strong>the</strong> specific socio-political <strong>and</strong> economiccontext of <strong>the</strong> relevant country 3 .Similarly, <strong>health</strong> innovation systems operate within a givencountry’s education, manufacturing, research <strong>and</strong>development system – guided, naturally, by regula<strong>to</strong>rysystems, intellectual property policies <strong>and</strong> market forces,domestically <strong>and</strong> internationally.It is within this complex context that <strong>the</strong> South Africangovernment <strong>and</strong>, in particular, <strong>the</strong> Department of Science <strong>and</strong>Technology, is engaged in establishing a national frameworkthat will enable research, development <strong>and</strong> innovation.Research, development <strong>and</strong> innovationwithin <strong>the</strong> South African contextThe National Research <strong>and</strong> Development Strategy (2002) 4(NRDS) in South Africa was adopted by Parliament as astrategy geared <strong>to</strong>wards <strong>the</strong> establishment of <strong>the</strong> necessaryenabling environment. The NRDS recognizes <strong>the</strong> complexinterplay <strong>and</strong> <strong>the</strong> synergies that can be created through coordinationbetween sec<strong>to</strong>r specific research systems <strong>and</strong> <strong>the</strong>National System of Innovation that includes <strong>the</strong> universities,<strong>the</strong> various national science councils, government <strong>and</strong> <strong>the</strong>private sec<strong>to</strong>r.The NRDS sees <strong>the</strong> Department of Science <strong>and</strong> Technology(DST) playing a strong role with regard <strong>to</strong> <strong>health</strong> research <strong>and</strong><strong>health</strong> technology in South Africa. Health-related researchshould soften <strong>the</strong> devastation caused by diseases.The NRDS recognizes that <strong>the</strong> following issues, althoughnot exhaustive, should form <strong>the</strong> core of <strong>the</strong> <strong>health</strong> researcheffort:✜ Underst<strong>and</strong>ing <strong>the</strong> <strong>social</strong> impact of disease.✜ Creating an environment <strong>and</strong> technologies <strong>to</strong> reduce <strong>the</strong>effect of poverty on <strong>the</strong> spread of disease.✜ Developing care <strong>and</strong> support strategies.✜ Underst<strong>and</strong>ing <strong>the</strong> challenges in providing access <strong>to</strong>prevention <strong>and</strong> care <strong>measures</strong>.✜ Developing innovative preventative strategies.✜ Developing novel <strong>the</strong>rapeutic regimes, including <strong>the</strong>utilization of indigenous knowledge.✜ Developing preventive <strong>and</strong> <strong>the</strong>rapeutic HIV/AIDS vaccines.076 ✜ Global Forum Update on Research for Health Volume 4
Innovation✜ Creating a viable vaccine manufacturing industry.✜ Appropriate forms of telemedicine could assist intransforming rural <strong>health</strong> care provision 4 .The role played by <strong>the</strong> Department of Science <strong>and</strong>Technology will be in conjunction with <strong>the</strong> o<strong>the</strong>r major playersin <strong>health</strong> research such as national <strong>and</strong> provincial governmentdepartments of Health, <strong>the</strong> Health Research Committee(HRC), <strong>the</strong> Medical Research Council <strong>and</strong> various institutionsthat conduct <strong>health</strong> research <strong>and</strong> develop or improve <strong>health</strong>technologies. The Science <strong>and</strong> Technology Interventions forHealth Innovation can <strong>the</strong>refore be seen as interventions thathave a long-term time frame, constituting a high risk <strong>and</strong>dependant on disruptive <strong>and</strong> innovative technologies.The priorities outlined in <strong>the</strong> NRDS also find support from<strong>the</strong> Millennium Development Goals. The Report highlights <strong>the</strong>need for research in<strong>to</strong> HIV/AIDS, tuberculosis <strong>and</strong> malaria<strong>and</strong> mentions that: “Science, technology, <strong>and</strong> innovationpolicy needs <strong>to</strong> be oriented <strong>to</strong>wards finding vaccines <strong>and</strong>cures for <strong>the</strong>se diseases, while creating new institutionalframeworks from which new research collaborationscan spring” 4 .In defining <strong>the</strong> role of DST in <strong>health</strong> innovation, two criticalissues have been considered: <strong>the</strong> first deals with <strong>the</strong> scope of<strong>the</strong> work that will be undertaken, <strong>and</strong> <strong>the</strong> second deals withcriteria defining research areas that are of critical importance<strong>to</strong> South Africa.Taking cognisance of <strong>the</strong> international trends, <strong>the</strong> SouthAfrican National Research <strong>and</strong> Development Strategy <strong>and</strong>also <strong>the</strong> <strong>health</strong> research priorities for South Africa, it isconsidered appropriate that <strong>the</strong> role of DST in <strong>health</strong> researchcan be broadly defined as <strong>the</strong> promotion of <strong>the</strong> development<strong>and</strong> exploitation of new technologies <strong>and</strong> <strong>the</strong> advancement ofbasic knowledge of biology <strong>and</strong> human behaviour. TheDST should consequently be primarily involved with scienceinterventions with regard <strong>to</strong> vaccine development, issuesof drug discovery, <strong>the</strong> development of new diagnostics,as well as <strong>the</strong> development of medical devices <strong>and</strong>treatment regimes.In order <strong>to</strong> insure that <strong>the</strong> research is sustainable <strong>and</strong> istranslated in<strong>to</strong> appropriate <strong>social</strong> <strong>and</strong> economic benefit, DSTshould actively participate along <strong>the</strong> entire length of <strong>the</strong>Innovation Chain. For South Africa, this Innovation Chainencompasses capacity development, technologydevelopment, including basic science <strong>and</strong> frontierprogrammes, biotechnology, nanotechnology <strong>and</strong> technologytransfer, including clinical trials, commercialization ofIntellectual Property <strong>and</strong> implementation through pilotprogrammes.Determining <strong>health</strong> research priorities inSouth AfricaBased on <strong>the</strong>se broad guidelines <strong>and</strong> <strong>to</strong> ensure focus on <strong>the</strong>country’s available resources, it is essential that <strong>the</strong> <strong>health</strong>research expenditure is (<strong>and</strong> remains) highly focused. Variouso<strong>the</strong>r attempts have been made <strong>to</strong> identify national <strong>health</strong>research priorities for South Africa; <strong>the</strong>se include, inter alia:✜ <strong>the</strong> <strong>health</strong> research priorities listed by <strong>the</strong> Department ofHealth in <strong>the</strong>ir Essential National Health Researchconference held in 1996;✜ <strong>the</strong> March 2006 Health Research Conference;✜ <strong>the</strong> National Research <strong>and</strong> Technology Foresight projec<strong>to</strong>f <strong>the</strong> Department of Arts, Culture, Science <strong>and</strong>Technology (1998) that identified specific research <strong>and</strong>technology priorities for <strong>the</strong> <strong>health</strong> sec<strong>to</strong>r.In <strong>the</strong> 2003 Initial Burden of Disease Estimates for SouthAfrica 2000, <strong>the</strong> South African Medical Research Councilidentified <strong>the</strong> <strong>to</strong>p 20 specific causes of premature mortality in2000 (see Table 1).Rank Cause of death %1 HIV/AIDS 39.02 Homicide/violence 7.53 Tuberculosis 5.04 Road traffic accidents 4.15 Diarrhoeal diseases 3.86 Lower respira<strong>to</strong>ry infections 3.87 Low birth weight 3.38 Stroke 2.79 Ischaemic heart disease 2.410 Protein-energy malnutrition 1.411 Suicide 1.412 Diabetes mellitus 1.213 Hypertensive heart disease 1.114 Fires 1.015 Septicaemia 1.016 Chronic obstructive pulmonary disease 0.917 Neonatal infections 0.818 Asthma 0.819 Nephritis/ nephrosis 0.820 Bacterial meningitis 0.8Table 1: Top 20 specific causes of premature mortalityBased on <strong>the</strong> priorities <strong>and</strong> information from <strong>the</strong>seexercises, certain <strong>health</strong> areas have been identified as priorityareas for <strong>the</strong> development of Department of Science <strong>and</strong>Technology interventions (see Table 2).Approach <strong>to</strong> <strong>health</strong> research, development<strong>and</strong> innovation in South AfricaThe South African Science <strong>and</strong> Technology Interventions forHealth Innovations will concentrate on <strong>the</strong> research <strong>and</strong>innovation that leads <strong>to</strong> discovery <strong>and</strong> evaluation of new drug<strong>and</strong> treatment regimes, <strong>the</strong> development of new vaccines <strong>and</strong>new robust diagnostics for <strong>the</strong> identified diseases orconditions, as well as <strong>the</strong> development of medical devices.The range of research activities will include <strong>the</strong> interrogationof indigenous knowledge, basic molecular science <strong>and</strong>genetics, chemistry <strong>and</strong> bio-chemistry, biotechnology,nanotechnology, nuclear physics, ICT, manufacturingprocesses <strong>and</strong> engineering.Consortia of researchers are encouraged <strong>to</strong> develop aspecific research strategy per intervention area. Theseconsortia will have <strong>to</strong> be representative of most of <strong>the</strong>researchers/research institutions in South Africa that aredealing with that specific disease or technology area. Theconsortia will have <strong>to</strong> appoint a manager/coordina<strong>to</strong>r. One of<strong>the</strong> universities/science councils will <strong>the</strong>n take responsibilityfor <strong>the</strong> management of <strong>the</strong> consortia <strong>and</strong> <strong>the</strong> coordina<strong>to</strong>r willbe appointed on contract basis at <strong>the</strong> specific institution.Global Forum Update on Research for Health Volume 4 ✜ 077