The Genom of Homo sapiens.pdf

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HUMAN GENOME SCANNING 329methods for validation of detected gains and losses in thesecond or even third screen will be necessary to efficientlyeliminate false-positive detection. For genomicregions that heavily cross-hybridize, it will be necessaryto develop specific arrays with unique DNA fragments tocompensate for potential false-negative detection in theseregions in the whole-genome BAC array screening.ACKNOWLEDGMENTSWe thank Qian Li for technical help in array production,Dr. Wei Yu for providing the 1p contig arrays, Dr. RueChen for the updated BAC clone position information,and Dr. Sau Wai Cheung for advice on result validation.This work was supported by a grant from the Mental RetardationResearch Center of Baylor College of Medicine.REFERENCESBeheshti B., Braude I., Marrano P., Thorner P., Zielenska M.,and Squire J.A. 2003. Chromosomal localization of DNA amplificationsin neuroblastoma tumors using cDNA microarraycomparative genomic hybridization. Neoplasia 5: 53.Brewer C., Holloway S., Zawalnyski P., Schinzel A., and Fitz-Patrick D. 1998. A chromosomal deletion map of human malformations.Am. J. Hum. Genet. 63: 1153._______ . 1999. A chromosomal duplication map of malformations:Regions of suspected haplo- and triplolethality—andtolerance of segmental aneuploidy—in humans. Am. J. Hum.Genet. 64: 1702.Cai W.W., Mao J.H., Chow C.W., Damani S., Balmain A., andBradley A. 2002. Genome-wide detection of chromosomalimbalances in tumors using BAC microarrays. Nat. Biotechnol.20: 393.Cheung V.G., Dalrymple H.L., Narasimhan S., Watts J., SchulerG., Raap A.K., Morley M., and Bruzel A. 1999. A resource ofmapped human bacterial artificial chromosome clones.Genome Res. 9: 989.Cheung V.G., Nowak N., Jang W., Kirsch I.R., Zhao S., ChenX.-N., Furey T.S., Kim U.-J., Kuo W.-L., Olivier M., ConroyJ., Kasprzyk A., Massa H., Yonescu R., Sait S., Thoreen C.,Snijders A., Lemyre E., Bailey J.A., Bruzel A., Burrill W.D.,Clegg S.M., Collins S., Dhami P., and Friedman C., et al.2001. Integration of cytogenetic landmarks into the draft sequenceof the human genome. Nature 409: 953.Dean F.B., Hosono S., Fang L., Wu X., Faruqi A.F., Bray-WardP., Sun Z., Zong Q., Du Y., Du J., Driscoll M., Song W.,Kingsmore S.F., Egholm M., and Lasken R.S. 2002. Comprehensivehuman genome amplification using multiple displacementamplification. Proc. Natl. Acad. Sci. 99: 5261.Emmert-Buck M.R., Bonner R.F., Smith P.D., Chuaqui R.F.,Zhuang Z., Goldstein S.R., Weiss R.A., and Liotta LA. 1996.Laser capture microdissection. Science 274: 998.Fare T.L., Coffey E.M., Dai H., He Y.D., Kessler D.A., KilianK.A., Koch J.E., LeProust E., Marton M.J., Meyer M.R.,Soughton R.B., Tokiwa G.Y., and Wang Y. 2003. Effects ofatmospheric ozone on microarray data quality. Anal. Chem.75: 4672.Flint J., Wilkie A.O.M., Buckle V., Winter R.M., Holland A.J.,and McDermid H.E. 1995. The detection of subtelomericchromosomal rearrangements in idiopathic mental retardation.Nat. Genet. 9: 132.Gardner R.J.M. and Sutherland G.R. 1996. Chromosome abnormalitiesand genetic counseling, 2nd edition. Oxford UniversityPress, Oxford, United Kingdom.Heiskanen M.A., Bittner M.L., Chen Y., Khan J., Adler K.E.,Trent J.M., and Meltzer P.S. 2000. Detection of gene amplificationby genomic hybridization to cDNA microarrays. CancerRes. 60: 799.Kallioniemi A., Kallioniemi O.P., Sudar D., Rutovitz D., GrayJ.W., Waldman F., and Pinkel D. 1992. Comparative genomichybridization for molecular cytogenetic analysis of solid tumors.Science 258: 818.Klein C.A., Schmidt-Kittler O., Schardt J.A., Pantel K., SpeicherM.R., and Riethmuller G. 1999. Comparative genomic hybridization,loss of heterozygosity, and DNA sequence analysisof single cells. Proc. Natl. Acad. Sci. 96: 4494.Knight S.J.L., Regan R., Nicod A., Horsley S.W., Kearney L.,Homfray T., Winter R.M., Bolton P., and Flint J. 1999. Subtlechromosomal rearrangements in children with unexplainedmental retardation. Lancet 354: 1676.Korenberg J.R., Chen X.N., Sun Z., Shi Z.Y., Ma S., Vataru E.,Yimlamai D., Weissenbach J.S., Shizuya H., Simon M.I.,Gerety S.S., Nguyen H., Zemsteva I.S., Hui L., Silva J., WuX., Birren B.W., and Hudson T.J. 1999. Human genomeanatomy: BACs integrating the genetic and cytogenetic mapsfor bridging genome and biomedicine. Genome Res. 9: 994.Lage J.M., Leamon J.H., Pejovic T., Hamann S., Lacey M., DillonD., Segraves R., Vossbrinck B., Gonzalez A., Pinkel D.,Albertson D.G., Costa J., and Lizardi P.M. 2003. Wholegenome analysis of genetic alterations in small DNA samplesusing hyperbranched strand displacement amplification andarray-CGH. Genome Res. 13: 294.Lander E.S., Linton L.M., Birren B., Nusbaum C., Zody M.C.,Baldwin J., Devon K., Dewar K., Doyle M., FitzHugh W.,Funke R., Gage D., Harris K., Heaford A., Howland J., KannL., Lehoczky J., LeVine R., McEwan P., McKernan K.,Meldrim J., Mesirov J.P., Miranda C., Morris W., and NaylorJ., et al. (International Human Genome Sequencing Consortium).2001. Initial sequencing and analysis of the humangenome. Nature 409: 860.McPherson J.D., Marra M., Hillier L., Waterston R.H., ChinwallaA., Wallis J., Sekhon M., Wylie K., Mardis E.R., WilsonR.K., Fulton R., Kucaba T.A., Wagner-McPherson C.,Barbazuk W.B., Gregory S.G., Humphray S.J., French L.,Evans R.S., Bethel G., Whittaker A., Holden J.L., McCannO.T., Dunham A., Soderlund C., and Scott C.E., et al. (InternationalHuman Genome Mapping Consortium). 2001. Aphysical map of the human genome. Nature 409: 934.Pinkel D., Segraves R., Sudar D., Clark S., Poole I., Kowbel D.,Collins C., Kuo W.L., Chen C., Zhai Y., Dairkee S.H., LjungB.M., Gray J.W., and Albertson D.G. 1998. High resolutionanalysis of DNA copy number variation using comparativegenomic hybridization to microarrays. Nat. Genet. 20: 207.Pollack J.R., Perou C.M., Alizadeh A.A., Eisen M.B., PergamenschikovA., Williams C.F., Jeffrey S.S., Botstein D., andBrown P.O. 1999. Genome-wide analysis of DNA copy-numberchanges using cDNA microarrays. Nat. Genet. 23: 41.Schena M., Shalon D., Davis R.W., and Brown P.O. 1995.Quantitative monitoring of gene expression patterns with acomplementary DNA microarray. Science 270: 467.Shapira S.K. 1998. An update on chromosome deletion and microdeletionsyndromes. Curr. Opin. Pediatr. 10: 622.Telenius H., Carter N.P., Bebb C.E., Nordenskjold M., PonderB.A., and Tunnacliffe A. 1992. Degenerate oligonucleotideprimedPCR: General amplification of target DNA by a singledegenerate primer. Genomics. 13: 718.Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., SuttonG.G., Smith H.O., Yandell M., Evans C.A., Holt R.A.,Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H.,Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H., Chen L.,Skupski M., Subramanian G., Thomas P.D., Zhang J., GaborMiklos G.L., and Nelson C., et al. 2001. The sequence of thehuman genome. Science 291: 1304.Wells D., Sherlock J.K., Handyside A.H., and Delhanty J.D.1999. Detailed chromosomal and molecular genetic analysisof single cells by whole genome amplification and comparativegenomic hybridisation. Nucleic Acids Res. 27: 1214.Zhang L., Cui X., Schmitt K., Hubert R., Navidi W., and ArnheimN. 1992. Whole genome amplification from a singlecell: Implications for genetic analysis. Proc. Natl. Acad. Sci.89: 5847.
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ForewordIn 2001, as we considered t
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The Finished Genome Sequence of Hom
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4 ROGERSFigure 2. Accumulation of h
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6 ROGERSFigure 4. Sequencing center
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8 ROGERSabcFigure 5. Ensembl view o
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10 ROGERS2000. Analysis of vertebra
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The Human Genome: Genes, Pseudogene
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VARIATION ON CHROMOSOME 7 15rived f
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VARIATION ON CHROMOSOME 7 17DNAs an
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VARIATION ON CHROMOSOME 7 19expecte
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VARIATION ON CHROMOSOME 7 21Drosoph
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Mutational Profiling in the Human G
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HUMAN MUTATIONAL PROFILING 25Anothe
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HUMAN MUTATIONAL PROFILING 27Figure
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HUMAN MUTATIONAL PROFILING 29Rieder
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32 SCHMUTZ ET AL.algorithm itself,
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34 SCHMUTZ ET AL.Figure 2. Genomic
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36 SCHMUTZ ET AL.compared. Some of
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Human Subtelomeric DNAH. RIETHMAN,
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HUMAN SUBTELOMERIC SEQUENCES 41The
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HUMAN SUBTELOMERIC SEQUENCES 43cate
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HUMAN SUBTELOMERIC SEQUENCES 45Figu
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HUMAN SUBTELOMERIC SEQUENCES 47pres
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50 COLLINSand expand the genomics r
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52 COLLINSFigure 2. A public-sector
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54 COLLINSdefine all the parts of t
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56 BENTLEYmon over many generations
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58 BENTLEYTable 1. Genetic Disease
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60 BENTLEY(Clark et al. 1998; Reich
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62 BENTLEYACKNOWLEDGMENTSThe author
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SNP Genotyping and Molecular Haplot
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GENETIC ANALYSIS OF DNA POOLS 67gen
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70 FAN ET AL.matrix is then mated t
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72 FAN ET AL.Figure 3. Views of gen
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74 FAN ET AL.including 32 duplicate
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76 FAN ET AL.Figure 7. Allele-speci
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78 FAN ET AL.microsphere-based assa
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80 BERTRANPETIT ET AL.function, may
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82 BERTRANPETIT ET AL.diversity in
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84 BERTRANPETIT ET AL.gree of block
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86 BERTRANPETIT ET AL.Figure 1. Dec
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88 BERTRANPETIT ET AL.1999. Populat
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90 WINDEMUTH ET AL.Expression data.
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92 WINDEMUTH ET AL.Table 1. A Summa
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94 WINDEMUTH ET AL.Table 2. Signifi
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96 WINDEMUTH ET AL.Table 3. Summary
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98 WINDEMUTH ET AL.Table 6. List of
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100 WINDEMUTH ET AL.Table 6. (Conti
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102 WINDEMUTH ET AL.Table 6. (Conti
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104 WINDEMUTH ET AL.much of a surpr
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106 WINDEMUTH ET AL.Given our resul
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Genetic Variation and the Control o
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GENETIC CONTROL OF TRANSCRIPTION 11
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GENETIC CONTROL OF TRANSCRIPTION 11
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Genome-wide Detection and Analysis
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RECENT SEGMENTAL DUPLICATIONS 117Fi
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RECENT SEGMENTAL DUPLICATIONS 119St
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RECENT SEGMENTAL DUPLICATIONS 121Co
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RECENT SEGMENTAL DUPLICATIONS 123Ho
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The Effects of Evolutionary Distanc
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EVOLUTIONARY DISTANCE AND GENE PRED
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EVOLUTIONARY DISTANCE AND GENE PRED
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Lineage-specific Expansion of KRAB
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EVOLUTION OF ZNF GENES 133Figure 2.
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EVOLUTION OF ZNF GENES 135Figure 4.
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EVOLUTION OF ZNF GENES 137get gene,
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EVOLUTION OF ZNF GENES 139Y., Goodw
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Sequence Organization and Functiona
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CENTROMERE ANNOTATION 143THE CENTRO
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CENTROMERE ANNOTATION 145Figure 4.
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CENTROMERE ANNOTATION 147CONCLUSION
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CENTROMERE ANNOTATION 149Schueler M
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152 PARKHILL AND THOMSONFigure 1. T
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154 PARKHILL AND THOMSONshow very h
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156 PARKHILL AND THOMSONGene Loss a
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158 PARKHILL AND THOMSONYersinia ad
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160 MCKAY ET AL.Choosing Candidate
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162 MCKAY ET AL.new comparative too
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164 MCKAY ET AL.rich. Based on a th
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166 MCKAY ET AL.Embryonic Muscle an
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168 MCKAY ET AL.native polyadenylat
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Building Comparative Maps Using 1.5
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HUMAN CHROMOSOME 1p IN THE DOG 1731
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HUMAN CHROMOSOME 1p IN THE DOG 175(
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HUMAN CHROMOSOME 1p IN THE DOG 177l
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180 GEORGES AND ANDERSSON5. There i
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182 GEORGES AND ANDERSSONplied to r
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184 GEORGES AND ANDERSSONbe common
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186 GEORGES AND ANDERSSONin humans
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Evolving Methods for the Assembly o
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ASSEMBLING LARGE GENOMES 191Figure
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ASSEMBLING LARGE GENOMES 193tant ad
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Mouse Genome Encyclopedia ProjectY.
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MOUSE GENOME ENCYCLOPEDIA PROJECT 1
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DNA Sequence Assembly and Multiple
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EULERIAN ASSEMBLY AND MULTIPLE ALIG
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Ensembl: A Genome InfrastructureE.
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ENSEMBL 215projects often submit th
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218 ZHANGthe majority of these are
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220 ZHANGFigure 2. Demonstration of
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222 ZHANG(G.X. Chen et al., in prep
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224 ZHANGWe are waiting for experim
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Ontologies for Biologists: A Commun
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ONTOLOGIES FOR BIOLOGISTS 229al. 20
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ONTOLOGIES FOR BIOLOGISTS 231TOPIC
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ONTOLOGIES FOR BIOLOGISTS 233a.b.Fi
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ONTOLOGIES FOR BIOLOGISTS 2352003.
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238 JOSHI-TOPE ET AL.Figure 1. The
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240 JOSHI-TOPE ET AL.state of knowl
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242 JOSHI-TOPE ET AL.and co-immunop
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The Share of Human Genomic DNA unde
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DNA UNDER SELECTION FROM HUMAN-MOUS
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Detecting Highly Conserved Regions
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DETECTING MULTISPECIES CONSERVED SE
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266 ROE ET AL.noncoding regions. On
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268 ROE ET AL.a48 hpf embryos in Mi
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270 ROE ET AL.aNovel gene KIAA0819[
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272 ROE ET AL.aMouseRatAP00354.2 Hu
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274 ROE ET AL.Tautz D. and Pfeifle
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276 JAILLON ET AL.Detection of Evol
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Page 291 and 292: 284 OVCHARENKO AND LOOTSdivergent r
Page 293 and 294: 286 OVCHARENKO AND LOOTSmodulation
Page 295 and 296: 288 OVCHARENKO AND LOOTSsequencing
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Page 300 and 301: Evolution of Eukaryotic Gene Repert
Page 302 and 303: EVOLUTION OF EUKARYOTIC GENES AND I
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Page 311 and 312: 304 PENNACCHIO, BAROUKH, AND RUBINA
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Page 318: High-Throughput Mouse Knockouts Pro
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Page 324 and 325: Identification of Novel Functional
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Page 342 and 343: Global Predictions and Tests of Ery
Page 344 and 345: PREDICTING GENE REGULATORY REGIONS
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Page 367 and 368: 360 MERIKANGASidentification of gen
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Page 371 and 372: 364 MERIKANGASPrevention Research G
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GENOMIC VARIATION IN MULTIGENIC TRA
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GENOMIC VARIATION IN MULTIGENIC TRA
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384 PORTEOUS ET AL.of these devasta
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386 PORTEOUS ET AL.Figure 2. The t(
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388 PORTEOUS ET AL.Figure 3. DISC1
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390 PORTEOUS ET AL.cgi-bin/hgGatewa
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392 PORTEOUS ET AL.REFERENCESAshers
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394 PORTEOUS ET AL.Valles V., Van O
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396 GOLDSTEIN, CAVALLERI, AND AHMAD
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Genetics of Quantitative Variation
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HUMAN GENE EXPRESSION VARIATION 405
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HUMAN GENE EXPRESSION VARIATION 407
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410 CHIBA-FALEK AND NUSSBAUMconcent
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412 CHIBA-FALEK AND NUSSBAUMTable 4
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414 CHIBA-FALEK AND NUSSBAUMclein i
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Genomic Perspective and CancerD. BO
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GENOMIC PERSPECTIVE AND CANCER 419F
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GENOMIC PERSPECTIVE AND CANCER 421F
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GENOMIC PERSPECTIVE AND CANCER 423f
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Chromosome 21 and Down Syndrome: Th
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DOWN SYNDROME AND HUMAN CHROMOSOME
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DOWN SYNDROME AND HUMAN CHROMOSOME
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Harvesting the Genome’s Bounty: I
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INTEGRATIVE GENOMICS 433with high-d
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INTEGRATIVE GENOMICS 435497 baits3,
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INTEGRATIVE GENOMICS 437In contrast
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INTEGRATIVE GENOMICS 439Fly19,912Ye
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INTEGRATIVE GENOMICS 441IMPLICATION
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INTEGRATIVE GENOMICS 443gene intera
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446 STANKIEWICZ ET AL.Table 1. Sele
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448 STANKIEWICZ ET AL.al. 2002; Wal
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450 STANKIEWICZ ET AL.ate DNA rearr
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452 STANKIEWICZ ET AL.Figure 5. Sch
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454 STANKIEWICZ ET AL.Legius E. 200
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456 SAKAKI ET AL.determined. We pai
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458 SAKAKI ET AL.Table 2. Base Subs
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460 SAKAKI ET AL.D.R. 2003. Genomic
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462 LIPOVICH AND KINGtions that cre
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464 LIPOVICH AND KINGto-tail antise
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466 LIPOVICH AND KINGFigure 2. Perl
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468 LIPOVICH AND KINGtions. In inte
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470 LIPOVICH AND KINGOlson M.V. and
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472 WALLACE, RUIZ-PESINI, AND MISHM
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480 CLARK ET AL.Table 1. Derivation
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482 CLARK ET AL.Table 3. Biological
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484 CLARK ET AL.be under adaptive e
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Inferring Human History: Clues from
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Y-CHROMOSOME HAPLOTYPES AND GEOGRAP
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496 OLSONTable 1. Talks Grouped by
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498 OLSONbacterial lineages prosper
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500 OLSONwill respond to perturbati
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502 OLSONIn short, much remained to
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