The Genom of Homo sapiens.pdf

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α-SYNUCLEIN EXPRESSION AND PD 415gus J., Engelender S., Ross C.A., Berger K., Schols L., SchulzJ.B., Riess O., and Kruger R. 2003. Identification and functionalcharacterization of a novel R621C mutation in the synphilin-1gene in Parkinson’s disease. Hum. Mol. Genet. 12:1223.Masliah E., Rockenstein E., Veinbergs I., Mallory M.,Hashimoto M., Takeda A., Sagara Y., Sisk A., and Mucke L.2000. Dopaminergic loss and inclusion body formation in alpha-synucleinmice: Implications for neurodegenerative disorders.Science 287: 1265.Mizuta I., Nishimura M., Mizuta E., Yamasaki S., Ohta M., andKuno S. 2002. Meta-analysis of alpha synuclein/ NACP polymorphismin Parkinson’s disease in Japan. J. Neurol. Neurosurg.Psychiatry 73: 350.Okladnova O., Syagailo Y.V., Tranitz M., Stober G., RiedererP., Mossner R., and Lesch K.P. 1998. A promoter-associatedpolymorphic repeat modulates PAX-6 expression in humanbrain. Biochem. Biophys. Res. Commun. 248: 402.Ostrerova N., Petrucelli L., Farrer M., Mehta N., Choi P., HardyJ., and Wolozin B. 1999. α-Synuclein shares physical andfunctional homology with 14-3-3 proteins. J. Neurosci. 19:5782.Parsian A., Racette B., Zhang Z.H., Chakraverty S., Rundle M.,Goate A., and Perlmutter J.S. 1998. Mutation, sequence analysis,and association studies of alpha-synuclein in Parkinson’sdisease. Neurology 51: 1757.Peters D.G., Kassam A., St. Jean P.L., Yonas H., and FerrellR.E. 1999. Functional polymorphism in the matrix metalloproteinase-9promoter as a potential risk factor for intracranialaneurysm. Stroke 30: 2612.Pollanen M.S., Dickson D.W., and Bergeron C. 1993. Pathologyand biology of the Lewy body. J. Neuropathol. Exp. Neurol.52: 183.Polymeropoulos M.H., Lavedan C., Leroy E., Ide S.E., DehejiaA., Dutra A., Pike B., Root H., Rubenstein J., Boyer R., StenroosE.S., Chandrasekharappa S., Athanassiadou A., PapapetropoulosT., Johnson W.G., Lazzarini A.M., DuvoisinR.C., Di Iorio G., Golbe L.I., and Nussbaum R.L. 1997. Mutationin the alpha-synuclein gene identified in families withParkinson’s disease. Science 276: 2045.Rideout H.J., Dietrich P., Savalle M., Dauer W.T., and StefanisL. 2003. Regulation of alpha-synuclein by bFGF in culturedventral midbrain dopaminergic neurons. J. Neurochem. 84:803.Searle S. and Blackwell J.M. 1999. Evidence for a functional repeatpolymorphism in the promoter of the human NRAMP1gene that correlates with autoimmune versus infectious diseasesusceptibility. J. Med. Genet. 36: 295.Shimajiri S., Arima N., Tanimoto A., Murata Y., Hamada T.,Wang K.Y., and Sasaguri Y. 1999. Shortened microsatellited(CA)21 sequence down-regulates promoter activity of matrixmetalloproteinase 9 gene. FEBS Lett. 455: 70.Singleton A.B., Farrer M., Johnson J., Singleton A., Hauge S.,Kachergus J., Hulihan M., Peuralinna T., Dutra A., NussbaumR., Lincoln S., Crawley A., Hanson M., Maraganore D., AdlerC., Cookson M.R., Muenter M., Baptista M., Miller D., BlancatoJ., Hardy J., and Gwinn-Hardy K. 2003. alpha-Synucleinlocus triplication causes Parkinson’s disease. Science 302:841.Spillantini M.G., Schmidt M.L., Lee V.M., Trojanowski J.Q.,Jakes R., and Goedert M. 1997. Alpha-synuclein in Lewybodies. Nature 388: 839.Stefanis L., Kholodilov N., Rideout H.J., Burke R.E., andGreene L.A. 2001. Synuclein-1 is selectively up-regulated inresponse to nerve growth factor treatment in PC12 cells. J.Neurochem. 76: 1165.Tan E.K., Matsuura T., Nagamitsu S., Khajavi M., Jankovic J.,and Ashizawa T. 2000. Polymorphism of NACP-Rep1 inParkinson’s disease: An etiologic link with essential tremor?Neurology 54: 1195.Tan E.K., Tan C., Shen H., Chai A., Lum S.Y., Teoh M.L., YihY., Wong M.C., and Zhao Y. 2003. Alpha synuclein promoterand risk of Parkinson’s disease: Microsatellite and allelic sizevariability. Neurosci. Lett. 336: 70.Tanji K., Imaizumi T., Yoshida H., Mori F., Yoshimoto M.,Satoh K., and Wakabayashi K. 2001. Expression of alphasynucleinin a human glioma cell line and its up-regulation byinterleukin-1beta. Neuroreport 12: 1909.Tanji K., Mori F., Imaizumi T., Yoshida H., Matsumiya T.,Tamo W., Yoshimoto M., Odagiri H., Sasaki M., TakahashiH., Satoh K., and Wakabayashi K. 2002. Upregulation of alpha-synucleinby lipopolysaccharide and interleukin-1 in humanmacrophages. Pathol. Int. 52: 572.Tanner C.M. and Goldman S.M. 1996. Epidemiology of Parkinson’sdisease. Neurol. Clin. 14: 317.Touchman J.W., Dehejia A., Chiba-Falek O., Cabin D.E.,Schwartz J.R., Orrison B.M., Polymeropoulos M.H., andNussbaum R.L. 2001. Human and mouse alpha-synucleingenes: Comparative genomic sequence analysis and identificationof a novel gene regulatory element. Genome Res. 11:78.Ueda K., Fukushima H., Masliah E., Xia Y., Iwai A., YoshimotoM., Otero D.A., Kondo J., Ihara Y., and Saitoh T. 1993.Molecular cloning of cDNA encoding an unrecognized componentof amyloid in Alzheimer disease. Proc. Natl. Acad.Sci. 90: 11282.Valente E.M., Bentivoglio A.R., Dixon P.H., Ferraris A., IalongoT., Frontali M., Albanese A., and Wood N.W. 2001.Localization of a novel locus for autosomal recessive earlyonsetParkinsonism, PARK6, on human chromosome 1p35-p36. Am. J. Hum. Genet. 68: 895.van Duijn C.M., Dekker M.C., Bonifati V., Galjaard R.J.,Houwing-Duistermaat J.J., Snijders P.J., Testers L., BreedveldG.J., Horstink M., Sandkuijl L.A., van Swieten J.C.,Oostra B.A., and Heutink P. 2001. Park7, a novel locus for autosomalrecessive early-onset Parkinsonism, on chromosome1p36. Am. J. Hum. Genet. 69: 629.Vila M., Vukosavic S., Jackson-Lewis V., Neystat M., JakowecM., and Przedborski S. 2000. Alpha-synuclein up-regulationin substantia nigra dopaminergic neurons following administrationof the Parkinsonian toxin MPTP. J. Neurochem. 74:721.Xia Y., Rohan de Silva H.A., Rosi B.L., Yamaoka L.H., RimmlerJ.B., Pericak-Vance M.A., Roses A.D., Chen X., MasliahE., DeTeresa R., Iwai A., Sundsmo M., Thomas R.G., HofstetterC.R., Gregory E., Hansen L.A., Katzman R., Thal L.J.,and Saitoh T. 1996. Genetic studies in Alzheimer’s diseasewith an NACP/alpha-synuclein polymorphism. Ann. Neurol.40: 207.Xu Z.P., Tsuji T., Riordan J.F., and Hu G.F. 2003. Identificationand characterization of an angiogenin-binding DNA sequencethat stimulates luciferase reporter gene expression. Biochemistry42: 121.Yamada N., Yamaya M., Okinaga S., Nakayama K., SekizawaK., Shibahara S., and Sasaki H. 2000. Microsatellite polymorphismin the heme oxygenase-1 gene promoter is associatedwith susceptibility to emphysema. Am. J. Hum. Genet.66: 187.
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ForewordIn 2001, as we considered t
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The Finished Genome Sequence of Hom
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4 ROGERSFigure 2. Accumulation of h
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6 ROGERSFigure 4. Sequencing center
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8 ROGERSabcFigure 5. Ensembl view o
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10 ROGERS2000. Analysis of vertebra
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The Human Genome: Genes, Pseudogene
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VARIATION ON CHROMOSOME 7 15rived f
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VARIATION ON CHROMOSOME 7 17DNAs an
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VARIATION ON CHROMOSOME 7 19expecte
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VARIATION ON CHROMOSOME 7 21Drosoph
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Mutational Profiling in the Human G
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HUMAN MUTATIONAL PROFILING 25Anothe
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HUMAN MUTATIONAL PROFILING 27Figure
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HUMAN MUTATIONAL PROFILING 29Rieder
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32 SCHMUTZ ET AL.algorithm itself,
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34 SCHMUTZ ET AL.Figure 2. Genomic
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36 SCHMUTZ ET AL.compared. Some of
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Human Subtelomeric DNAH. RIETHMAN,
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HUMAN SUBTELOMERIC SEQUENCES 41The
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HUMAN SUBTELOMERIC SEQUENCES 43cate
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HUMAN SUBTELOMERIC SEQUENCES 45Figu
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HUMAN SUBTELOMERIC SEQUENCES 47pres
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50 COLLINSand expand the genomics r
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52 COLLINSFigure 2. A public-sector
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54 COLLINSdefine all the parts of t
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56 BENTLEYmon over many generations
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58 BENTLEYTable 1. Genetic Disease
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60 BENTLEY(Clark et al. 1998; Reich
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62 BENTLEYACKNOWLEDGMENTSThe author
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SNP Genotyping and Molecular Haplot
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GENETIC ANALYSIS OF DNA POOLS 67gen
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70 FAN ET AL.matrix is then mated t
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72 FAN ET AL.Figure 3. Views of gen
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74 FAN ET AL.including 32 duplicate
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76 FAN ET AL.Figure 7. Allele-speci
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78 FAN ET AL.microsphere-based assa
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80 BERTRANPETIT ET AL.function, may
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82 BERTRANPETIT ET AL.diversity in
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84 BERTRANPETIT ET AL.gree of block
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86 BERTRANPETIT ET AL.Figure 1. Dec
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88 BERTRANPETIT ET AL.1999. Populat
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90 WINDEMUTH ET AL.Expression data.
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92 WINDEMUTH ET AL.Table 1. A Summa
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94 WINDEMUTH ET AL.Table 2. Signifi
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96 WINDEMUTH ET AL.Table 3. Summary
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98 WINDEMUTH ET AL.Table 6. List of
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100 WINDEMUTH ET AL.Table 6. (Conti
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102 WINDEMUTH ET AL.Table 6. (Conti
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104 WINDEMUTH ET AL.much of a surpr
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106 WINDEMUTH ET AL.Given our resul
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Genetic Variation and the Control o
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GENETIC CONTROL OF TRANSCRIPTION 11
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GENETIC CONTROL OF TRANSCRIPTION 11
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Genome-wide Detection and Analysis
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RECENT SEGMENTAL DUPLICATIONS 117Fi
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RECENT SEGMENTAL DUPLICATIONS 119St
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RECENT SEGMENTAL DUPLICATIONS 121Co
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RECENT SEGMENTAL DUPLICATIONS 123Ho
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The Effects of Evolutionary Distanc
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EVOLUTIONARY DISTANCE AND GENE PRED
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EVOLUTIONARY DISTANCE AND GENE PRED
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Lineage-specific Expansion of KRAB
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EVOLUTION OF ZNF GENES 133Figure 2.
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EVOLUTION OF ZNF GENES 135Figure 4.
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EVOLUTION OF ZNF GENES 137get gene,
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EVOLUTION OF ZNF GENES 139Y., Goodw
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Sequence Organization and Functiona
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CENTROMERE ANNOTATION 143THE CENTRO
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CENTROMERE ANNOTATION 145Figure 4.
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CENTROMERE ANNOTATION 147CONCLUSION
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CENTROMERE ANNOTATION 149Schueler M
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152 PARKHILL AND THOMSONFigure 1. T
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154 PARKHILL AND THOMSONshow very h
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156 PARKHILL AND THOMSONGene Loss a
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158 PARKHILL AND THOMSONYersinia ad
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160 MCKAY ET AL.Choosing Candidate
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162 MCKAY ET AL.new comparative too
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164 MCKAY ET AL.rich. Based on a th
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166 MCKAY ET AL.Embryonic Muscle an
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168 MCKAY ET AL.native polyadenylat
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Building Comparative Maps Using 1.5
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HUMAN CHROMOSOME 1p IN THE DOG 1731
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HUMAN CHROMOSOME 1p IN THE DOG 175(
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HUMAN CHROMOSOME 1p IN THE DOG 177l
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180 GEORGES AND ANDERSSON5. There i
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182 GEORGES AND ANDERSSONplied to r
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184 GEORGES AND ANDERSSONbe common
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186 GEORGES AND ANDERSSONin humans
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Evolving Methods for the Assembly o
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ASSEMBLING LARGE GENOMES 191Figure
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ASSEMBLING LARGE GENOMES 193tant ad
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Mouse Genome Encyclopedia ProjectY.
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MOUSE GENOME ENCYCLOPEDIA PROJECT 1
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DNA Sequence Assembly and Multiple
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EULERIAN ASSEMBLY AND MULTIPLE ALIG
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Ensembl: A Genome InfrastructureE.
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ENSEMBL 215projects often submit th
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218 ZHANGthe majority of these are
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220 ZHANGFigure 2. Demonstration of
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222 ZHANG(G.X. Chen et al., in prep
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224 ZHANGWe are waiting for experim
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Ontologies for Biologists: A Commun
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ONTOLOGIES FOR BIOLOGISTS 229al. 20
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ONTOLOGIES FOR BIOLOGISTS 231TOPIC
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ONTOLOGIES FOR BIOLOGISTS 233a.b.Fi
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ONTOLOGIES FOR BIOLOGISTS 2352003.
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238 JOSHI-TOPE ET AL.Figure 1. The
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240 JOSHI-TOPE ET AL.state of knowl
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242 JOSHI-TOPE ET AL.and co-immunop
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The Share of Human Genomic DNA unde
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DNA UNDER SELECTION FROM HUMAN-MOUS
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Detecting Highly Conserved Regions
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DETECTING MULTISPECIES CONSERVED SE
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266 ROE ET AL.noncoding regions. On
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268 ROE ET AL.a48 hpf embryos in Mi
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270 ROE ET AL.aNovel gene KIAA0819[
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272 ROE ET AL.aMouseRatAP00354.2 Hu
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274 ROE ET AL.Tautz D. and Pfeifle
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276 JAILLON ET AL.Detection of Evol
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278 JAILLON ET AL.Table 1. Distribu
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280 JAILLON ET AL.Table 3. Distribu
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282 JAILLON ET AL.ecotig is a resul
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284 OVCHARENKO AND LOOTSdivergent r
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286 OVCHARENKO AND LOOTSmodulation
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288 OVCHARENKO AND LOOTSsequencing
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290 OVCHARENKO AND LOOTSments of cl
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Evolution of Eukaryotic Gene Repert
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EVOLUTION OF EUKARYOTIC GENES AND I
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304 PENNACCHIO, BAROUKH, AND RUBINA
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306 PENNACCHIO, BAROUKH, AND RUBINh
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308 PENNACCHIO, BAROUKH, AND RUBINA
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High-Throughput Mouse Knockouts Pro
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314 FRIDDLE ET AL.screen to lines o
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Identification of Novel Functional
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100 bp ladder68G1168G1168H1168H6100
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FUNCTIONAL ELEMENTS IN HUMAN DNA 32
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High-resolution Human Genome Scanni
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HUMAN GENOME SCANNING 325false-posi
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HUMAN GENOME SCANNING 327affecting
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HUMAN GENOME SCANNING 329methods fo
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332 MALEK ET AL.Figure 1. The bacte
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334 MALEK ET AL.J., Vincent S., and
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336 HARDISON ET AL.reflect blocks o
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338 HARDISON ET AL.plain the region
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340 HARDISON ET AL.CALIBRATION OF T
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342 HARDISON ET AL.PositionRP2.3noE
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344 HARDISON ET AL.cific chromosoma
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346 WESTON ET AL.these differences
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348 WESTON ET AL.els controlled by
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350 WESTON ET AL.ures prominently i
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352 WESTON ET AL.nal and Bop, which
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354 WESTON ET AL.ablp 1466 bopbcrtB
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356 WESTON ET AL.like fold (Fig. 6)
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Implications of Genomics for Public
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GENETIC EPIDEMIOLOGY 361lytic epide
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GENETIC EPIDEMIOLOGY 363curate risk
Page 372 and 373: A Model System for Identifying Gene
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Page 378: PTC TASTE GENETICS 371the emergence
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Page 385 and 386: 378 MCCALLION ET AL.Table 3. HSCR A
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Page 390 and 391: Genetics of Schizophrenia and Bipol
Page 392 and 393: SCHIZOPHRENIA AND BIPOLAR AFFECTIVE
Page 402 and 403: The Genetics of Common Diseases: 10
Page 404 and 405: GENETICS OF COMMON DISEASES 397with
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Page 411 and 412: 404 CHEUNG ET AL.netic analysis. Ex
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Page 416 and 417: Regulation of α-Synuclein Expressi
Page 418 and 419: α-SYNUCLEIN EXPRESSION AND PD 411T
Page 420 and 421: 1. The levels of α-synuclein prote
Page 424 and 425: Genomic Perspective and CancerD. BO
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Page 430 and 431: GENOMIC PERSPECTIVE AND CANCER 423f
Page 432 and 433: Chromosome 21 and Down Syndrome: Th
Page 434 and 435: DOWN SYNDROME AND HUMAN CHROMOSOME
Page 436 and 437: DOWN SYNDROME AND HUMAN CHROMOSOME
Page 438 and 439: Harvesting the Genome’s Bounty: I
Page 440 and 441: INTEGRATIVE GENOMICS 433with high-d
Page 442 and 443: INTEGRATIVE GENOMICS 435497 baits3,
Page 444 and 445: INTEGRATIVE GENOMICS 437In contrast
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Page 448 and 449: INTEGRATIVE GENOMICS 441IMPLICATION
Page 450: INTEGRATIVE GENOMICS 443gene intera
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Page 457 and 458: 450 STANKIEWICZ ET AL.ate DNA rearr
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Page 461 and 462: 454 STANKIEWICZ ET AL.Legius E. 200
Page 463 and 464: 456 SAKAKI ET AL.determined. We pai
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466 LIPOVICH AND KINGFigure 2. Perl
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468 LIPOVICH AND KINGtions. In inte
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470 LIPOVICH AND KINGOlson M.V. and
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472 WALLACE, RUIZ-PESINI, AND MISHM
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480 CLARK ET AL.Table 1. Derivation
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482 CLARK ET AL.Table 3. Biological
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484 CLARK ET AL.be under adaptive e
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Inferring Human History: Clues from
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Y-CHROMOSOME HAPLOTYPES AND GEOGRAP
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496 OLSONTable 1. Talks Grouped by
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498 OLSONbacterial lineages prosper
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500 OLSONwill respond to perturbati
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502 OLSONIn short, much remained to
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