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Clinical Manual for Management of the HIV-Infected ... - myCME.com

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Genitals/Rectum<br />

• Inspect <strong>the</strong> genitalia and perirectal area; note lesions, warts, etc.<br />

• Culture discharges, ulcerative lesions, vesicles, and crusted lesions<br />

<strong>for</strong> herpes simplex virus, chancroid, chlamydia, and/or gonorrhea<br />

(GC), as appropriate, and send an RPR (rapid plasma reagin) or VDRL<br />

(Venereal Disease Research Laboratory) test.<br />

Female Patients<br />

•<br />

•<br />

•<br />

•<br />

•<br />

•<br />

Speculum examination–note any lesions on vaginal walls or cervix.<br />

Obtain a Papanicolaou smear. (Note: Abnormal or inconclusive<br />

Papanicolaou smears require colposcopic follow-up, because<br />

invasive cervical cancer may progress rapidly in women with <strong>HIV</strong>.<br />

See chapter Cervical Dysplasia.)<br />

Obtain endocervical swab <strong>for</strong> GC and chlamydia, and a posterior pool<br />

swab <strong>for</strong> wet mount evaluation <strong>for</strong> trichomoniasis, Candida, and<br />

bacterial vaginosis.<br />

Bimanual exam–note size <strong>of</strong> uterus and ovaries, shape, and any<br />

tenderness or pelvic pain.<br />

Rectal examination <strong>for</strong> anorectal lesions, warts, etc, and evaluation<br />

<strong>of</strong> uterine abnormalities.<br />

Anal Papanicolaou smear.*<br />

Male Patients<br />

•<br />

•<br />

•<br />

•<br />

External genitalia–note whe<strong>the</strong>r male is circumcised; note any<br />

lesions, discharge, o<strong>the</strong>r abnormalities, as above.<br />

Testicular examination <strong>for</strong> masses, tenderness.<br />

Rectal exam—digital examination to evaluate rectal tone,<br />

discharge or tenderness, masses, lesions; prostate exam if<br />

appropriate.<br />

Anal Papanicolaou smear.*<br />

* Anal Papanicolaou smear: Consider this test if follow-up<br />

evaluation <strong>of</strong> abnormal Papanicolaou test results is available.<br />

The suggested approach in <strong>HIV</strong>-infected women and men <strong>for</strong><br />

anal dysplasia screening is similar to <strong>the</strong> cervical Papanicolaou<br />

screening guidelines <strong>for</strong> women: per<strong>for</strong>m anal Papanicolaou<br />

test at initial diagnosis and, if normal, repeat at 6 months. If <strong>the</strong><br />

first 2 anal Papanicolaou smears are normal, repeat annually.<br />

If a Papanicolaou test shows ASCUS (atypical squamous cells<br />

<strong>of</strong> undetermined significance) or SIL (squamous intraepi<strong>the</strong>lial<br />

lesion), refer <strong>for</strong> anal colposcopy and biopsy. (See chapter Anal<br />

Dysplasia.)<br />

Section 1—Testing and Assessment | 1–13<br />

Extremities/ Musculoskeletal<br />

•<br />

•<br />

•<br />

•<br />

•<br />

•<br />

Joints—note any enlargement, swelling, or tenderness.<br />

Muscles—<strong>for</strong> <strong>the</strong> major muscle groups, pay close attention to<br />

muscle bulk (normal or decreased), tenderness, or weakness.<br />

Look <strong>for</strong> evidence <strong>of</strong> peripheral fat atrophy.<br />

Consider measuring baseline arm, thigh, and chest circumferences<br />

<strong>for</strong> later <strong>com</strong>parison.<br />

Note nail changes (clubbing, cyanosis, fungal infections).<br />

Assess <strong>for</strong> pedal or leg edema.<br />

Habitus<br />

• Subcutaneous fat loss (face, extremities, buttocks).<br />

• Central fat accumulation (neck, dorsocervical, breasts, abdomen).<br />

Neurologic<br />

•<br />

•<br />

•<br />

•<br />

•<br />

•<br />

Mental status—including orientation, registration, recent and<br />

remote memory, and ability to calculate (serial subtraction)<br />

Cranial nerves<br />

Peripheral sensory examination should include pinprick,<br />

temperature, and vibratory stimuli.<br />

Extremity strength and gait to discern myopathy, neuropathy, and<br />

cerebellar disease<br />

Fine motor skills such as rapid alternating movements (<strong>of</strong>ten<br />

abnormal in dementia)<br />

Deep tendon and plantar reflexes<br />

Psychiatric<br />

•<br />

•<br />

•<br />

•<br />

•<br />

Patient’s general mood (depressed, anxious, hypertalkative, etc)<br />

Verbal content–answers questions appropriately;<br />

discussion <strong>of</strong> suicide<br />

Inappropriate or unusual behavior, such as extremes <strong>of</strong> denial,<br />

hostility, or <strong>com</strong>pulsiveness<br />

See Neuropsychiatric Disorders section <strong>for</strong> more <strong>com</strong>plete<br />

in<strong>for</strong>mation on <strong>com</strong>mon pathologies.<br />

Emergency situations, such as potential suicide or violence—<br />

refer to crisis mental health services <strong>for</strong> immediate evaluation

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