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Clinical Manual for Management of the HIV-Infected ... - myCME.com

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Insomnia<br />

Background<br />

Insomnia is a <strong>com</strong>mon ac<strong>com</strong>paniment to <strong>HIV</strong><br />

infection, especially as <strong>the</strong> disease progresses and<br />

<strong>com</strong>plications worsen. Once present, insomnia tends<br />

to be chronic, unlike <strong>the</strong> transient disturbances <strong>of</strong> sleep<br />

that are a normal part <strong>of</strong> life. Most insomnia related<br />

to <strong>HIV</strong> can be characterized by <strong>the</strong> amount, quality, or<br />

timing <strong>of</strong> sleep. Insomnia may cause progressive fatigue<br />

and diminished functioning.<br />

S: Subjective<br />

The patient may <strong>com</strong>plain <strong>of</strong> <strong>the</strong> following:<br />

♦<br />

♦<br />

♦<br />

♦<br />

♦<br />

♦<br />

Difficulty initiating sleep<br />

Early-morning waking<br />

Mind-racing thoughts (eg, "I can't<br />

turn <strong>of</strong>f my thoughts.")<br />

Difficulty maintaining sleep<br />

Nonrestorative sleep (ie, although <strong>the</strong> amount <strong>of</strong><br />

sleep is adequate, <strong>the</strong> patient does not feel rested<br />

upon awakening)<br />

Nighttime restlessness<br />

Take a history to include:<br />

♦<br />

♦<br />

♦<br />

♦<br />

♦<br />

♦<br />

♦<br />

Determine <strong>the</strong> patient's bedtime sleep habits; if<br />

possible, request additional history from a sleep<br />

partner.<br />

Try to quantify how long <strong>the</strong> patient actually sleeps<br />

each night.<br />

Ask about alcohol and recreational drug use,<br />

caffeine intake, and concurrent medications that<br />

may cause insomnia as an adverse effect (eg,<br />

efavirenz, corticosteroids, pseudoephedrine, and<br />

decongestants).<br />

Screen <strong>for</strong> depression and anxiety.<br />

Ask about nightmares, life stressors, and any over<strong>the</strong>-counter<br />

medications or supplements used to<br />

promote sleep.<br />

Ask about shift work, exercise, nighttime reflux<br />

or heartburn, snoring, and periods <strong>of</strong> apnea (not<br />

breathing).<br />

Ask about collar size (size >16 or 16 1/2 is more<br />

<strong>of</strong>ten associated with sleep apnea).<br />

O: Objective<br />

Section 8—Neuropsychiatric Disorders | 8–13<br />

Per<strong>for</strong>m a general symptom-directed physical<br />

examination, including evaluation <strong>of</strong> body habitus,<br />

neurologic status, and mental status.<br />

Polysomnography may be indicated when a physiologic<br />

cause is suspected or insomnia is severe.<br />

A: Assessment<br />

A partial differential diagnosis includes <strong>the</strong> following:<br />

♦<br />

♦<br />

♦<br />

♦<br />

♦<br />

♦<br />

♦<br />

♦<br />

♦<br />

♦<br />

♦<br />

Alcohol intake (interferes with sleep 2-4 hours after<br />

ingestion)<br />

Anxiety disorder<br />

Caffeine intake<br />

Cognitive impairment<br />

Disturbance <strong>of</strong> <strong>the</strong> sleep/wake cycle because <strong>of</strong><br />

excessive time in bed<br />

Major depression (insomnia is a primary symptom)<br />

Medication adverse effects (eg, from steroids,<br />

efavirenz)<br />

O<strong>the</strong>r identifiable sleep disorders (eg, obstructive<br />

sleep apnea, periodic leg movements)<br />

Pain<br />

Recreational drug use<br />

Transient insomnia related to acute stress<br />

P: Plan<br />

Treatment<br />

The following options are available <strong>for</strong> treatment:<br />

Behavioral strategies<br />

♦<br />

To correct deleterious sleep habits, patients should<br />

do <strong>the</strong> following:<br />

♦<br />

♦<br />

♦<br />

♦<br />

♦<br />

Establish a bedtime routine.<br />

Avoid stimuli be<strong>for</strong>e bedtime.<br />

Avoid vigorous exercise within 3-4 hours <strong>of</strong><br />

bedtime.<br />

Reduce or eliminate daytime napping.<br />

Avoid eating, reading, watching TV, or working<br />

in bed.

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