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Patient Education<br />

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All patients with TB-positive sputum or<br />

bronchoscopy specimens can infect o<strong>the</strong>rs with<br />

TB. All close contacts, especially children, should<br />

be screened <strong>for</strong> TB as soon as possible and given<br />

medication to prevent (or treat) active disease.<br />

The health department will be notified <strong>of</strong> each TB<br />

case and will provide <strong>the</strong> required follow-up care.<br />

Patients must take all medicines exactly as<br />

prescribed. If doses are missed, or if <strong>the</strong> medication<br />

is stopped and restarted, <strong>the</strong> TB bacteria can develop<br />

resistance to even <strong>the</strong> best medications and be<strong>com</strong>e<br />

even more dangerous. If patients are having trouble<br />

taking <strong>the</strong> medication on schedule, <strong>the</strong>y should<br />

contact <strong>the</strong>ir health care providers immediately.<br />

If patients be<strong>com</strong>e ill, if <strong>the</strong>ir skin or eyes turn<br />

yellow, or if <strong>the</strong>ir urine darkens to a cola color, <strong>the</strong>y<br />

should see <strong>the</strong>ir health care providers immediately.<br />

Patients must keep all follow-up appointments.<br />

Blood tests will be done regularly to be sure <strong>the</strong><br />

liver is working well, and patients will be checked<br />

<strong>for</strong> medication adverse effects. They should show<br />

<strong>the</strong>ir health care providers all medications, vitamins,<br />

and supplements that <strong>the</strong>y are taking so that <strong>the</strong><br />

providers can check <strong>for</strong> drug interactions.<br />

Rifampin will make urine, sweat, and tears turn<br />

orange; this is not harmful. It will also stain plastic<br />

contact lens; patients should avoid wearing <strong>the</strong>se if<br />

<strong>the</strong>y are taking rifampin.<br />

Rifampin will cause birth control pills to fail. An<br />

alternate method <strong>of</strong> contraception should be used<br />

when <strong>the</strong> patient is under treatment.<br />

Alcohol should be avoided during treatment with<br />

TB drugs to avoid liver damage.<br />

References<br />

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Section 6—Disease-Specific Treatment | 6–73<br />

American Thoracic Society, Centers <strong>for</strong> Disease<br />

Control and Prevention, Infectious Diseases<br />

Society <strong>of</strong> America. Treatment <strong>of</strong> Tuberculosis. Am<br />

J Respir Crit Care Med. 2003 Feb 15;167(4):603-<br />

62. Available online at ajrccm.atsjournals.org/cgi/<br />

content/full/167/4/603. Accessed May 19, 2006.<br />

Blumberg HM, Leonard MK, Jasmer RM. Update<br />

on <strong>the</strong> treatment <strong>of</strong> tuberculosis and latent tuberculosis<br />

infection. JAMA. 2005 Jun 8;293(22):2776-84.<br />

Centers <strong>for</strong> Disease Control and Prevention.<br />

Acquired rifamycin resistance in persons with advanced<br />

<strong>HIV</strong> disease being treated <strong>for</strong> active tuberculosis with<br />

intermittent rifamycin-based regimens. Morb Mortal<br />

Wkly Rep. 2002 Mar 15;51(10):214-5.<br />

Centers <strong>for</strong> Disease Control and Prevention.<br />

Updated guidelines <strong>for</strong> <strong>the</strong> use <strong>of</strong> rifabutin or rifampin<br />

<strong>for</strong> <strong>the</strong> treatment and prevention <strong>of</strong> tuberculosis among<br />

<strong>HIV</strong>-infected patients taking protease inhibitors or<br />

nonnucleoside reverse transcriptase inhibitors. Morb<br />

Mortal Wkly Rep. 2000 Mar 10;49(9):185-9.<br />

Frieden T, ed. Toman’s Tuberculosis: Case Detection,<br />

Treatment and Monitoring: Questions and Answers,<br />

2nd ed. Geneva: World Health Organization; 2004.<br />

Accessed February 7, 2006.<br />

Harries A, Maher D, Graham S. TB/<strong>HIV</strong>: A<br />

<strong>Clinical</strong> <strong>Manual</strong>, 2nd ed. Geneva: World Health<br />

Organization; 2004. Accessed February 7, 2006.<br />

Iseman MD. Treatment <strong>of</strong> multidrug-resistant tuberculosis.<br />

N Engl J Med. 1993 Sep 9;329(11):784-91.<br />

Iseman MD. A Clinician's Guide to Tuberculosis.<br />

Philadelphia: Lippincott Williams & Wilkins; 2000.<br />

Reider H.L. Interventions <strong>for</strong> Tuberculosis Control<br />

and Elimination. 2002. International Union Against<br />

Tuberculosis and Lung Disease. Accessed February<br />

7, 2006.

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