Clinical Manual for Management of the HIV-Infected ... - myCME.com
Clinical Manual for Management of the HIV-Infected ... - myCME.com
Clinical Manual for Management of the HIV-Infected ... - myCME.com
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Patient Education<br />
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All patients with TB-positive sputum or<br />
bronchoscopy specimens can infect o<strong>the</strong>rs with<br />
TB. All close contacts, especially children, should<br />
be screened <strong>for</strong> TB as soon as possible and given<br />
medication to prevent (or treat) active disease.<br />
The health department will be notified <strong>of</strong> each TB<br />
case and will provide <strong>the</strong> required follow-up care.<br />
Patients must take all medicines exactly as<br />
prescribed. If doses are missed, or if <strong>the</strong> medication<br />
is stopped and restarted, <strong>the</strong> TB bacteria can develop<br />
resistance to even <strong>the</strong> best medications and be<strong>com</strong>e<br />
even more dangerous. If patients are having trouble<br />
taking <strong>the</strong> medication on schedule, <strong>the</strong>y should<br />
contact <strong>the</strong>ir health care providers immediately.<br />
If patients be<strong>com</strong>e ill, if <strong>the</strong>ir skin or eyes turn<br />
yellow, or if <strong>the</strong>ir urine darkens to a cola color, <strong>the</strong>y<br />
should see <strong>the</strong>ir health care providers immediately.<br />
Patients must keep all follow-up appointments.<br />
Blood tests will be done regularly to be sure <strong>the</strong><br />
liver is working well, and patients will be checked<br />
<strong>for</strong> medication adverse effects. They should show<br />
<strong>the</strong>ir health care providers all medications, vitamins,<br />
and supplements that <strong>the</strong>y are taking so that <strong>the</strong><br />
providers can check <strong>for</strong> drug interactions.<br />
Rifampin will make urine, sweat, and tears turn<br />
orange; this is not harmful. It will also stain plastic<br />
contact lens; patients should avoid wearing <strong>the</strong>se if<br />
<strong>the</strong>y are taking rifampin.<br />
Rifampin will cause birth control pills to fail. An<br />
alternate method <strong>of</strong> contraception should be used<br />
when <strong>the</strong> patient is under treatment.<br />
Alcohol should be avoided during treatment with<br />
TB drugs to avoid liver damage.<br />
References<br />
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Section 6—Disease-Specific Treatment | 6–73<br />
American Thoracic Society, Centers <strong>for</strong> Disease<br />
Control and Prevention, Infectious Diseases<br />
Society <strong>of</strong> America. Treatment <strong>of</strong> Tuberculosis. Am<br />
J Respir Crit Care Med. 2003 Feb 15;167(4):603-<br />
62. Available online at ajrccm.atsjournals.org/cgi/<br />
content/full/167/4/603. Accessed May 19, 2006.<br />
Blumberg HM, Leonard MK, Jasmer RM. Update<br />
on <strong>the</strong> treatment <strong>of</strong> tuberculosis and latent tuberculosis<br />
infection. JAMA. 2005 Jun 8;293(22):2776-84.<br />
Centers <strong>for</strong> Disease Control and Prevention.<br />
Acquired rifamycin resistance in persons with advanced<br />
<strong>HIV</strong> disease being treated <strong>for</strong> active tuberculosis with<br />
intermittent rifamycin-based regimens. Morb Mortal<br />
Wkly Rep. 2002 Mar 15;51(10):214-5.<br />
Centers <strong>for</strong> Disease Control and Prevention.<br />
Updated guidelines <strong>for</strong> <strong>the</strong> use <strong>of</strong> rifabutin or rifampin<br />
<strong>for</strong> <strong>the</strong> treatment and prevention <strong>of</strong> tuberculosis among<br />
<strong>HIV</strong>-infected patients taking protease inhibitors or<br />
nonnucleoside reverse transcriptase inhibitors. Morb<br />
Mortal Wkly Rep. 2000 Mar 10;49(9):185-9.<br />
Frieden T, ed. Toman’s Tuberculosis: Case Detection,<br />
Treatment and Monitoring: Questions and Answers,<br />
2nd ed. Geneva: World Health Organization; 2004.<br />
Accessed February 7, 2006.<br />
Harries A, Maher D, Graham S. TB/<strong>HIV</strong>: A<br />
<strong>Clinical</strong> <strong>Manual</strong>, 2nd ed. Geneva: World Health<br />
Organization; 2004. Accessed February 7, 2006.<br />
Iseman MD. Treatment <strong>of</strong> multidrug-resistant tuberculosis.<br />
N Engl J Med. 1993 Sep 9;329(11):784-91.<br />
Iseman MD. A Clinician's Guide to Tuberculosis.<br />
Philadelphia: Lippincott Williams & Wilkins; 2000.<br />
Reider H.L. Interventions <strong>for</strong> Tuberculosis Control<br />
and Elimination. 2002. International Union Against<br />
Tuberculosis and Lung Disease. Accessed February<br />
7, 2006.