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dysrhythmias. Ventricular fibrillation may be a causeof sudden death.0.2.6 RESPIRATORY0.2.6.1 ACUTE EXPOSUREA) Various pulmonary abnormalities have occurred includingdyspnea, asthma and pneumoconiosis.B) A chronic interstitial pulmonary change is thought tobe caused by vinyl chloride monomer; this change isdistinct from a pneumoconiosis.0.2.7 NEUROLOGIC0.2.7.1 ACUTE EXPOSUREA) VCM may cause CNS depression characterized by fatigue,headache, vertigo, ataxia, euphoria, visualdisturbances, numbness and tingling in the extremities,narcosis, loss of consciousness, and death fromrespiratory failure.0.2.8 GASTROINTESTINAL0.2.8.1 ACUTE EXPOSUREA) Nausea, vomiting, diarrhea, and severe epigastric paincan result from ingestion of the liquid.0.2.9 HEPATIC0.2.9.1 ACUTE EXPOSUREA) In chronic/subacute exposures, the target organ is theliver. Direct hepatotoxicity, hepatomegaly, and hepaticcancers, including angiosarcoma, have been reported.B) Portal hypertension can result from liver injury.0.2.10 GENITOURINARY0.2.10.1 ACUTE EXPOSUREA) Decreased libido and sperm count have occurredfollowing chronic exposures in men.0.2.13 HEMATOLOGIC0.2.13.1 ACUTE EXPOSUREA) Thrombocytopenia, porphyrinuria, and capillaryabnormalities have also been reported.0.2.14 DERMATOLOGIC0.2.14.1 ACUTE EXPOSUREA) Scleroderma, frostbite, irritation and cyanosis havebeen reported. Vinyl chloride may be absorbed throughthe skin.B) Contact dermatitis has been associated with VCM or itsplasticizers or additives.0.2.15 MUSCULOSKELETAL0.2.15.1 ACUTE EXPOSUREA) Acro-osteolysis, arthralgias, and cold extremities havebeen reported in workers exposed to VCM.0.2.20 REPRODUCTIVE HAZARDSA) Fetotoxicity and congenital malformations have been seenin animals. Human birth defects have not beensubstantiated.0.2.21 CARCINOGENICITY0.2.21.1 IARC CATEGORYA) IARC Carcinogenicity Ratings for CAS75-01-4 (IARC,2004):1) IARC Classificationa) Listed as: Vinyl chlorideb) Carcinogen Rating: 11) The agent (mixture) is carcinogenic to humans. The