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Risk of Chemicals to Man. Geneva: World Health Organization, InternationalAgency for Research on Cancer, 1972-PRESENT. (Multivolume work).V19 388(1979)]**PEER REVIEWED**40 RABBITS WERE EXPOSED FOR 4 HOURS/DAY ON 5 DAYS/WEEK FOR 12 MONTHS TOAIR CONTAINING ... (10,000 PPM) VINYL CHLORIDE. BETWEEN 9 AND 15 MONTHSEXPOSURE, 12 SKIN ACANTHOMAS AND 6 LUNG ADENOCARCINOMAS WERE SEEN. NOSIMILAR TUMORS OCCURRED IN 20 CONTROLS AFTER 15 MONTHS OBSERVATION. [IARC.Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man.Geneva: World Health Organization, International Agency for Research onCancer, 1972-PRESENT. (Multivolume work).V19 389 (1979)]**PEER REVIEWED**THE EMBRYOTOXIC & TERATOGENIC ACTION OF VINYL CHLORIDE ON 40 PREGNANTWHITE WISTAR RATS WAS EXAMINED. THE EXPT WERE CARRIED OUT UNDER THECONDITIONS OF DAILY INHALATORY POISONING DURING GESTATION AT MEAN DAILYCONCN OF 6.15 MG/CU M. THERE WAS A MANIFESTATED EMBRYOTOXIC &TERATOGENIC EFFECT OF ELEVATED TOTAL EMBRYONAL MORTALITY, LOWERED FETAL WT& INDUCTION OF EXTERNAL & INTERNAL ANOMALIES IN THE DEVELOPMENT OFTHE FETUS. THE THRESHOLD VALUE OF CONCN FOR EMBRYOTOXICITY &TERATOGENICITY WAS CALCULATED TO BE 10 MG/CU M. [MIRKOVA E ET AL; KHIGZDRAVEOPAZ 21 (5): 440 (1978)]**PEER REVIEWED**Rats and mice were exposed in an inhalation chamber to single 1 hr/concentration/ of vinyl chloride ranging from 50-50,000 ppm. A secondgroup was given 10 1 hr exposures to 500 ppm or 100 1 hr exposures to 50ppm of the same chemical. All animals were then observed for the remainderof their lives, generally 18-24 months. Moribound animals were euthanized,and survivors were sacrificed on schedule and their tissues examined forpathological changes. Specifically, the oncogenic study demonstrated doserelated effects for single 1 hr exposure of vinyl chloride monomer, athigh levels, ie 5000 and 50,000 ppm. The concn increased the incidence ofpulmonary adenomas and carcinomas in mice. Repeated exposure of A/J mice... at 500 ppm x 10 1 hr exposures also increased the incidence ofpulmonary adenomas and carcinomas. ... Rats exposed to identical concn ofvinyl chloride monomer failed to elicit a tumorigenic response. [Hehir RMet al; Environ Health Perspect 41: 63-72 (1981)]**PEER REVIEWED**Wistar rats were exposed to atmospheres containing 0 (control) or 5000 ppmvinyl chloride monomer, 7 hr/day, 5 day/wk, for 52 wk. ... 10 rats/sex pergroup were killed. ... Growth, mortality, hematology, clinical chemistry,and organ weights were studied. Slight growth retardation throughout theexperimental period and high mortality in the second half of the studywere observed in vinyl chloride monomer exposed animals. ... Bloodclotting time was ... shorter in vinyl chloride monomer exposed rats thancontrols. There were minor /incr in/ potassium content in the blood serumin vinyl chloride monomer exposed animals during the first half of thetest period. Increased blood urea nitrogen levels and relative kidneyweights were evidence that the kidneys were adversely affected by vinylchloride monomer. After 52 wk increased weights of heart and spleen, andslight signs of an anemia were noted in vinyl chloride monomer-exposedrats. ... [Feron VJ et al; Toxicol 13 (1): 25-8 (1979)]**PEER REVIEWED**Rats exposed to vinyl chloride (in air at 2500 ppm, 4-7 hr/day, 5 days/wk)from day 12 of embryonic life for 57 wk had a 63.1% incidence of liverangiosarcoma with a latency period of 49.9 wk and a 41.4% incidence oflung metastasis. The experimental tumors were similar to those of humanswith respect to gross pathology, histopathology, and metastatic behavior.