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HAD ADENOMAS AND/OR ADENOCARCINOMAS OF THE LUNG, 47% HAD MAMMARYADENOCARCINOMAS AND 16% HAD ANGIOSARCOMAS OF THE LIVER. IN 80 MALE AND 70FEMALE UNTREATED CONTROLS, 8 PULMONARY TUMORS AND 3 LYMPHOMAS WEREOBSERVED. [IARC. Monographs on the Evaluation of the Carcinogenic Risk ofChemicals to Man. Geneva: World Health Organization, International Agencyfor Research on Cancer, 1972-PRESENT. (Multivolume work).V19 384(1979)]**PEER REVIEWED**VINYL CHLORIDE WAS ADMIN FOR 7 HR/DAY ON DAYS 6-18 OF GESTATION IN MICE,RATS, & RABBITS. IT WAS CONCLUDED THAT ALTHOUGH MATERNAL TOXICITY ...OBSERVED, VINYL CHLORIDE ALONE DID NOT CAUSE SIGNIFICANT EMBRYONAL ORFETAL TOXICITY & WAS NOT TERATOGENIC IN ANY OF THE SPECIES @ CONCNTESTED. [National Research Council. Drinking Water & Health Volume 1.Washington, DC: National Academy Press, 1977.785]**PEER REVIEWED**... EXPOSURE OF SALMONELLA TYPHIMURIUM STRAINS TA1530, TA1535, & G-46... INCR NUMBER OF HIS+ REVERTANTS/PLATE 16, 12 OR 5 TIMES OVERSPONTANEOUS MUTATION RATE. MUTAGENIC RESPONSE FOR TA1530 STRAIN ... INCRWHEN S9 LIVER FRACTIONS FROM HUMANS, RATS, OR MICE ... ADDED. [NationalResearch Council. Drinking Water & Health Volume 1. Washington, DC:National Academy Press, 1977.784]**PEER REVIEWED**... INHALATION ... /OF/ VINYL CHLORIDE ... SHOWN TO PRODUCE LUNGCONGESTION & SOME HEMORRHAGING, BLOOD-CLOTTING DIFFICULTIES, &CONGESTION OF LIVER & KIDNEYS IN LAB ANIMALS. [National ResearchCouncil. Drinking Water & Health Volume 1. Washington, DC: NationalAcademy Press, 1977.784]**PEER REVIEWED**AFTER 2 HR @ 5% VINYL CHLORIDE, RATS SHOWED MODERATE INTOXICATION; 2 HR @15% PROVOKED RESP FAILURE. [National Research Council. Drinking Water& Health Volume 1. Washington, DC: National Academy Press,1977.784]**PEER REVIEWED**... DEGENERATION OF BONE & CONNECTIVE TISSUE IN MALE WISTAR RATSEXPOSED TO CONCN OF 30,000 PPM ... 4 HR/DAY ON 5 DAYS/WK FOR UP TO 12 MO.DEGENERATIVE CHANGES WERE OBSERVED IN LIVER (INTERSTITIAL HEPATITIS,NECROSIS, PROLIFERATION OF KUPFER CELLS AND FIBROSIS), KIDNEY (TUBULARNEPHROSIS & INTERSTITIAL NEPHRITIS), BRAIN (NEURONAL AND GLIAL CELLDEGENERATION). [IARC. Monographs on the Evaluation of the CarcinogenicRisk of Chemicals to Man. Geneva: World Health Organization, InternationalAgency for Research on Cancer, 1972-PRESENT. (Multivolume work).V7 302(1979)]**PEER REVIEWED**CONTINUOUS EXPOSURE OF CFY RATS TO VINYL CHLORIDE (4000 MG/CU M IN AIR)DURING PREGNANCY CAUSED INCR IN FETAL DEATHS & EMBRYOTOXIC EFFECTS.[UNGVARY G ET AL; TOXICOLOGY 11 (1): 45 (1978)]**PEER REVIEWED**DOMINANT LETHAL STUDIES OF MALE CD-1 MICE THAT HAD BEEN EXPOSED TO 3000,10,000, & 30,000 PPM FOR 5 DAYS SHOWED NO MUTAGENIC EFFECT. [ANDERSOND ET AL; ENVIRON HEALTH PERSPECT (21): 71 (1977)]**PEER REVIEWED**SPRAGUE-DAWLEY RATS WERE EXPOSED TO 10,000 PPM VINYL CHLORIDE IN AIR FOR 4HOURS/DAY ON 5 DAYS/WEEK FOR 5 WEEKS, STARTING AT THE AGE OF 13 WEEKS (120RATS PER GROUP) OR 1 DAY (43 AND 46 RATS). ANIMALS WERE OBSERVED FOR 135WEEKS. ONE HEPATOMA WAS REPORTED IN THE OLDER RATS ... IN NEWBORN RATS, 10ANGIOSARCOMAS AND 15 HEPATOMAS WERE FOUND. NO LIVER TUMORS WERE REPORTEDIN 249 CONTROLS. [IARC. Monographs on the Evaluation of the Carcinogenic
Risk of Chemicals to Man. Geneva: World Health Organization, InternationalAgency for Research on Cancer, 1972-PRESENT. (Multivolume work).V19 388(1979)]**PEER REVIEWED**40 RABBITS WERE EXPOSED FOR 4 HOURS/DAY ON 5 DAYS/WEEK FOR 12 MONTHS TOAIR CONTAINING ... (10,000 PPM) VINYL CHLORIDE. BETWEEN 9 AND 15 MONTHSEXPOSURE, 12 SKIN ACANTHOMAS AND 6 LUNG ADENOCARCINOMAS WERE SEEN. NOSIMILAR TUMORS OCCURRED IN 20 CONTROLS AFTER 15 MONTHS OBSERVATION. [IARC.Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man.Geneva: World Health Organization, International Agency for Research onCancer, 1972-PRESENT. (Multivolume work).V19 389 (1979)]**PEER REVIEWED**THE EMBRYOTOXIC & TERATOGENIC ACTION OF VINYL CHLORIDE ON 40 PREGNANTWHITE WISTAR RATS WAS EXAMINED. THE EXPT WERE CARRIED OUT UNDER THECONDITIONS OF DAILY INHALATORY POISONING DURING GESTATION AT MEAN DAILYCONCN OF 6.15 MG/CU M. THERE WAS A MANIFESTATED EMBRYOTOXIC &TERATOGENIC EFFECT OF ELEVATED TOTAL EMBRYONAL MORTALITY, LOWERED FETAL WT& INDUCTION OF EXTERNAL & INTERNAL ANOMALIES IN THE DEVELOPMENT OFTHE FETUS. THE THRESHOLD VALUE OF CONCN FOR EMBRYOTOXICITY &TERATOGENICITY WAS CALCULATED TO BE 10 MG/CU M. [MIRKOVA E ET AL; KHIGZDRAVEOPAZ 21 (5): 440 (1978)]**PEER REVIEWED**Rats and mice were exposed in an inhalation chamber to single 1 hr/concentration/ of vinyl chloride ranging from 50-50,000 ppm. A secondgroup was given 10 1 hr exposures to 500 ppm or 100 1 hr exposures to 50ppm of the same chemical. All animals were then observed for the remainderof their lives, generally 18-24 months. Moribound animals were euthanized,and survivors were sacrificed on schedule and their tissues examined forpathological changes. Specifically, the oncogenic study demonstrated doserelated effects for single 1 hr exposure of vinyl chloride monomer, athigh levels, ie 5000 and 50,000 ppm. The concn increased the incidence ofpulmonary adenomas and carcinomas in mice. Repeated exposure of A/J mice... at 500 ppm x 10 1 hr exposures also increased the incidence ofpulmonary adenomas and carcinomas. ... Rats exposed to identical concn ofvinyl chloride monomer failed to elicit a tumorigenic response. [Hehir RMet al; Environ Health Perspect 41: 63-72 (1981)]**PEER REVIEWED**Wistar rats were exposed to atmospheres containing 0 (control) or 5000 ppmvinyl chloride monomer, 7 hr/day, 5 day/wk, for 52 wk. ... 10 rats/sex pergroup were killed. ... Growth, mortality, hematology, clinical chemistry,and organ weights were studied. Slight growth retardation throughout theexperimental period and high mortality in the second half of the studywere observed in vinyl chloride monomer exposed animals. ... Bloodclotting time was ... shorter in vinyl chloride monomer exposed rats thancontrols. There were minor /incr in/ potassium content in the blood serumin vinyl chloride monomer exposed animals during the first half of thetest period. Increased blood urea nitrogen levels and relative kidneyweights were evidence that the kidneys were adversely affected by vinylchloride monomer. After 52 wk increased weights of heart and spleen, andslight signs of an anemia were noted in vinyl chloride monomer-exposedrats. ... [Feron VJ et al; Toxicol 13 (1): 25-8 (1979)]**PEER REVIEWED**Rats exposed to vinyl chloride (in air at 2500 ppm, 4-7 hr/day, 5 days/wk)from day 12 of embryonic life for 57 wk had a 63.1% incidence of liverangiosarcoma with a latency period of 49.9 wk and a 41.4% incidence oflung metastasis. The experimental tumors were similar to those of humanswith respect to gross pathology, histopathology, and metastatic behavior.
Page 1: The following information was gener
Page 5 and 6: ... ANOREXIA, ... ALLERGIC DERMATIT
Page 7 and 8: cancer. Many of the workers had bee
Page 9 and 10: personnel records of nine chemical
Page 11 and 12: worker consumed more than a very lo
Page 13 and 14: (1): 37-45 (1991)]**PEER REVIEWED**
Page 15 and 16: workers to the vinyl chloride monom
Page 17 and 18: skin cancer could bear some relatio
Page 19 and 20: N-5'-alkylpurine (AP) endonucleases
Page 21 and 22: Agency for Research on Cancer, 1979
Page 23 and 24: LIFE SUPPORT:oThis overview assumes
Page 25 and 26: exposure circumstance entails expos
Page 27: for carcinogenicity in human epidem
Page 31 and 32: exposure groups did not differ from
Page 33 and 34: in vivo. [Barbin A; IARC 150: 303-1
Page 35 and 36: developed to localize the promutage
Page 37 and 38: WORKERS. THE VALUE OBTAINED WERE IN
Page 39 and 40: (2): 259 (1977)]**PEER REVIEWED**Af
Page 41 and 42: y 1 mg/cu m of either /cmpd/ separa
Page 43 and 44: (1980) as cited in USEPA; Health an
Page 45 and 46: (1975)]**PEER REVIEWED**ENVIRONMENT
Page 47 and 48: The Koc of vinyl chloride is estima
Page 49 and 50: REVIEWED**SEDIMENT/SOIL CONCENTRATI
Page 51 and 52: Fugitive emission sources; (3) Leak
Page 53 and 54: BOILING POINT:-13.3 deg C [Lide, D.
Page 55 and 56: Washington, D.C: U.S. Government Pr
Page 57 and 58: Reactivity: 2. 2= This degree inclu
Page 59 and 60: Vinyl chloride/ decomposes on burni
Page 61 and 62: available./ ... Safety pipettes sho
Page 63 and 64: Analytical procedures ... should be
Page 65 and 66: equipment. [Association of American
Page 67 and 68: done without undue risk. Use water
Page 69 and 70: Fishbein, R. A. Griesemer, A.B. Swa
Page 71 and 72: 673-6121; Production site: Geismar,
Page 73 and 74: 91% FOR POLYVINYL CHLORIDE [Kavaler
Page 75 and 76: halogen-specific detector for the a
Page 77 and 78: phthalate esters, detectable levels
Page 79 and 80:
USEPA; Drinking water Criteria Docu
Page 81 and 82:
ADMINISTRATIVE INFORMATION:HAZARDOU
Page 83:
Field Update on 01/15/1990, 1 field
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