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th  - 1987 - 51st ENC Conference

th  - 1987 - 51st ENC Conference

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MK27<br />

QUANTITATIUN OF 1-D SPECTRA WITH LOW SIGNAL TO NOISE RATIO<br />

Sarah J. Nelson* and Truman R.,Bro~<br />

Fox Chase Cancer Center, Philadelphia, PA 1911!<br />

A new me<strong>th</strong>od of analysing 1-V spectra wi<strong>th</strong> low signal to noise ratio has<br />

been developed. In contrast to o<strong>th</strong>er techniques of noise suppression such as<br />

<strong>th</strong>e mtched filter and maximum entropy me<strong>th</strong>od, <strong>th</strong>is provides an automatic<br />

quantitation of <strong>th</strong>e spectrum. The output of <strong>th</strong>e computer algori<strong>th</strong>m which<br />

implements <strong>th</strong>e new me<strong>th</strong>od comprises estimates of (i) a slowly varying<br />

background component, (ii) <strong>th</strong>e variance of random noise, (iii) peak positions,<br />

peak heights, peak areas and (iv) <strong>th</strong>e predicted accuracy of <strong>th</strong>e peak parameter<br />

estimates. The performance of <strong>th</strong>e me<strong>th</strong>od has been investigated using a variety<br />

of simulated spectra wi<strong>th</strong> different types of background and a range of<br />

different peak heights and line wid<strong>th</strong>s. A comparison of <strong>th</strong>e filtered spectra<br />

wi<strong>th</strong> <strong>th</strong>ose obtained using <strong>th</strong>e matched filte~ and maximum entropy me<strong>th</strong>od<br />

demonstrated <strong>th</strong>e advantages of being able to directly estimate <strong>th</strong>e variable<br />

background and to use bo<strong>th</strong> peak height and peak wid<strong>th</strong> in distinguishing peaks<br />

from random noise. The me<strong>th</strong>od has also been applied to a variety of different<br />

experimental data and shows distinct advantages over <strong>th</strong>e conventional<br />

filtering techniques.

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