Acute Leukemias - Republican Scientific Medical Library

a 15.4 · Current Treatment of Newly Diagnosed L 3ALL in Adults 197
Table 15.4. Protocols of the German ALL group
B-NHL 83
Prephase
– CP 200 mg/m 2
i.v. (1 h)/d d1–d5 – PRED 3 ´20 mg/m 2
p.o./d d1–d5 Block A
– MTX 12 mg i.th.
– MTX 500 mg/m 2
i.v. (24 h) d1
– CP 200 mg/m 2
i.v./d d1–d5
– VM26 165 mg/m 2
i.v. d5
– ARAC 300 mg/m 2
i.v. d5 – PRED 60 mg/m 2
p.o. d1–d5 Block B
– MTX 12 mg i.th.
– MTX 500 mg/m 2
i.v. d1
– CP 200 mg/m 2
i.v./d d1–d5
– ADR 50 mg/m 2
i.v. d5
– PRED 60 mg/m 2
p.o./d d1–d5 B-NHL 86
Prephase
– CP 200 mg/m 2
– PRED 3 ´20 mg/m 2
Block A
– MTX, ARAC, DEXA i.th.
– VCR 2 mg i.v. d1
– MTX 1500 mg/m 2
i.v. d1 – IFO 800 mg/m 2
i.v./d d1–d5 – VM26 100 mg/m 2
i.v./d d4 and d5 – ARAC 150 mg/m 2
i.v./12 h d4 and d5
– DEXA 10 mg/m 2
p.o./d d1–d5
Block B
– MTX, ARAC, DEXA i.th.
– VCR 2 mg i.v. d1
– MTX 1500 mg/m 2
i.v. d1 – CP 200 mg/m 2
i.v./d d1–d5 – ADR 25 mg/m 2
i.v. (15 m)/d d4 and d5 – DEXA 10 mg/m 2
p.o./d d1–d5
In B-NHL 83 and 86, patients received six cycles alternating block A and B (ABABAB). In the protocol B-NHL 93, cranial irradiation was omitted, and
MTX escalated to 3 g/m 2 .