Acute Leukemias - Republican Scientific Medical Library

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Table of Contents Part I – Acute Myeloid Leukemia 1 Therapy of AML ............ E.H. Estey 1 2 Diagnosis and Classification of the Acute Myeloid Leukemias (with Discussion of the Role of the Myelodysplastic Syndromes in AML Pathogenesis) ........ D. Head, M.A. Thompson 21 3 Acute Myeloid Leukemia: Epidemiology and Etiology .... 47 B. Deschler, M. Lübbert 4 Relapsed and Refractory Acute Myeloid Leukemia .......... 57 S. Abutalib, M.S. Tallman Part II – Acute Lymphoblastic Leukemia 5 Acute Lymphoblastic Leukemia: Epidemiology and Etiology .... 77 D. Wartenberg, F. D. Groves, A. S. Adelman 6 Molecular Biology and Genetics 95 M. Wetzler, M. Kryzstof 7 Acute Lymphoblastic Leukemia: Clinical Presentation, Diagnosis, and Classification ........... 109 R.A. Larson, J. Anastasi 8 Diagnosis of Acute Lymphoblastic Leukemia ................. 119 M. Albitar, F.J. Giles, H. Kantarjian 9 General Approach to the Therapy of Adult Acute Lymphoblastic Leukemia ................. 131 S.H. Faderl, H.M. Kantarjian 10 Recent Clinical Trials in Acute Lymphoblastic Leukemia by the Cancer and Leukemia Group B . 137 R.A. Larson, D. Yu, B.L. Sanford, W. Stock 11 Conventional Therapy in Adult Acute Lymphoblastic Leukemia: Review of the LALA Program . . 145 X. Thomas, D. Fiere 12 ALL Therapy: Review of the MD Anderson Program .......... 161 S.H. Faderl, D.A. Thomas, H.M. Kantarjian 13 Treatment of Adult ALL According to Protocols of the German Multicenter Study Group for Adult ALL (GMALL) .......... 167 N. Gökbuget, R. Arnold, A. Böhme, R. Fietkau, M. Freund, A. Ganser, M. Kneba, T. Lipp, W.-D. Ludwig, G. Maschmeyer, D. Messerer, H. Rieder, E. Thiel, D. Hoelzer for the German Multicenter Study Group for Adult ALL (GMALL)
VI Table of Contents 14 Philadelphia Chromosome- Positive Acute Lymphoblastic Leukemia .................. 177 O. Sala-Torra, J.P. Radich 15 Burkitt’s Acute Lymphoblastic Leukemia (L 3ALL) in Adults .... 191 V. Ribrag, P. Casassus, P. Fenaux 16 Treatment of Lymphoblastic Lymphoma in Adults ......... 203 N. Gökbuget, D. Hoelzer 17 The Role of Allogeneic Stem Cell Transplantation in the Therapy of Adult Acute Lymphoblastic Leukemia (ALL) ............. 215 P. Kebriaei, R. Champlin 18 The Role of Autologous Stem Cell Transplantation in the Management of Acute Lymphoblastic Leukemia in Adults .......... 229 P. Kebriaei, S. Giralt 19 Novel Therapies in Acute Lymphoblastic Leukemia ...... 237 S.H. Faderl, H.M. Kantarjian 20 Minimal Residual Disease Studies in Acute Lymphoblastic Leukemia .................. 247 S. Abutalib, W. Stock 21 Central Nervous System Involvement in Adult Acute Lymphocytic Leukemia .................. 263 R.H. Alvarez, J.E. Cortes 22 Relapsed Acute Lymphoblastic Leukemia .................. 275 N. Lamanna, M. von Hassel, M. Weiss 23 Emergencies in Acute Lymphoblastic Leukemia ...... 281 O. Frankfurt, M.S. Tallman Subject Index .................. 289
Page 1 and 2: E.H. Estey · S.H. Faderl · H. M.
Page 3: E. H. Estey Department of Leukemia
Page 7 and 8: VIII Contributors S. H. Faderl Depa
Page 9 and 10: X Contributors D. Wartenberg Depart
Page 11 and 12: Therapy of AML Elihu Estey Contents
Page 13 and 14: a 1.2 · Standard Therapy 3 Table 1
Page 15 and 16: a 1.2 · Standard Therapy 5 Table 1
Page 17 and 18: a 1.2 · Standard Therapy 7 tween G
Page 19 and 20: a 1.2 · Standard Therapy 9 Fig. 1.
Page 21 and 22: a 1.2 · Standard Therapy 11 of tre
Page 23 and 24: a 1.2 · Standard Therapy 13 Table
Page 25 and 26: a 1.2 · Standard Therapy 15 permit
Page 27 and 28: a References 17 19. Care RS, Valk P
Page 29 and 30: a References 19 6-thioguanine in th
Page 31 and 32: Acute Myeloid Leukemia: Epidemiolog
Page 33 and 34: a 3.1 · Epidemiology 49 3.1.4 Gend
Page 35 and 36: a 3.2 · Etiology 51 part of the in
Page 37 and 38: a 3.2 · Etiology 53 for the develo
Page 39 and 40: a References 55 38. Crane MM, Stom
Page 41 and 42: Relapsed and Refractory Acute Myelo
Page 43 and 44: a 4.2 · Prognostic Factors in Pati
Page 45 and 46: a 4.3 · Treatment of Relapsed and
Page 47 and 48: a 4.4 · Hematopoietic Stem Cell Tr
Page 49 and 50: a 4.6 · Gemtuzumab Ozogamicin 65 T
Page 51 and 52: a 4.7 · Relapsed and Refractory Ac
Page 53 and 54: a 4.7 · Relapsed and Refractory Ac
Page 55 and 56:
a References 71 The ability of immu
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a References 73 39. Vogler WR, McCa
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a References 75 95. Sievers EL, Lar
Page 61 and 62:
Part II - Acute Lymphoblastic Leuke
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78 Chapter 5 · Acute Lymphoblastic
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Molecular Biology and Genetics Meir
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a 6.3 · Structural Aberrations 97
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a 6.3 · Structural Aberrations 99
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a 6.5 · Molecular Aberrations 101
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a References 103 clear that homozyg
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a References 105 53. Chim CS, Tam C
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a References 107 122. Lennard L, Li
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Diagnosis of Acute Lymphoblastic Le
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a 8.3 · Cytochemistry and Immunoph
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a 8.5 · Cytogenetic and Molecular
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a 8.5 · Cytogenetic and Molecular
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a References 127 including the reti
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a References 129 47. Kita K, Shirak
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Acute Lymphoblastic Leukemia: Clini
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a 7.3 · Diagnosis 111 or neoplasti
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a 7.3 · Diagnosis 113 Fig. 7.2. Hi
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a 7.3 · Diagnosis 115 The vast maj
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a References 117 dren: Biologic bas
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General Approach to the Therapy of
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a 9.3 · New Agents 133 dose methot
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a References 135 4. Gökbuget N, Ho
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138 Chapter 10 · Recent Clinical T
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146 Chapter 11 · Conventional Ther
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ALL Therapy: Review of the MD Ander
Page 145 and 146:
a 12.2 · The Hyper-CVAD Regimen in
Page 147 and 148:
a 12.3 · Subset-Specific Approache
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Treatment of Adult ALL According to
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a 13.2 · Therapy for Younger (15-6
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a 13.3 · Therapy of Ph/BCR-ABL-Pos
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a 13.5 · Prognostic Factors 173 13
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a References 175 Only patients with
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Philadelphia Chromosome-Positive Ac
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a 14.2 · Molecular Biology of the
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a 14.3 · Treatment of Ph+ ALL 181
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a 14.4 · Hematopoietic Stem Cell T
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a References 185 2. Kurzrock R, Sht
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a References 187 56. Mori T, Manabe
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a References 189 acute lymphoblasti
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192 Chapter 15 · Burkitt’s Acute
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204 Chapter 16 · Treatment of Lymp
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216 Chapter 17 · The Role of Allog
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230 Chapter 18 · The Role of Autol
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238 Chapter 19 · Novel Therapies i
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248 Chapter 20 · Minimal Residual
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264 Chapter 21 · Central Nervous S
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276 Chapter 22 · Relapsed Acute Ly
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278 Chapter 22 · Relapsed Acute Ly
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Emergencies in Acute Lymphoblastic
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a 23.5 · Hyperleukocytosis 283 LA
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a 23.9 · Neurological Complication
Page 267 and 268:
a References 287 29. Hingorani AD,
Page 269 and 270:
Subject Index A aberrant methylatio
Page 271 and 272:
a Subject Index 291 CREB, see enhan
Page 273 and 274:
a Subject Index 293 MUD, see matche
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