Acute Leukemias - Republican Scientific Medical Library

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a References 245 23. Jeha S, Gandhi V, Chan KW, et al. (2004) Clofarabine, a novel nucleoside analog, is active in pediatric patients with advanced leukemia. Blood 103(3):784–789 24. Jeha S, Razzouk BI, Rytting ME, et al. (2004) Phase II trials of clofarabine in relapsed or refractory pediatric leukemia. Blood 104:196a 25. Kantarjian HM, Gandhi V, Kozuch P, et al. (2003) Phase I clinical and pharmacology study of clofarabine in patients with solid and hematologic cancers. J Clin Oncol 21:1167–1173 26. Kantarjian H, Gandhi V, Cortes J, et al. (2003) Phase 2 clinical and pharmacologic study of clofarabine in patients with refractory or relapsed acute leukemia. Blood 102:2379–2386 27. Santini V, Kantarjian HM, Issa J-P (2001) Changes in DNA methylation in neoplasia: Pathophysiology and therapeutic implications. Ann Intern Med 134:573–586 28. Garcia-Manero G, Bueso-Ramos C, Daniel J, et al. (2002) DNA methylation patterns at relapse in adult acute lymphocytic leukemia. Clin Cancer Res 8:1897–1903 29. Garcia-Manero G, Daniel J, Smith TL, et al. (2002) DNA methylation of multiple promoter-associated CpG islands in adult acute lymphocytic leukemia. Clin Cancer Res 8:2217–2224 30. Roman-Gomez J, Jimenez-Velasco A, Castillejo JA, et al. (2004) Promoter hypermethylation of cancer-related genes: A strong independent prognostic factor in acute lymphoblastic leukemia. Blood 104:2492–2498 31. Shen L, Toyota M, Kondo Y, et al. (2003) Aberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia. Blood 101: 4131–4136 32. Faderl S, Kantarjian HM, Thomas DA, et al. (2000) Outcome of Philadelphia chromosome-positive adult acute lymphoblastic leukemia. Leuk Lymphoma 36:263–273 33. Thomas DA, Faderl S, Cortes J, et al. (2004) Treatment of Philadelphia chromosome-positive acute lymphocytic leukemia with hyper-CVAD and imatinib mesylate. Blood 103:4396–4407 34. Thomas DA, Faderl S, Cortes J, et al. (2004) Update of the Hyper- CVAD and imatinib mesylate regimen in Philadelphia (Ph) positive acute lymphocytic leukemia (ALL). Blood 104:748a 35. Towatari M, Yanada M, Usui N, et al. (2004) Combination of intensive chemotherapy and imatinib can rapidly induce high-quality complete remission for a majority of patients with newly diagnosed BCR-ABL-positive acute lymphoblastic leukemia. Blood 104:3507–3512 36. Ottmann OG, Wassmann B, Pfeifer H, et al. (2004) Imatinib given concurrently with induction chemotherapy is superior to imatinib subsequent to induction and consolidation in newly diagnosed Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL). Blood 104:197a 37. Giles F, Kantarjian H, Wassmann B, et al. (2004) A phase I/II study of AMN107, a novel aminopyrimidine inhibitor of Bcr-Abl, on a continuous daily dosing schedule in adult patients (pts) with imatinib-resistant advanced phase chronic myeloid leukemia (CML) or relapsed/refractory Philadelphia chromosome (Ph+) acute lymphoblastic leukemia (ALL). Blood 104:10a 38. Gögbuget N, Hoelzer D (2004) Treatment with monoclonal antibodies in acute lymphoblastic leukemia: Current knowledge and future prospects. Ann Hematol 83:201–205 39. Thomas DA, Cortes J, O’Brien SM, et al. (2000) Significance of CD20 positivity in de novo acute lymphocytic leukemia (ALL). Blood 96:109a 40. Thomas DA, Cortes J, Faderl S, et al. (2004) Outcome with the Hyper-CVAD and rituximab regimen in Burkitt (BL) and Burkitt-like (BLL) leukemia/lymphoma. Blood 104:901a 41. Ozsahin H, Fluss J, McLin V, et al. (2003) Rituximab with interleukin-2 after autologous bone marrow transplantation for acute lymphocytic leukemia in second remission. 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(2004) Intravenous forodesine (BCX-1777), a novel purine nucleoside phosphorylase (PNP) inhibitor, demonstrates clinical activity in patients with refractory cutaneous T-cell lymphoma. Blood 104:683a 51. Pui CH, Relling MV, Evans WE (2003) Role of pharmacogenomics and pharmacodynamics in the treatment of acute lymphoblastic leukemia. Best Pract Res Clin Haematol 15:741–756 52. Krajinovic M, Costea I, Chiasson S (2002) Polymorphism of the thymidylate synthas gene and outcome of acute lymphoblastic leukemia. Lancet 359:1033–1034 53. Ulrich CM, Yasui Y, Storb R, et al. (2001) Pharmacogenetics of methotrexate: Toxicity among marrow transplantation patients varies with the methylenetetrahydrofolate reductase C677T polymorphism. Blood 98:231–234 54. Taub JW, Matherly LH, Ravindranath Y, et al. (2002) Polymorphisms in methylenetetrahydrofolate reductase and methotrexate sensi
246 Chapter 19 · Novel Therapies in <strong>Acute</strong> Lymphoblastic Leukemia tivity in childhood acute lymphoblastic leukemia. Leukemia 16: 764–765 55. Evans WE, Crom WR, Abromowitch M, et al. (1986) Clinical pharmacodynamics of high-dose methotrexate in acute lymphocytic leukemia. Identification of a relation between concentration and effect. N Engl J Med 14:471–477 56. Relling MV, Hancock ML, Rivera GK, et al. (1999) Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyl-transferase gene locus. J Natl Cancer Inst 91:2001– 2008 57. Belkow VM, Krynetski EY, Schuetz JD, et al. (1999) Reduced folate carrier expression in acute lymphoblastic leukemia: A mechanism for ploidy but not lineage differences in methotrexate accumulation. Blood 93:1643–1650 58. Ramakers-van Woerden NL, Pieters R, Loonen AH, et al. (2000) TEL- AML1 gene fusion is related to in vitro drug sensitivity for L-asparaginase in childhood acute lymphoblastic leukemia. Blood 96:1094–1099 59. Stam RW, den Boer ML, Meijerink JP, et al. (2003) Differential mRNA expression of ara-C-metabolizing enzymes explains ara-C sensitivity in MLL gene-rearranged infant acute lymphoblastic leukemia. Blood 101:1270–1276
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E.H. Estey · S.H. Faderl · H. M.
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E. H. Estey Department of Leukemia
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VI Table of Contents 14 Philadelphi
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VIII Contributors S. H. Faderl Depa
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X Contributors D. Wartenberg Depart
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Therapy of AML Elihu Estey Contents
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a 1.2 · Standard Therapy 3 Table 1
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a 1.2 · Standard Therapy 5 Table 1
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a 1.2 · Standard Therapy 7 tween G
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a 1.2 · Standard Therapy 9 Fig. 1.
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a 1.2 · Standard Therapy 11 of tre
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a 1.2 · Standard Therapy 13 Table
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a 1.2 · Standard Therapy 15 permit
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a References 17 19. Care RS, Valk P
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a References 19 6-thioguanine in th
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Acute Myeloid Leukemia: Epidemiolog
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a 3.1 · Epidemiology 49 3.1.4 Gend
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a 3.2 · Etiology 51 part of the in
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a 3.2 · Etiology 53 for the develo
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a References 55 38. Crane MM, Stom
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Relapsed and Refractory Acute Myelo
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a 4.2 · Prognostic Factors in Pati
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a 4.3 · Treatment of Relapsed and
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a 4.4 · Hematopoietic Stem Cell Tr
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a 4.6 · Gemtuzumab Ozogamicin 65 T
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a 4.7 · Relapsed and Refractory Ac
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a 4.7 · Relapsed and Refractory Ac
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a References 71 The ability of immu
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a References 73 39. Vogler WR, McCa
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a References 75 95. Sievers EL, Lar
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Part II - Acute Lymphoblastic Leuke
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78 Chapter 5 · Acute Lymphoblastic
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Molecular Biology and Genetics Meir
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a 6.3 · Structural Aberrations 97
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a 6.3 · Structural Aberrations 99
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a 6.5 · Molecular Aberrations 101
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a References 103 clear that homozyg
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a References 105 53. Chim CS, Tam C
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a References 107 122. Lennard L, Li
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Diagnosis of Acute Lymphoblastic Le
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a 8.3 · Cytochemistry and Immunoph
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a 8.5 · Cytogenetic and Molecular
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a 8.5 · Cytogenetic and Molecular
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a References 127 including the reti
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a References 129 47. Kita K, Shirak
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Acute Lymphoblastic Leukemia: Clini
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a 7.3 · Diagnosis 111 or neoplasti
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a 7.3 · Diagnosis 113 Fig. 7.2. Hi
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a 7.3 · Diagnosis 115 The vast maj
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a References 117 dren: Biologic bas
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General Approach to the Therapy of
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a 9.3 · New Agents 133 dose methot
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a References 135 4. Gökbuget N, Ho
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138 Chapter 10 · Recent Clinical T
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146 Chapter 11 · Conventional Ther
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ALL Therapy: Review of the MD Ander
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a 12.2 · The Hyper-CVAD Regimen in
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a 12.3 · Subset-Specific Approache
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Treatment of Adult ALL According to
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a 13.2 · Therapy for Younger (15-6
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a 13.3 · Therapy of Ph/BCR-ABL-Pos
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a 13.5 · Prognostic Factors 173 13
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a References 175 Only patients with
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Philadelphia Chromosome-Positive Ac
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a 14.2 · Molecular Biology of the
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a 14.3 · Treatment of Ph+ ALL 181
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a 14.4 · Hematopoietic Stem Cell T
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a References 185 2. Kurzrock R, Sht
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a References 187 56. Mori T, Manabe
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a References 189 acute lymphoblasti
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192 Chapter 15 · Burkitt’s Acute
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Page 261 and 262: Emergencies in Acute Lymphoblastic
Page 263 and 264: a 23.5 · Hyperleukocytosis 283 LA
Page 265 and 266: a 23.9 · Neurological Complication
Page 267 and 268: a References 287 29. Hingorani AD,
Page 269 and 270: Subject Index A aberrant methylatio
Page 271 and 272: a Subject Index 291 CREB, see enhan
Page 273 and 274: a Subject Index 293 MUD, see matche
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