Acute Leukemias - Republican Scientific Medical Library

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18 Chapter 1 · Therapy of AML 49. Valk PJ, Verhaak RG, Beijen MA, et al. (2004) Prognostically useful gene-expression profiles in acute myeloid leukemia. N Engl J Med 350:1617–1628 50. Marcucci G, Radmacher MD, Ruppet AS, et al. (2005) Independent validation of prognostic relevance of a previously reported geneexpression signature in acute myeloid leukemia with normal cytogenetics: A Cancer and Leukemia Group B Study. Blood 106:755 (abstr) 51. Wheatley K, Burnett AK, Goldstone AH, et al. (1999) A simple, robust, validated and highly predictive index for the determination of risk-directed therapy in acute myeloid leukaemia derived from the MRC AML 10 trial. United Kingdom <strong>Medical</strong> Research Council’s Adult and Childhood Leukaemia Working Parties. Br J Haematol 107:69–79 52. Cassileth PA, Harrington DP, Appelbaum FR, et al. (1998) Chemotherapy compared with autologous or allogeneic bone marrow transplantation in the management of acute myeloid leukemia in first remission. 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Berman E, Little C, Gee T, et al. (1992) Reasons that patients with AML do not undergo allogeneic bone marrow transplantation. N Engl J Med 326:156–160 58. Proctor SJ, Taylor PRA, Stark A, et al. (1995) Evaluation of the impact of allogeneic transplant in first remission on an unselected population of patients with AML aged 15–55 years. Leukemia 9:1246–1251 59. Burnett AK, Goldstone AH, Stevens RM, et al. (1998) Randomized comparison of addition of autologous bone-marrow transplantation to intensive chemotherapy for acute myeloid leukaemia in first remission: Results of MRC AML 10 trial. UK <strong>Medical</strong> Research Council Adult and Children’s Leukaemia Working Parties. Lancet 351:700–708 60. Stone RM, Berg DT, George SL, et al. (1995) Granulocyte-macrophage colony-stimulating factor after initial chemotherapy for elderly patients with primary AML. N Engl J Med 332:1671–1677 61. Godwin JE, Kopecky KJ, Head DR, et al. (1998) A double blind placebo controlled trial of G-CSF in elderly patients with previously untreated AML: A Southwest Oncology Group Study 9031. Blood 91:3607–3615 62. Zittoun R, Suciu S, Mandelli F, et al. (1996) Granulocyte-macrophage colony-stimulating factor associated with induction treatment of AML: A randomized trial by the European Organization for Research and Treatment of Cancer Leukemia Cooperative Group. J Clin Oncol 14:2150–2159 63. Lowenberg B, Boogaerts MA, Daenen SMGJ, et al. (1997) The value of different modalities of GM-CSF applied during or after induction therapy of AML. J Clin Oncol 15:3496–3506 64. Lowenberg B, Suciu S, Archimbaud E, et al. (1997) Use of recombinant GM-CSF during and after remission induction chemotherapy in patients aged 61 years and older with acute myeloid leukemia: Final report of AML-21, a phase III randomised study of the EORTC-LCG and HOVON groups. Blood 90:2952–2961 65. Lowenberg B, van Putten W, Theobald M, et al. (2003) Effect of priming with granulocyte colony-stimulating factor on the outcome of chemotherapy for acute myeloid leukemia. N Engl J Med 349:743–752 66. Estey E, Smith T, Keating M, et al. (1989) Prediction of survival during induction therapy in patients with newly diagnosed AML. Leukemia 3:257–263 67. Thall P, Estey E (2001) Graphical methods for evaluating covariate effects in the Cox model. In: Crowley J (ed) Handbook of statistics in clinical oncology. Marcel Dekker, New York, pp 411–433 68. Weick J, Kopecky K, Appelbaum F, et al. (1996) A randomised investigation of high-dose versus standard-dose cytosine arabinoside with daunorubicin in patients with previously untreated acute myeloid leukemia: A Southwest Oncology Group Study. Blood 88:2841–2851 69. Bradstock KF, Matthews JP, Lowenthal RM, et al. (2005) A randomised trial of high- versus conventional-dose cytarabine in consolidation chemotherapy for adult de novo acute myeloid leukemia in first remission after induction therapy containing highdose cytarabine. Blood 105:481–488 70. Byrd JC, Dodge RK, Carroll A, et al. (1999) Patients with t(8;21)(q22; q22) and acute myeloid leukemia have superior failure-free and overall survival when repetitive cycles of high-dose cytarabine are administered. J Clin Oncol 17:3767–3775 71. Byrd JC, Ruppert AS, Mrózek K, et al. (2004) Repetitive cycles of high-dose cytarabine benefit patients with acute myeloid leukemia and inv(16)(p13q22) or t(16;16)(p13; q22): Results from CALGB 8461. J Clin Oncol 22:1087–1094 72. Rowe JM, Neuberg D, Friedenberg W, et al. (2004) A phase 3 study and of priming with GM-CSF in older adults with AML: A trial by the Eastern Cooperative Oncology Group. Blood 103:479–485 73. Anderson JE, Kopecky KJ, Willman CL, et al. (2002) Outcome after induction chemotherapy for older patients with AML is not improved with mitoxantrone and etoposide compared to daunorubicin and cytarabine: A Southwest Oncology Group Study. Blood 100:3869–3876 74. Van der Holt B, Lowenberg B, Burnett AK, et al. (2005) The value of the MDR1 reversal agent PSC-833 in addition to daunorubicin and cytarabine in the treatment of elderly patients with previously untreated AML in relation to MDR1 status at diagnosis. Blood 106:2646–2654 75. Estey EH, Thall PF, Giles FG, et al. (2002) Gemtuzumab ozogamycin with or without interleukin 11 in patients 65 years of age or older with untreated AML or high-risk MDS: Comparison with idarubicin plus high-dose continuous infusion cytosine arabinoside. Blood 99:4343–4349 76. Kahn SB, Begg CB, Mazza JJ, Bennett JM, Bonner H, Glick JH (1984) Full dose vs. attenuated daunorubicin, cytosine arabinoside and
a References 19 6-thioguanine in the treatment of acute non-lymphocytic leukemia in the elderly. J Clin Oncol 2:865–870 77. Amadori S, Suciu S, Stasi R, et al. (2005) Gemtuzumab ozogamycin as single-agent treatment for frail patients age 61 years of age and older with acute myeloid leukemia: Final results of AML-15B, a phase 2 study of the European Organization for Research and Treatment of Cancer and Gruppo Italiano Malattie Ematologiche dell’ Adulto Leukemia Groups. Leukemia 19: 1768–1773 78. National Comprehensive Cancer Network (NCCN) (2003) AML Panel. AML clinical practice guidelines. Journal of the NCCN, vol 1, 4:520–539 79. Baer MR, George SL, Dodge RK, et al. (2002) Phase 3 study of the multidrug resistance modulator PSC-833 in previously untreated patients 60 years of age and older with acute myeloid leukemia: Cancer and Leukemia Group B Study 9720. Blood 100:1224–1232 80. Sekeres MA, Stone RM, Zahrieh D, et al. (2004) Decision-making and quality of life in older adults with AML or advanced MDS. Leukemia 18:809–816 81. Estey E, Pierce S, Keating M (2000) Identification of a group of AML/MDS patients with a relatively favorable prognosis who have chromosome 5 and/or 7 abnormalities. Haematologica 85:246– 249 82. Bishop JF, Lowenthal RM, Joshua D, et al., for the Australian Leukemia Study Group (1990) Etoposide in acute nonlymphocytic leukemia. Blood 75:27–32 83. Bishop J, Matthews J, Young G, et al. (1996) A randomised trial of high-dose cytarabine in induction in acute myeloid leukemia. Blood 87:1710–1717 84. Estey E, Wang X-M, Thall P, et al. (2004) Plausibility of delaying induction therapy in untreated AML. Blood 104:879a (abstr) 85. Lowenberg B, Zittoun R, Kerkhofs H, et al. (1989) On the value of intensive remission induction therapy in elderly patients of 65 + years with AML: A randomized phase III study of the European Organization for Research and Treatment of Cancer Group. J Clin Oncol 7:1268–1274 86. Burnett AK, Milligan D, Prentice AG, et al. (2004) Low dose ara-C versus hydroxyurea with or without retinoid in older patients not considered fit for intensive chemotherapy: The UK NCRI AML14 trial. Blood 104:872a (abstr) 87. Tilly H, Castaigne S, Bordessoule D, et al. (1990) Low dose cytarabine vs. intensive chemotherapy in the treatment of acute nonlymphocytic leukemia in the elderly. J Clin Oncol 8:272–279 88. Lancet J, Gotlib J, Gojo I, et al. (2004) Tipifarnib (ZARNESTRA TM )in previously untreated poor-risk AML of the elderly: Updated results of a multicenter phase 2 trial. Blood 104:874a (abstr) 89. Stone R, DeAngelo D, Klimek V, et al. (2005) Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412. Blood 105:54–60 90. Smith D, Levis M, Beran M, et al. (2004) Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia. Blood 103:3669–3676 91. Knapper S, Burnett A, Kell J, et al. (2004) A phase II trial of the FLT3 inhibitor CEP701 as first line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy. Blood 104:864a (abstr) 92. Attar E, DeAngelo D, Ballen K, et al. (2004) Phase I dose escalating trial of bortezomib (in combination with idarubicin and cytarabine in patients with acute myeloid leukemia. Blood 104: 1799a (abstr) 93. Kantarjian H, Ravandi F, O’Brien S, et al. (2004) Decitabine lowdose schedule (100 mg/m 2 /course) in myelodysplastic syndrome. Comparison of 3 different dose schedules. Blood 104: 1437a (abstr) 94. Lubbert M, Ruter B, Schmid M, et al. (2005) Continued low-dose decitabine is an active first-line treatment of older AML patients: First results of a multicenter phase II study. Blood 106:527a (abstr) 95. Burnett A, Russell N, Kell J, Milligan D, Culligan D (2004) A phase 2 evaluation of single agent clofarabine as first line treatment for older patients with AML who are not considered fit for intensive chemotherapy. Blood 104:869a (abstr) 96. Giles F, Thomas D, Garcia-Manero G, et al. (2004) A phase I and pharmacokinetic study of VNP40101M, a novel sulfonylhydrazine alkylating agent, in patients with refractory leukemia. Clin Cancer Res 10:2908–2917 97. Marcucci G, Stock W, Dai G, et al. (2005) Phase I study of oblimersen sodium, an antisense to Bcl-2, in untreated older patients with acute myeloid leukemia: Pharmacokinetics, pharmacodynamics, and clinical activity. J Clin Oncol 23:3404–3411 98. Gerrard G, Payne E, Baker RJ, et al. (2004) Clinical effects and Pglycoprotein inhibition in patients with acute myeloid leukemia treated with zosuquidar trihydrochloride, daunorubicin and cytarabine. Haematologica 89:782–790 99. Kell W, Burnett A, Chopra R, et al. (2003) A feasibility study of simultaneous administration of gemtuzumab ozogamicin with intensive chemotherapy in induction and consolidation in younger patients with acute myeloid leukemia. Blood 102: 4277–4283 100. De Angelo D, Stone RM, Durant S, et al. (2003) Gemtuzumab ozogamicin (Mylotarg) in combination with induction chemotherapy for the treatment of patients with de novo acute myeloid leukemia: Two age-specific phase 2 trials. Blood 102:100a (abstr) 101. Kolitz J, George S, Dodge R, et al. (2004) Dose escalation studies of cytarabine, daunorubicin, and etoposide with and without multidrug resistance modulation with PSC-833 in untreated adults with acute myeloid leukemia younger than 60 years: Final induction results of cancer and leukemia group B study 9621. J Clin Oncol 22:4290–4301 102. Kolb HJ, Schattenberg A, Goldman JM, et al. (1995) Graft-versusleukemia effect of donor lymphocyte transfusions in marrow grafted patients. European Group for Blood and Marrow Transplantation Working Party Chronic Leukemia Blood 86:2041–2050 103. Molldrem JJ (2006) Vaccination for leukemia. Biol Blood Marrow Transplant 12:13–18 104. Qazilbash M, Wieder E, Rios R, et al. (2004) Vaccination with the PR1 leukemia-associated antigen can induce complete remission in patients with myeloid leukemia. Blood 104:259 (abstr) 105. Azuma T, Makita M, Ninomiya K, et al. (2002) Identification of a novel WT-1-derived peptide which induces human leukocyte antigen-A24-restricted anti-leukaemia cytotoxic T lymphocytes. Brit J Haematol 116:601–603
Page 1 and 2: E.H. Estey · S.H. Faderl · H. M.
Page 3 and 4: E. H. Estey Department of Leukemia
Page 5 and 6: VI Table of Contents 14 Philadelphi
Page 7 and 8: VIII Contributors S. H. Faderl Depa
Page 9 and 10: X Contributors D. Wartenberg Depart
Page 11 and 12: Therapy of AML Elihu Estey Contents
Page 13 and 14: a 1.2 · Standard Therapy 3 Table 1
Page 15 and 16: a 1.2 · Standard Therapy 5 Table 1
Page 17 and 18: a 1.2 · Standard Therapy 7 tween G
Page 19 and 20: a 1.2 · Standard Therapy 9 Fig. 1.
Page 21 and 22: a 1.2 · Standard Therapy 11 of tre
Page 23 and 24: a 1.2 · Standard Therapy 13 Table
Page 25 and 26: a 1.2 · Standard Therapy 15 permit
Page 27: a References 17 19. Care RS, Valk P
Page 31 and 32: Acute Myeloid Leukemia: Epidemiolog
Page 33 and 34: a 3.1 · Epidemiology 49 3.1.4 Gend
Page 35 and 36: a 3.2 · Etiology 51 part of the in
Page 37 and 38: a 3.2 · Etiology 53 for the develo
Page 39 and 40: a References 55 38. Crane MM, Stom
Page 41 and 42: Relapsed and Refractory Acute Myelo
Page 43 and 44: a 4.2 · Prognostic Factors in Pati
Page 45 and 46: a 4.3 · Treatment of Relapsed and
Page 47 and 48: a 4.4 · Hematopoietic Stem Cell Tr
Page 49 and 50: a 4.6 · Gemtuzumab Ozogamicin 65 T
Page 51 and 52: a 4.7 · Relapsed and Refractory Ac
Page 53 and 54: a 4.7 · Relapsed and Refractory Ac
Page 55 and 56: a References 71 The ability of immu
Page 57 and 58: a References 73 39. Vogler WR, McCa
Page 59 and 60: a References 75 95. Sievers EL, Lar
Page 61 and 62: Part II - Acute Lymphoblastic Leuke
Page 63 and 64: 78 Chapter 5 · Acute Lymphoblastic
Page 79 and 80:
Molecular Biology and Genetics Meir
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a 6.3 · Structural Aberrations 97
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a 6.3 · Structural Aberrations 99
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a 6.5 · Molecular Aberrations 101
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a References 103 clear that homozyg
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a References 105 53. Chim CS, Tam C
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a References 107 122. Lennard L, Li
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Diagnosis of Acute Lymphoblastic Le
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a 8.3 · Cytochemistry and Immunoph
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a 8.5 · Cytogenetic and Molecular
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a 8.5 · Cytogenetic and Molecular
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a References 127 including the reti
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a References 129 47. Kita K, Shirak
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Acute Lymphoblastic Leukemia: Clini
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a 7.3 · Diagnosis 111 or neoplasti
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a 7.3 · Diagnosis 113 Fig. 7.2. Hi
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a 7.3 · Diagnosis 115 The vast maj
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a References 117 dren: Biologic bas
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General Approach to the Therapy of
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a 9.3 · New Agents 133 dose methot
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a References 135 4. Gökbuget N, Ho
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138 Chapter 10 · Recent Clinical T
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Page 125 and 126:
Page 127 and 128:
Page 129 and 130:
146 Chapter 11 · Conventional Ther
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Page 133 and 134:
Page 135 and 136:
Page 137 and 138:
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Page 143 and 144:
ALL Therapy: Review of the MD Ander
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a 12.2 · The Hyper-CVAD Regimen in
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a 12.3 · Subset-Specific Approache
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Treatment of Adult ALL According to
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a 13.2 · Therapy for Younger (15-6
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a 13.3 · Therapy of Ph/BCR-ABL-Pos
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a 13.5 · Prognostic Factors 173 13
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a References 175 Only patients with
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Philadelphia Chromosome-Positive Ac
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a 14.2 · Molecular Biology of the
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a 14.3 · Treatment of Ph+ ALL 181
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a 14.4 · Hematopoietic Stem Cell T
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a References 185 2. Kurzrock R, Sht
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a References 187 56. Mori T, Manabe
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a References 189 acute lymphoblasti
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192 Chapter 15 · Burkitt’s Acute
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Page 185 and 186:
204 Chapter 16 · Treatment of Lymp
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216 Chapter 17 · The Role of Allog
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230 Chapter 18 · The Role of Autol
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Page 219 and 220:
238 Chapter 19 · Novel Therapies i
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248 Chapter 20 · Minimal Residual
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264 Chapter 21 · Central Nervous S
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Page 249 and 250:
Page 251 and 252:
Page 253 and 254:
Page 255 and 256:
Page 257 and 258:
276 Chapter 22 · Relapsed Acute Ly
Page 259 and 260:
278 Chapter 22 · Relapsed Acute Ly
Page 261 and 262:
Emergencies in Acute Lymphoblastic
Page 263 and 264:
a 23.5 · Hyperleukocytosis 283 LA
Page 265 and 266:
a 23.9 · Neurological Complication
Page 267 and 268:
a References 287 29. Hingorani AD,
Page 269 and 270:
Subject Index A aberrant methylatio
Page 271 and 272:
a Subject Index 291 CREB, see enhan
Page 273 and 274:
a Subject Index 293 MUD, see matche
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