Acute Leukemias - Republican Scientific Medical Library

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292 Subject Index HSCT, see hematopoietic stem cell transplantation 62 human immunodeficiency virus (HIV) 199 human leukocyte antigen (HLA) 230 hydrocortisone 193 4-hydroperoxycyclophosphamide 233 hydroxyurea 11 hyper-CVAD 162, 164, 182, 198, 270, 276 – modification 164 hypercalcemia 283 hyperdiploidy 124 hyperfractionated cyclophosphamide (HyperC) 156 hyperkalemia 282 hyperleukocytosis 283–284 hypocalcemia 282 hypodiploidy 100 I IDAC, see intermediate-dose ara-C 3 IDAC/HDAC 5–7 idarubicin 2, 66, 132, 276 IFN 153 IgH gene rearrangements 254 imatinib 134, 172, 177, 182, 184, 230, 234, 277 immunomodulation 224 immunophenotype 173, 204 immunophenotyping 113–114 immunotherapy 234 immunotoxin 140 interferon (IFN) 152 intermediate-dose ara-C (IDAC) 3 Internal tandem duplications (ITD) 4 internal tandem repeat duplications (ITD) 37 International Bone Marrow Transplantation Registry (IBMTR) 210 ionizing radiation 85 ITD, see internal tandem repeat duplications 37 ITD, see nternal tandem duplications 4 K KIT mutations 8 Klinefelter’s syndrome 83 krüeppel zinc-finger gene (BCL11A) 99 L L-asparaginase 132–133, 137, 142, 154, 267, 276, 285 lactate accumulation 283 lactate dehydrogenase (LDH) 162 lactic acidosis 283 lactic acidosis (LA) 282 LAIP, see leukemia-associated aberrant immunophenotype 41 LAIPs, see leukemia-associated immunophenotypes 15 LALA group 145 LALA study 230 LBL – salvage chemotherapy 211 – stem cell transplantation 209 LBL, see lymphoblastic lymphoma 203 LDAC, low-dose ara-C 11 Lestaurtinib 66 leucine zipper (ZIP) domain 36 leukemia 120 leukemia-associated aberrant immunophenotype (LAIP) 41 leukemia-associated immunophenotypes (LAIPs) 15 leukemic blasts 31 leukemic lymphoblasts 77 leukemic stem cell (LSC) 179 leukemogenesis 24, 38, 179 leukostasis 283–284 liposomal cytarabine 267 liposomal vincristine 134, 239 low-dose ara-C (LDAC) 11 LSC, see leukemic stem cell 179 lumbar puncture 264 lymphadenopathy 110, 112 lymphoblastic lymphoma (LBL) 143, 203 lymphoblasts 110–111, 120 – L1 precursor 120 lymphohematopoeitic cancers 87 lymphoma 120 lymphopenia 140 M mafosfamide 217, 231, 233 mantle cell lymphoma 113 matched sibling donor (MSD) 62 matched unrelated donor (MUD) 219, 231 matched-unrelated donor (MUD) 62 MD Anderson Cancer Center (MDACC) 207 MDR-AML, see myelodysplasia-related AML 24 MDS – classification 27 – diagnosis 27 MDS, see Myelodysplastic Syndromes 21, 26 mediastinal tumors, diagnostic procedures 208 mediastinal tumors (MedTu) 207 Megesterol acetate 15 meningeal leukemia 265–266 meningismus 265 mercaptopurine 270 6-mercaptopurine 133, 146, 148, 162, 234, 267 methotrexate 133, 141, 146, 148, 162, 183, 193, 207, 234, 237, 243, 267–268, 270, 278 – polyglutamates 243 methotrexate (MTX) 142 methylenetetrahydrofolate reductase (MTHFR) 243 microarray analysis 39 minimal residual disease 184 – detection 184 Minimal Residual Disease (MRD) 14, 40, 70, 116, 150, 170, 216, 247 – studies 247 mitoxantrone 7, 61, 132, 276 mixed lineage leukemia (MLL gene) 96 mixed lineage leukemia gene (MLL gene) 125 mixed lineage leukemia gene (MLL) 35 MLL gene, see mixed lineage leukemia 96 MLL, see mixed lineage leukemia gene 35 MLL-AF4 fusion gene 255 MLL-AF4 gene 97 molecular aberrations 101 molecular abnormalities 4 monoblastic leukemia 32 monoblasts 32 monoclonal antibodies (MoAb) 220 monoclonal antibody 241 – therapy 241 monoclonal antibody (MoAb) 232 – radio-immunoconjugated 232 monoclonal surface immunoglobulins (sIg) 191 monosomy 7 101, 182 MPO, see myeloperoxidase 120 MRC UKALL XII/ECOG E2993 study 219 MRD 249, 251, 257 – detection 249 – flow cytometric detection 249 – measurement 257 – monitoring 251 MRD, see minimal residual disease, analysis 174 MUD 63
a Subject Index 293 MUD, see matched-unrelated donor 62 multilineage dysplasia 25, 29 myeloblasts 111 myeloblasts, monoblasts, megakaryoblasts 22 myelodysplastic syndrome (MDS) 53 Myelodysplastic Syndromes (MDS) 21, 48 – FAB classification 26 – WHO classification 26 myeloid antigens 138 myeloid blasts 31 myeloid lineage 179 myeloperoxidase 115 myeloperoxidase (MPO) 120 myeloperoxidase (MPO) stains 29 myelosuppression 239 N NAD(P)H:quinone oxidoreductase 1 (NQO1) 52 naphthol-ASD chloroacetate esterase 30 a-naphthyl acetate (ANA) 30 a-naphthyl butyrate (ANB) 30 nelarabine 134, 143, 212, 239 neutropenia 138, 143 NHL 204 – intensive 204 – regimens 204 NHL, see Non-Hodgkin lymphoma, HIV-associated 199 N-nitroso carcinogens 88 NMSCT, see see stem cell transplantation, nonmyeloablative 221 Non-Hodgkin lymphoma (NHL) 199 non-Hodgkin’s lymphoma 221 Non-Hodgkin’s lymphomas 172 noncytotoxic agent (NCT) 11 nonimatinib 134 nonionizing radiation 85 nonspecific esterase (NSE) 120 nonspecific esterase, NSE 30 NOTCH1 point mutations 102 NPM, Nucleophosmin 38 NSE, see nonspecific esterase 120 Nucleophosmin (NPM) 38 nucleoporin 99 nucleoside analogs 239 NUMA gene 34 O oblimersen 11 oligodeoxynucleotide (ODN) 233 P P-glycoprotein 25 p-glycoprotein (P-gp) 61 papilledema 265 partially matched related donor transplant (PMRDT) 232 partially mismatched related donors (PMRD) 63 PCR, see Polymerase chain reaction 15 pegylated asparaginase 242 pentostatin 239 periodic-acid Schiff (PAS) stain 30 peripheral blood stem cells (PBSC) 222 pesticides 87 Philadelphia chromosome 124, 149, 265 Philadelphia chromosome (Ph) 177 pleural effusion 204 PML, see promyelocytic leukemia 33 PMRD, see partially mismatched related donors 63 polyethylene glycol (PEG) 141 – asparaginase 141 Polymerase chain reaction (PCR) 15, 116, 249 POMP 162 pooled analyses 86 prednisolone 101 prednisone 133, 137, 142, 146, 148, 162, 170, 233–234, 267, 270, 275 promonocytes 32 promyelocytic leukemia 15 promyelocytic leukemia (PML) 33, 66 proteinase 3 (PRTN3) 13 prothrombine gene mutation 285 Q Q-RT-PCR 41 R RA, response elements (RAREs) 34 RA, see retinoic acid 33 radionuclides 85 RAEB, refractory anemia with excess blasts 26 RAEB-t, see refractory anemia with excess blasts in transformation 2 RARa translocations 38 RARa, see retinoic acid receptor a gene 33 RAS mutations 27, 38 RAS pathway 25 rasburicase 282 receptor tyrosine kinases (RTK) 4 reduced intensity conditioning (RIC) 13, 62 reduced-intensity conditioning (RIC) 58 refractory anemia with excess blasts (RAEB) 26 refractory anemia with excess blasts in transformation (RAEB-t) 2 retinoblastoma gene 127 retinoic acid (RA) 33 retinoic acid receptor a gene (RARa) 33 retinoic acid receptor (RARa) 66 retinoic acid syndrome 68 reverse transcriptase (RT) 250 RHD, see runt homology domain 34 ribonucleoside diphosphate reductase (RNR) 243 ribonucleotide interference (RNA-I) 233 RIC, see reduced intensity conditioning 13, 62 rituximab 133, 165, 173, 198, 221, 241 RNA retroviruses 53 RT-PCR 32 RTK, see receptor tyrosine kinases 4 runt homology domain (RHD) 34 S Saccharomyces cerevisiae 282 salvage treatment 199 SCT, see stem cell transplantation 226, 229 – allogeneic 217 – nonmyeloablative 221 – psychosocial functioning 226 – quality of life 226 serum fibrinogen/fibrin degradation products (FDP) 284 SFOP programs 193 signal transduction inhibitors 241 single nucleotide polymorphism 103
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E.H. Estey · S.H. Faderl · H. M.
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E. H. Estey Department of Leukemia
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VI Table of Contents 14 Philadelphi
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VIII Contributors S. H. Faderl Depa
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X Contributors D. Wartenberg Depart
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Therapy of AML Elihu Estey Contents
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a 1.2 · Standard Therapy 3 Table 1
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a 1.2 · Standard Therapy 5 Table 1
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a 1.2 · Standard Therapy 7 tween G
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a 1.2 · Standard Therapy 9 Fig. 1.
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a 1.2 · Standard Therapy 11 of tre
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a 1.2 · Standard Therapy 13 Table
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a 1.2 · Standard Therapy 15 permit
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a References 17 19. Care RS, Valk P
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a References 19 6-thioguanine in th
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Acute Myeloid Leukemia: Epidemiolog
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a 3.1 · Epidemiology 49 3.1.4 Gend
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a 3.2 · Etiology 51 part of the in
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a 3.2 · Etiology 53 for the develo
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a References 55 38. Crane MM, Stom
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Relapsed and Refractory Acute Myelo
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a 4.2 · Prognostic Factors in Pati
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a 4.3 · Treatment of Relapsed and
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a 4.4 · Hematopoietic Stem Cell Tr
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a 4.6 · Gemtuzumab Ozogamicin 65 T
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a 4.7 · Relapsed and Refractory Ac
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a 4.7 · Relapsed and Refractory Ac
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a References 71 The ability of immu
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a References 73 39. Vogler WR, McCa
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a References 75 95. Sievers EL, Lar
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Part II - Acute Lymphoblastic Leuke
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78 Chapter 5 · Acute Lymphoblastic
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Molecular Biology and Genetics Meir
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a 6.3 · Structural Aberrations 97
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a 6.3 · Structural Aberrations 99
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a 6.5 · Molecular Aberrations 101
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a References 103 clear that homozyg
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a References 105 53. Chim CS, Tam C
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a References 107 122. Lennard L, Li
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Diagnosis of Acute Lymphoblastic Le
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a 8.3 · Cytochemistry and Immunoph
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a 8.5 · Cytogenetic and Molecular
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a 8.5 · Cytogenetic and Molecular
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a References 127 including the reti
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a References 129 47. Kita K, Shirak
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Acute Lymphoblastic Leukemia: Clini
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a 7.3 · Diagnosis 111 or neoplasti
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a 7.3 · Diagnosis 113 Fig. 7.2. Hi
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a 7.3 · Diagnosis 115 The vast maj
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a References 117 dren: Biologic bas
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General Approach to the Therapy of
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a 9.3 · New Agents 133 dose methot
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a References 135 4. Gökbuget N, Ho
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138 Chapter 10 · Recent Clinical T
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146 Chapter 11 · Conventional Ther
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ALL Therapy: Review of the MD Ander
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a 12.2 · The Hyper-CVAD Regimen in
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a 12.3 · Subset-Specific Approache
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Treatment of Adult ALL According to
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a 13.2 · Therapy for Younger (15-6
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a 13.3 · Therapy of Ph/BCR-ABL-Pos
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a 13.5 · Prognostic Factors 173 13
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a References 175 Only patients with
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Philadelphia Chromosome-Positive Ac
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a 14.2 · Molecular Biology of the
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a 14.3 · Treatment of Ph+ ALL 181
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a 14.4 · Hematopoietic Stem Cell T
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a References 185 2. Kurzrock R, Sht
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a References 187 56. Mori T, Manabe
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a References 189 acute lymphoblasti
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192 Chapter 15 · Burkitt’s Acute
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204 Chapter 16 · Treatment of Lymp
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216 Chapter 17 · The Role of Allog
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230 Chapter 18 · The Role of Autol
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238 Chapter 19 · Novel Therapies i
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Page 261 and 262: Emergencies in Acute Lymphoblastic
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Page 267 and 268: a References 287 29. Hingorani AD,
Page 269 and 270: Subject Index A aberrant methylatio
Page 271: a Subject Index 291 CREB, see enhan
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