Acute Leukemias - Republican Scientific Medical Library

206 Chapter 16 · Treatment of Lymphoblastic Lymphoma in Adults
Table 16.2. Cumulative* treatment results in adult patients with lymphoblastic lymphoma
Author N Studies N patients Age (median) CR DFs
Conventional NHL 5 114 28–45 58% 36%
(53–71%) (23–53%)
Modified NHL 5 112 14–22 92% 49%
(79–100%) (23–56%)
High grade NHL 4 64 25–34 67% 51%
(57–84%) (35–75%)
ALL Protocols 9 282 22–37 80% 56%
* according to [29]
Table 16.3. Results of ALL-type regimens in adult patients with lymphoblastic lymphoma
Author Year N pts Age
(median)
Induction CNS proph-
ylaxis
(55–100%) (45–67%)
CR rate DFS
Slater, et al. [30] 1986 20 22 MSKCC L10/17 i.th. 80% 45%
Bernasconi, et al. 1990 18
25 V,P,D,C + c/m i.th, CRT 78% 45%
[12]
13
V,P,AD,C + c/m i.th.
77% (both)
Morel, et al. [14] 1992 22 34 FRALLE i.th.
+/– CRT
91% 52%
Daenen, et al. [33] 1995 18 (T) 22 V,P,AD + c/m
+/– SCT
i.th. 100% 66%
Engelhard, et al. 1996 35
26 V,P,D,A,AC,TG,C i.th., CRT 66% 67%
[9]
18 (T)
+ c/m
72%
8 (B)
50%
Zinzani, et al. 15 1996 53 37 L17-L20 +/– SCT i.th. 55% 56%
Bouabdallah, 1998 38 30 ALL protocols i.th.,
89% 45%
et al. [16]
+/– SCT
+/– CRT
Hoelzer, et al. [11] 2002 45 25 GMALL 04/89
GMALL 05/93
i.th., CRT 93% 62%
Thomas, et al. [18] 2004 33 28 fC,V,AD,DX, HDM,
HDAC repeated
i.th. 91% 70%
Song, et al. [34] 2007 34 26 ALL-type induc- i.th. +/– n.r. 72%
tion + auto SCT TBI
c/m, consolidation/maintenance; SCT, stem cell transplantation; i.th., intrathecal; CRT, cranial irradiation; V, vincristine; P, prednisone; D, daunorubicin;
C, cyclophosphamide; AD, adriamycin; A, asparaginase; AC, cytarabine; TG, thioguanine; fC, fractionated cyclophosphamide;
DX, dexamethasone; HDM, high dose methotrexate; HDAC, high dose cytarabine; (T), T-LBL; (B), B-LBL