European Journal of Scientific Research - EuroJournals
European Journal of Scientific Research - EuroJournals
European Journal of Scientific Research - EuroJournals
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<strong>European</strong> <strong>Journal</strong> <strong>of</strong> <strong>Scientific</strong> <strong>Research</strong><br />
ISSN 1450-216X Vol.20 No.4 (2008), pp.905-913<br />
© Euro<strong>Journal</strong>s Publishing, Inc. 2008<br />
http://www.eurojournals.com/ejsr.htm<br />
Effects <strong>of</strong> Ethyl acetate Portion <strong>of</strong> Syzygium Aromaticum<br />
Flower Bud Extract on Indomethacin-Induced Gastric<br />
Ulceration and Gastric Secretion<br />
Okasha Mohammad Abdul- Halim<br />
Department <strong>of</strong> Human Physiology, Faculty <strong>of</strong> Medicine<br />
Ahmadu Bello University, Zaria, Nigeria<br />
Magaji Rabiu Abdussalam<br />
Department <strong>of</strong> Human Physiology, Faculty <strong>of</strong> Medicine<br />
Bayero University, Kano, Nigeria<br />
Abubakar Mujtaba Suleiman<br />
Department <strong>of</strong> Pharmacognosy and Drug Development, Faculty <strong>of</strong> Pharmaceutical<br />
Sciences, Ahmadu Bello University, Zaria, Nigeria<br />
Fatihu Muhammad Yakasai<br />
Department <strong>of</strong> Veterinary Pathology and Microbiology, Faculty <strong>of</strong> Veterinary Medicine<br />
Ahmadu Bello University, Zaria, Nigeria<br />
Abstract<br />
Clove, the dried flower bud <strong>of</strong> Syzygium aromaticum (Family: Myrtaceae) is one <strong>of</strong><br />
the important herbs used as indigenous medicine in India, and in Unani Medicine. It<br />
contains flavonoids and tannins among others that have bee proven to stimulate the<br />
production <strong>of</strong> prostaglandins which contribute to the maintenance <strong>of</strong> basal gastric mucosal<br />
blood flow and mucus secretion that enhance the mucosal integrity defense and repair <strong>of</strong><br />
injury. In the present work, we investigated the gastric anti-ulcerogenic and antisecretory<br />
effects <strong>of</strong> the ethyl acetate portion <strong>of</strong> the ethanolic extract <strong>of</strong> Syzygium aromaticum<br />
(SaETAC) flower bud in rats, using indomethacin as a necrotizing agent. SaETAC<br />
demonstrated a gastro-protective anti-ulcerogenic effect as well as a marked decrease <strong>of</strong><br />
volume, titritable acidity and acid output <strong>of</strong> gastric secretion in rats. The extract proved to<br />
possess some phytochemicals which may contribute to the observed gastric antiulcerogenic<br />
and anti-secretory activity.<br />
Keywords: Syzygium aromaticum, ethyl acetate, indomethacin, gastric ulcer, gastric<br />
secretion<br />
1. Introduction<br />
Clove is the dried reddish brown flower bud <strong>of</strong> Syzygium aromaticum (Family: Myrtaceae), an<br />
evergreen tropical tree 10-20 cm in height, indigenous to India, Indonesia, Zanzibar, Mauritius and Sri<br />
Lanka. Sometimes, it is called Eugenia caryophyllata. It is one <strong>of</strong> the important herbs used as