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European Journal of Scientific Research - EuroJournals

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<strong>European</strong> <strong>Journal</strong> <strong>of</strong> <strong>Scientific</strong> <strong>Research</strong><br />

ISSN 1450-216X Vol.20 No.4 (2008), pp.905-913<br />

© Euro<strong>Journal</strong>s Publishing, Inc. 2008<br />

http://www.eurojournals.com/ejsr.htm<br />

Effects <strong>of</strong> Ethyl acetate Portion <strong>of</strong> Syzygium Aromaticum<br />

Flower Bud Extract on Indomethacin-Induced Gastric<br />

Ulceration and Gastric Secretion<br />

Okasha Mohammad Abdul- Halim<br />

Department <strong>of</strong> Human Physiology, Faculty <strong>of</strong> Medicine<br />

Ahmadu Bello University, Zaria, Nigeria<br />

Magaji Rabiu Abdussalam<br />

Department <strong>of</strong> Human Physiology, Faculty <strong>of</strong> Medicine<br />

Bayero University, Kano, Nigeria<br />

Abubakar Mujtaba Suleiman<br />

Department <strong>of</strong> Pharmacognosy and Drug Development, Faculty <strong>of</strong> Pharmaceutical<br />

Sciences, Ahmadu Bello University, Zaria, Nigeria<br />

Fatihu Muhammad Yakasai<br />

Department <strong>of</strong> Veterinary Pathology and Microbiology, Faculty <strong>of</strong> Veterinary Medicine<br />

Ahmadu Bello University, Zaria, Nigeria<br />

Abstract<br />

Clove, the dried flower bud <strong>of</strong> Syzygium aromaticum (Family: Myrtaceae) is one <strong>of</strong><br />

the important herbs used as indigenous medicine in India, and in Unani Medicine. It<br />

contains flavonoids and tannins among others that have bee proven to stimulate the<br />

production <strong>of</strong> prostaglandins which contribute to the maintenance <strong>of</strong> basal gastric mucosal<br />

blood flow and mucus secretion that enhance the mucosal integrity defense and repair <strong>of</strong><br />

injury. In the present work, we investigated the gastric anti-ulcerogenic and antisecretory<br />

effects <strong>of</strong> the ethyl acetate portion <strong>of</strong> the ethanolic extract <strong>of</strong> Syzygium aromaticum<br />

(SaETAC) flower bud in rats, using indomethacin as a necrotizing agent. SaETAC<br />

demonstrated a gastro-protective anti-ulcerogenic effect as well as a marked decrease <strong>of</strong><br />

volume, titritable acidity and acid output <strong>of</strong> gastric secretion in rats. The extract proved to<br />

possess some phytochemicals which may contribute to the observed gastric antiulcerogenic<br />

and anti-secretory activity.<br />

Keywords: Syzygium aromaticum, ethyl acetate, indomethacin, gastric ulcer, gastric<br />

secretion<br />

1. Introduction<br />

Clove is the dried reddish brown flower bud <strong>of</strong> Syzygium aromaticum (Family: Myrtaceae), an<br />

evergreen tropical tree 10-20 cm in height, indigenous to India, Indonesia, Zanzibar, Mauritius and Sri<br />

Lanka. Sometimes, it is called Eugenia caryophyllata. It is one <strong>of</strong> the important herbs used as

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