Letno poročilo 2005
Letno poročilo 2005
Letno poročilo 2005
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Laboratorij za biosintezo in biotransformacijo<br />
Laboratory for Biosynthesis and Biotransformation<br />
2 objavljena znanstvena prispevka na<br />
konferencah (vabljeno predavanje)<br />
1 objavljen strokovni prispevek na konferenci<br />
(vabljeno predavanje)<br />
2 objavljena znanstvena prispevka na<br />
konferencah<br />
26 objavljenih povzetkov znanstvenih<br />
prispevkov na konferencah<br />
3 objavljeni povzetki strokovnih prispevkov<br />
na konferencah<br />
5 patentnih prijav<br />
3 patenti<br />
1 predavanje na tuji univerzi<br />
1 prispevek na konferenci brez natisa<br />
4 diplome<br />
2 doktorata<br />
DOSE@KI V LETU <strong>2005</strong><br />
- Oblikovali smo nov pristop biosinteze rekombinantnih<br />
proteinov v bakteriji E. coli, ki<br />
poteka pod posebnimi pogoji in vodi do<br />
tvorbe zanimivih proteinskih agregatov z<br />
visokim dele`em pravilno zvitega tar~nega<br />
proteina oziroma njegovega prekurzorja. V<br />
nasprotju z obi~ajnimi »klasi~nimi« inklu-<br />
SLIKA 2:<br />
Model trodimenzionalne strukture kloniranega<br />
citokroma P450 iz nitaste glive Cochlobolus lunatus<br />
(D) v primerjavi s poznano strukturo ~love{kega<br />
citokroma P450 3A4 (L).<br />
132<br />
BIBLIOGRAPHY<br />
10 Original Scientific Articles<br />
1 Review Article<br />
4 Interviews<br />
2 Published Scientific Conference Contributions<br />
(Invited Lecture)<br />
1 Published Professional Conference<br />
Contribution (Invited Lecture)<br />
2 Published Scientific Conference Contributions<br />
26 Published Scientific Conference Contribution<br />
Abstracts<br />
3 Published Professional Conference<br />
Contribution Abstracts<br />
5 Patent Applications<br />
3 Patents<br />
1 Invited Lecture at a Foreign University<br />
1 Unpublished Conference Contribution<br />
4 Undergraduate Theses<br />
2 Doctoral Dissertations<br />
IMPORTANT ACHIEVEMENTS IN <strong>2005</strong><br />
- A new approach to recombinant protein production<br />
in E. coli was developed. Biosynthesis<br />
of recombinant proteins at low tempera-<br />
FIGURE 2:<br />
Model of 3D-structure of cytochrome P450 cloned<br />
from the filamentous fungus Cochliobolus lunatus<br />
(R) in comparison to the known structure of human<br />
cytochrome P450 3A4 (L).
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