Letno poročilo 2005

Program dela NMR centra za leto 2005 je
obravnaval in potrdil Programski svet NMR centra.
V letu 2005 je delo NMR centra potekalo v
okviru 61 programov in projektov. Raziskave v
okviru NMR centra so v letu 2005 izvajali
raziskovalci naslednjih doma~ih institucij, ki so
soustanoviteljice in sovlagateljice v nakup
instrumentov NMR centra: Kemijski in{titut (KI);
Institut Jo`ef Stefan; Fakulteta za farmacijo,
Univerza v Ljubljani; Fakulteta za kemijo in
kemijsko tehnologijo, Univerza v Ljubljani in
Kmetijski in{titut Slovenije. V zadnjih nekaj letih
smo sodelovanje NMR centra na KI raz{irili na
uporabnike Narodne in univerzitetne knji`nice,
In{tituta za hmeljarstvo in pivovarstvo Slovenije,
Naravoslovno-tehni~ne, Biotehni{ke in Medicinske
fakultete Univerze v Ljubljani ter
Politehnike iz Nove Gorice. Instrumenti so na
razpolago vsem ustanovam in podjetjem, ki jih
potrebujejo pri svojem delu. Podjetja Lek d.d.,
Ljubljana; Krka d.d., Novo mesto in Helios d.d.,
Dom`ale, jih kot sovlagatelji pri nakupu osnovne
opreme NMR centra uporabljajo pri rutinski
analitiki in v okviru svojega raziskovalnorazvojnega
dela. V letu 2005 so instrumente v
okviru NMR centra na KI uporabljali tudi
raziskovalci iz podjetij Fenolit d.d., Borovnica;
Pliva d.d., Zagreb, Hrva{ka; Austrian Research
Center, Seibersdorf, Avstrija in Donau Chemie,
Brückl, Avstrija. Nekaj meritev smo opravili za
potrebe sodi{~a.
Raziskave v NMR centru so obsegale:
- {tudij strukture oligomernih fragmentov
nukleinskih kislin ter konformacijskih sprememb
gradnikov DNK ob interakciji s
kovinskimi ioni
- {tudij strukture in dinamike proteinov, zvijanja
proteinov in molekularnih interakcij peptidov
z lipopolisaharidi
- {tudij interakcij med ligandi in receptorjem
- {tudij strukture in dinamike antibiotikov v
povezavi z njihovim biolo{kim u~inkom
- raziskave strukture in dinamike organskih
molekul, detekcija in karakterizacija reaktivnih
intermediatov pri reakcijah organskih in
organokovinskih spojin
Nacionalni center za NMR spektroskopijo visoke lo~ljivosti - lokacija KI
National Centre for High Resolution NMR Spectroscopy - Location NIC
Zupet (Krka d.d., Novo mesto, Slovenia), Prof.
Dr. Ven~eslav Kau~i~ (National Institute of
Chemistry (NIC)), Dr. Jurka Kidri~ (NIC), Prof. Dr.
Daniel Kikelj (Faculty of Pharmacy, University of
Ljubljana, Slovenia), Dr. Mitja Kocjan~i~ (Agricultural
institute of Slovenia), Prof. Dr. Branko
Stanovnik (Faculty of Chemistry and Chemical
Technology, University of Ljubljana, Slovenia),
Dr. Zoran [u{teri~ (Sava d.d., Kranj, Slovenia),
and Dr. Milo{ Komac (Ministry of Higher Education,
Science and Technology).
In 2005 the cooperation between various research
groups and NMR centre at NIC involved
61 basic, applied and industrial projects as well
as international research projects. Research was
conducted by the following academic institutions
that are cofounders and coinvestors into
equipment of NMR centre: National Institute
of Chemistry; Institute Jozef Stefan, Ljubljana,
Slovenia; Faculty of Pharmacy and Faculty of
Chemistry and Chemical Technology, University
of Ljubljana and Agricultural Institute of
Slovenia. In the last few years cooperation of
NMR centre at NIC has been extended to colleagues
at National University Library; The
Slovenian Institute for Hop Research and Brewing;
Faculty of Natural Sciences and Engineering,
Faculty of Biotechnology and Medicinal
Faculty of University of Ljubljana, Slovenia and
Polytechnic, Nova Gorica, Slovenia. Instruments
are available to all institutions and companies
which apply NMR spectroscopy at their work.
Companies Lek d.d., Ljubljana, Slovenia; Krka
d.d., Novo mesto, Slovenia and Helios d.d.,
Dom`ale, Slovenia use NMR spectrometers as
analytical tool as well as in their research and
development projects. In 2005 NMR centre offered
services and help to companies Fenolit
d.d., Borovnica, Slovenia; Pliva d.d., Zagreb,
Hrva{ka; Austrian Research Center, Seibersdorf,
Austria and Donau Chemie, Brückl, Austria.
Research activities of NMR centre focused on:
- structure of oligomeric nucleic acids fragments
and conformational changes in DNA
building blocks upon interaction with metal
ions
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