Letno poročilo 2005
Letno poročilo 2005
Letno poročilo 2005
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Laboratorij za biotehnologijo<br />
Laboratory of Biotechnology<br />
PODRO^JA DEJAVNOSTI<br />
Raziskave v laboratoriju so usmerjene v raziskave<br />
biolo{kih procesov, kot sta prepoznavanje<br />
biolo{kih makromolekul in prenos signalov v<br />
celicah in imajo potencialno uporabnost<br />
(predvsem biotehnolo{ko, medicinsko, farmacevtsko).<br />
Pri tem uporabljamo moderne metode<br />
biokemije, molekularne biologije, mikrobiologije<br />
in biofizike.<br />
Raziskave s podro~ja medicine se nana{ajo na<br />
molekularne mehanizme sepse, konformacijskih<br />
bolezni in strukture amiloidov in delovanja<br />
antimikrobnih u~inkovin. Zanimajo nas mehanizmi<br />
prepoznavanja in biolo{ke aktivnosti na<br />
molekularni ravni, zlasti molekulskih vzorcev<br />
zna~ilnih za patogene mikroorganizme (PAMP),<br />
zato uporabljamo instrumentalne metode z<br />
visoko lo~ljivostjo in ob~utljivostjo, kot sta<br />
jedrska magnetna resonanca (NMR) in fluorescen~na<br />
spektroskopija. Raziskave vklju~ujejo<br />
{tudij fiziologije mikroorganizmov, ki izlo~ajo<br />
encime, organske kisline, antibiotike in druge<br />
zdravilne u~inkovine, kot tudi rekombinantne<br />
proteine. Laboratorij vzdr`uje mikrobiolo{ko<br />
zbirko (MZKI), v kateri hranimo ve~ kot 3000<br />
142<br />
RESEARCH ACTIVITIES<br />
Activity at the department is oriented towards<br />
research of the biochemical processes, particularly<br />
molecular recognition and signal transduction,<br />
and towards the application of modern<br />
biochemical, biotechnological, microbiological,<br />
biophysical and molecular biological methods<br />
to problems, which have potential industrial<br />
application in fields such as medicine, pharmacy<br />
or biotechnology.<br />
Research topics with application in medicine<br />
are molecular mechanisms of sepsis, conformational<br />
disease and antimicrobial activity of<br />
(lipo)peptides. We are interested in the mechanism<br />
of recognition of pathogen associated<br />
molecular patterns (PAMPs) at the molecular<br />
level where we are employing methods with<br />
high resolution such as nuclear magnetic resonance<br />
and fluorescence spectroscopy. Research<br />
interests include study of metabolic regulation<br />
in microorganisms, which are able to excrete a<br />
number of useful bioproducts, such as enzymes,<br />
organic acids, antibiotics and other pharmaceuticals,<br />
as well as recombinant proteins. Department<br />
hosts its own Microbial Culture Col-
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