Letno poročilo 2005

Nacionalni center za NMR spektroskopijo visoke lo~ljivosti - lokacija KI
National Centre for High Resolution NMR Spectroscopy - Location NIC
GLAVNI DOSE@KI V LETU 2005
In{talirali smo nov 800 MHz NMR spektrometer,
ki med drugim omogo~a ve~jo ob~utljivost in
lo~ljivost glede na obstoje~o opremo.
V teku je projekt Center odli~nosti, pri katerem
sodelujemo sodelavci KI, Leka in Krke in je
sofinanciran v okviru ukrepa 1.1 Evropskega
sklada za regionalni razvoj. Naslov tega
ambicioznega projekta je “NMR center odli~nosti
za {tudij struktur in interakcij v biotehnologiji
in farmaciji”. Raziskovalno-razvojne
usmeritve so zajete v 5 podsklopih oz. delovnih
paketih, s katerimi fokusiramo na{e aktivnosti
na naslednja znanstvena in raziskovalna
vpra{anja, ki se zelo tesno navezujejo na
konkretne probleme v farmacevtski industriji:
1.struktura in interakcije v trdnem stanju,
polikristalini~nost, polimorfizem,
2.struktura in analitika organskih spojin v
raztopini,
3.raziskave zmesi spojin v raztopini - profil
ne~isto~ v zdravilih, razpadni produkti,
metaboliti,
4.karakterizacija rekombinantnih proteinov in
biolo{kih makromolekul v raztopini in
5.interakcija zdravilnih u~inkovin z biolo{kimi
makromolekulami.
Raziskovalni dose`ki, ki so nastali v sodelovanju
NMR centra z raziskovalnimi laboratoriji in
skupinami {irom po Sloveniji so bili objavljeni v
preko 30 publikacijah v revijah z mednarodnim
recenzentskim sistemom (seznam je dostopen
na doma~i strani NMR centra na naslovu
www.nmr.ki.si). Precej{nje {tevilo teh dose`kov
je bilo objavljenih v revijah, ki segajo v sam vrh
znotraj posameznih podro~ij znanosti. Ti
dose`ki bodo posebej opisani med rezultati
posameznih laboratorijev na KI ali na drugih
in{titutih in fakultetah. Dose`ki sodelovanja
med NMR centrom in slovensko industrijo so
javno znani le preko uspe{nega poslovnega
rezultata posameznega podjetja.
170
2 Published Scientific Conference Contributions
14 Published Scientific Conference Contribution
Abstracts
2 Invited Lectures at Foreign Universities
1 Unpublished Invited Conference Lecture
1 Undergraduate Thesis
2 Doctoral Dissertations
IMPORTANT ACHIEVEMENTS IN 2005
Project Centre of Excellence prepared jointly by
researchers from NIC, Lek and Krka has been
approved.
The new 800 MHz NMR spectrometer has been
installed. We value among other aspects its
higher sensitivity and resolution.
The project of Centre of Excellence entitled
“NMR centre of excellence for the study of structures
and interactions in biotechnology and
pharmacy” is running in collaboration of researchers
from NIC, Lek and Krka and is cofinanced
by EU Structural Funds (action 1.1).
Research and development orientations are divided
into 5 sub-areas, or work-packages. These
areas are tightly linked to problems in the pharmaceutical
industry and will allow us to focus
our activities on the following scientific and
research questions:
1.Structure and interactions in solid state,
polycrystallinity, polymorphism,
2.Structural determination and analysis of organic
compounds in solution,
3.Studies of mixtures of compounds in solution
- profiling of impurities in medicines,
degradation products, metabolites,
4.Characterization of recombinant proteins and
biological macromolecules in solution,
5.Interaction of medically active compounds
with biological macromolecules.
Scientific achievements, which are the result of
cooperation of NMR center with laboratories
and groups around Slovenia were published in
over 30 publications in journals with international
peer review evaluation procedure (complete
list is available on NMR center’s home-