PhD thesis - University of Hertfordshire Research Archive

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year demonstrated that only the number of controls included (RR 1.42; 95%CI 1.03-1.94; P=0.031) and the number of variables investigated (RR 1.33; 95%CI 1.00-1.77; P=0.048) were independently associated with the number of risk factors identified. 165
Conclusions. Case-control studies of Campylobacter infection are increasing in size and complexity without the corresponding improvement in our understanding of disease transmission. The move towards larger studies are perhaps magnifying the biases inherent in the methodology. They appear to be influenced heavily by investigator and reporter bias, as evidenced by the disproportionate pursuit of the poultry hypothesis, which continues to explain only a fraction of cases, emphasising the need for more creative approaches to hypothesis generation. 166
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Population-Based Sentinel Surveilla
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The research carried out by the can
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Dedication. This thesis is dedicate
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7. Results (the published work). ..
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Statement identifying the degree fo
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Paper Reference Page 6 Gillespie IA
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Statement of the candidate’s cont
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Declaration form. I, Iain Andrew Gi
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2. History. In contrast to other co
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The application of veterinary techn
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The incidence of laboratory-confirm
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were elderly or had a pre-existing
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they would for other bacterial gast
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papers (Pearson et al., 1977; Bruce
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Studies were most frequently conduc
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The content of peer-reviewed public
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infection. An approximation of the
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hypotheses a „blank canvas‟ app
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6. Materials and methods. Regional
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presentation and severity, foreign
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together, etc). The results of the
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and improve response during the stu
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The published work. 7.1 Epidemiolog
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community illness was more common a
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north west England and in Yorkshire
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community was no different from oth
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provide useful insights into the ep
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Cases in case-control studies of la
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8. Discussion. The research carried
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The sentinel health authorities wer
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fundamentally flawed. Since the app
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control studies. The potential role
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Campylobacter spp. from cattle farm
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Cameron, S., Ried, K., Worsley, A.,
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Doyle, L. P. 1948, "The etiology of
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other industrialised countries," in
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Hanel, C. M. & Atanassova, V. 2007,
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Hudson, S. J., Lightfoot, N. F., Co
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Kessel, A. S., Gillespie, I., O'Bri
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costs-of-illness, Rijksinstituut vo
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Department of Health and Human Serv
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Potter, R. C., Kaneene, J. B., & Ha
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Siemer, B. L., Harrington, C. S., N
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Sopwith, W., Birtles, A., Matthews,
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Campylobacter infection: a general
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The published work 90
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PhD thesis - University of Hertfordshire Research Archive

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