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PhD thesis - University of Hertfordshire Research Archive

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Conclusions.<br />

Case-control studies <strong>of</strong> Campylobacter infection are increasing in size<br />

and complexity without the corresponding improvement in our<br />

understanding <strong>of</strong> disease transmission.<br />

The move towards larger studies are perhaps magnifying the biases<br />

inherent in the methodology.<br />

They appear to be influenced heavily by investigator and reporter bias,<br />

as evidenced by the disproportionate pursuit <strong>of</strong> the poultry hypo<strong>thesis</strong>,<br />

which continues to explain only a fraction <strong>of</strong> cases, emphasising the<br />

need for more creative approaches to hypo<strong>thesis</strong> generation.<br />

166

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