final program.qxd - Parallels Plesk Panel

PP 1.18
The spread of HIV-1 resistance mutations in the South of Russia
Shemshura A.B., Svechnikova L.V., Poddubskaya S.Y., Fomina N.G., Saukhat S.R.
Rostov Southern AIDS center, Rostov-on-Don, Russia
The aim of the study was the examination of drug-resistant HIV-1 strains in the South of
Russia. There was carried out sequencing of HIV-1 pol gene part coding of the revertase
in viral RNA samples in 22 HIV-infected patients (treated with HAART and untreated) from
the South Federal District of Russia.
Primary and secondary resistance mutations for NRTI and NNRTI were absent in
untreated patients in comparison with the other group of patients.
The treated patients showed differences in mutations in HIV-1 pol gene depending on the
degree of viral replication inhibition. It was found, that in successfully treated patients
?70R, M184V and K219Q mutations were registered more often, while in the patients with
the viral rebound - T215Y/F and L74V were registered more often. Together with this, the
lower CD4 count in the group of patients with unsuccessful viral replication inhibition was
marked.
Thus, our results testify that accumulation of resistance mutations in the HIV-1 pol gene
positions 215, 74, 103, 181, 41 as well as their combinations during HAART further the
efficiency decrease of NRTI and NNRTI included in HAART combination. To confirm this,
more extensive investigations should be taken.
“ Focusing FIRST on PEOPLE “ 102 w w w . i s h e i d . c o m