final program.qxd - Parallels Plesk Panel

FP 2.7
Hepatic steatosis in HIV and Hepatitis C virus coinfected patients receiving
antiretroviral therapy
MARTINEZ V. 1 , TA TDN.1, MOKHTARI Z. 1 , GUIGUET M. 2 , VALANTIN MA. 1 ,
CHARLOTTE F. 3 , BENHAMOU Y. 4 , CAUMES E. 1 , BRICAIRE F. 1 , KATLAMA C. 1
1.
Department of Infectious Diseases
2.
INSERM U7203. Anatomopathology4. HépatologyHôpital Pitié-Salpêtrière, 75013 Paris,
France
Background
To evaluate prevalence, severity of hepatic steatosis and to assess risk factors influencing
hepatic steatosis in HIV/HCV patients taking antiretroviral therapy (ART).
Methods
A retrospective study was conducted on HIV/HCV patients treated by ART, who underwent
liver biopsies from january 1995 to june 2005. All patients were negative for HBV testing
and never been treated for HCV. All liver biopsies were read by the same pathologist.
Hepatic steatosis was graded according to the percentage of hepatocytes affected:
0, none;1, steatosis involving 66%. Demographics and
laboratory parameters were recorded at time of hepatic biopsy.
Results
127 HIV/HCV coinfected patients were included. Median age was 39 years (35-43), 82%
were male, 89% were Caucasian, 78% had a past history of IV drug abuse.At the time of
biopsy, HIV viral load was suppressed (45 years, genotype 3
and abacavir use remained associated with decreased risk of hepatic steatosis.
Conclusion
Hepatic steatosis was present in 62% of HIV-HCV coinfected patients receiving ART.
In multivariate analysis, independent determinants of hepatic steatosis were
age>45 years, genotype 3 and abacavir use remained associated with decreased risk of
hepatic steatosis. Protective effect of abacavir, a non thymidinic drug group with less
mitochondrial damage, underlines the possible key role of DNA mitochondrial toxicity in
the genesis of steatosis and suggests opportunity to prevent hepatic steatosis in HIV and
HCV coinfected patients. Nevertheless, the role of drug classes and drugs within classes
should be investigated in prospective studies.
FREE ORAL PRESENTATIONS
“ Focusing FIRST on PEOPLE “ 267 w w w . i s h e i d . c o m