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final program.qxd - Parallels Plesk Panel

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FP 3.4<br />

Therapeutic Tat-Vaccination In Chronic HIV-Infection<br />

Daniel Zagury 1 , Hélène Le Buanec 1 , Patrick Larcier 1 , Arsene Burny 2 , Robert C. Gallo 3<br />

1<br />

Néovacs S.A., Université Pierre et Marie Curie, Paris, France<br />

2<br />

Université Libre de Bruxelles, Brussels, Belgium<br />

3<br />

Institute of Human Virology, University of Maryland, Baltimore, MD 21201-1192<br />

Basic epidemiological documentation as well as non human primate experimentation<br />

prompted us to develop anti Tat therapeutic vaccine based on Tat toxoid, a protein non<br />

toxic but immunogenic HIV-1 Tat derivative. Phase I trial conducted at the Hemophiliac<br />

Bonomi Center of Milan (Pr. Gringeri) in 1997-1998 and Phase I/II trial organized by<br />

Aventis Pasteur both at Hospital St-Pierre (Pr. Clumeck, Bruxelles) and at the IHV<br />

(Pr. R. Redfield, Baltimore) in 2001-2002 showed that the Tat toxoid immunogen<br />

adjuvanted with either Seppic oil (ISA51), DcChol or Alum was safe and immunogenic.<br />

A structured treatment interruption study (STI) monitored according to EU guidelines was<br />

conducted at Brussels (Pr. Clumeck) on the 31 vaccinees who received either a DcChol<br />

adjuvanted Tat Toxoid (n=12), a DcChol placebo (n=8) or non adjuvanted Tat Toxoid<br />

(n=11). This 2 year study showed that vaccines developing high titer of antibodies<br />

inhibiting Tat activity prolonged HAART-interruption.<br />

“ Focusing FIRST on PEOPLE “ 272 w w w . i s h e i d . c o m

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