final program.qxd - Parallels Plesk Panel

OP 3.5
Non-AIDS defining cancers in the era of HAART
Dr. Nancy Crum-Cianflone, San Diego - USA
Early in the HIV epidemic it was suggested that a second "epidemic" due to malignancies
may occur; this has been realized, and three cancers (Kaposi's sarcoma, non-Hodgkin's
lymphoma, and invasive cervical cancer) have been classified as AIDS-defining cancers
(ADCs). Since the advent of highly active antiretroviral therapy (HAART), the number of
opportunistic infections and ADCs (especially Kaposi's sarcoma) has dramatically
declined. However, the number of non-AIDS-defining cancers (NADCs) has
proportionally increased, and cancer remains a leading cause of morbidity and mortality
among HIV-infected persons. The reasons for the increase in NADCs includes
co-infection with oncogenic viruses, increased life expectancy, reduction of competitive
causes of death, and behaviors including tobacco use among this population Unlike
ADCs, NADCs do not correlate with the degree of immunosuppression. This lecture
describes trends in cancer incidence rates during the AIDS epidemic, reviews the most
common cancers in the era of HAART, and explores the pathogenesis of NADCs among
HIV-infected persons.
OP 4.1
New Antiretrovirals in the Pipeline:
from Already Known Targets to Integrase Inhibitors
No abstract available
“ Focusing FIRST on PEOPLE “ 44 w w w . i s h e i d . c o m