final program.qxd - Parallels Plesk Panel

PP 3.8
A Clinical Study Of 60 Patients Of Multidrug Resistant Tuberculosis in Mumbai,
India
Dr. Mohammad Khalid, Dr.Ganesh Rathod, Dr.Preeti Meshram.
Senior Resident,Resident,and Lecturer respectively.Mumbai,India.
Objectives
Tuberculosis is disease with a history as long as that of mankind.
In India 1/3rd of the population is infected with M. tuberculosis. Approximately 10% of the
infected population suffer from tuberculosis over 30-40 yrs. According to the Drug
Resistance Surveillance Programme conducted by WHO and IUATLD in 1995 the
prevalence of MDR - TB in India was 13-14 %.
Keeping the increasing trends of treatment failure cases in mind the study was conducted
at J.J.Hospital & Grant Medical College with the following objectives:
A. To study the clinical profile of presentation of MDR-TB
B. To study the resistance pattern and sputum conversion rate of MDR-TB.
C. To assess the bacteriological and radiological response to treatment.
METHODS
The Study was conducted from September 2003 to September 2005
I) All cases were resistant to Isoniazid & Rifampicin.
II) Detailed history was recorded
III) Patients were investigated with
a) Complete hemogram
b) Chest X ray
c) Sputum for AFB culture & Drug resistance testing
d) HIV
IV) Patients registered as MDR- TB were started on IInd line chemotherapy as per WHO
V) Follow up of patients was done every month for six months initially and then every three
months for sputum AFB microscopy and chest X-ray.
AFB culture was advised after nine months of treatment with IInd line drugs.
RESULTS
DISTRIBUTION OF MDR TB CASES
Pulmonary Extra Pulmonary
57 3
AGE WISE DISTRIBUTION
Age in years No of resistant cases Percentage
15-25 17 28.33
26-40 31 51.66
41-60 11 18.33
61-70 01 1.66
PATTERN OF RESISTANCE
SHREZ HREZ SHRE SHRZ HRE HRZ SHR HR
16 5 5 11 4 8 5 6
Percentage of resistance to individual drug
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