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final program.qxd - Parallels Plesk Panel

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SS 2.1<br />

The Lessons we have Learned over the Last Decade<br />

No abstract available<br />

SS 2.2<br />

Differentiating between Different Options<br />

No abstract available<br />

SS 2.3<br />

The Future of Therapy<br />

No abstract available<br />

SS 3.1<br />

Brain and HIV<br />

Jacques Gasnault, Kremlin-Bicêtre - France<br />

A greater number of patients over 50 years of age are now living with HIV in industrialized<br />

countries. This epidemiologic trend will continue to increase as a result of both prolonged<br />

survival due to effective antiretroviral treatment and the growing proportion of delayed<br />

diagnoses of older individuals with occult HIV disease. Despite a better virological<br />

response to combination antiretroviral therapy (cART), older patients are at a higher risk<br />

of HIV disease progression than youngers, for at least two reasons: first, they tend to be<br />

diagnosed at a more advanced stage; second, they have a delayed immune response to<br />

cART. There is emerging evidence that older HIV-infected individuals may be at greater<br />

risk for cognitive disorders. Some studies have identified a higher frequency of<br />

neurocognitive dysfunction in older than in younger HIV-infected persons. This impairment<br />

may vary in severity from a dementing illness (HIV-associated dementia) to a mild clinical<br />

change (minor cognitive motor disorders). Because of the overlap in cognitive functions<br />

that are affected by aging as well as by HIV-1 infection, one might expect that aging may<br />

potentiate the effects of HIV-1 on cognition in older individuals. In HIV-infected individuals<br />

as in general population, older age has been found to be associated with higher risk of<br />

complications as cardiovascular disease or diabetes, which can lead to a cognitive<br />

decline. The observation that HIV, advanced age, and concomitant neurodegenerative<br />

disorders as Alzheimer disease may interact in additive or synergistic ways raises many<br />

questions regarding best practice among this population.<br />

SS 3.2<br />

Long-Term Cardiovascular Troubles of HIV Patients<br />

No abstract available<br />

SS 3.3<br />

Cancer and HIV<br />

No abstract available<br />

“ Focusing FIRST on PEOPLE “ 280 w w w . i s h e i d . c o m

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