final program.qxd - Parallels Plesk Panel

PP 2.9
Immune restoration under HAART in patients chronically infected with HIV-1:
diversity of HIV avidity and T, B and NK immune responses
H. Le Guillou-Guillemette 1 , G. Renier 3 , B. Vielle 4 , P. Abgueguen 5 , J-M. Chennebault 5 ,
F. Lunel 1 , C. Payan 1,2 .
1
Laboratoire de Bactériologie-Virologie Centre Hospitalier Universitaire d'Angers, 4 rue
Larrey, 49033 Angers cedex, France. 2 Département de microbiologie,Centre Hospitalier
Régional Universitaire de Brest, Hôpital Morvan, 2 avenue Foch, 29609 Brest cedex
3
Laboratoire d'Allergologie-Immunologie Centre Hospitalier Universitaire d'Angers, 4 rue
Larrey, 49033 Angers cedex, France. 4Service de Biostatistiques Centre Hospitalier
Universitaire d'Angers, 4 rue Larrey, 49033 Angers cedex, France. 5 Service des Maladies
Infectieuses Centre Hospitalier Universitaire d'Angers, 4 rue Larrey, 49033 Angers cedex,
France.
Objectives
The aim of the study was to follow prospectively the humoral, cellular and innate immune
responses under HAART and to verify if a functional restoration of the B lymphocytes
could be evaluated by measuring the anti-HIV-1 IgG antibodies avidity index (AI).
Methods: Eleven HIV-1 infected and immunosuppressed patients were included in the
study. Viral load, naïve and memory B-cells, CD4 and CD8 T-cells and NK-cells counts,
and anti-HIV-1 IgG AI were determined during the follow-up (18 months).
Results
Ten patients were sustained responders under HAART and showed a quantitative
restoration of the CD4 T-cell counts (+269 x 106/L). The AI decreased for ten subjects
(-11%, p=0.006) but very slowly and continuously. A quantitative restoration of the
humoral immune response began, mainly concerning the naïve B-cells (+110 x 106/L).
Apart from one patient, the CD8 T-cell subset approached the reference values of healthy
subjects either by decreasing or increasing their cell levels. No homogeneous evolution
was described concerning the NK-cell subset, apart from trend towards increasing in
patients with opportunistic infection (range, +58 to +291 x 106/L).
POSTERS
Conclusion
Our study, which evaluated simultaneously for the first time to our knowledge the cellular,
humoral and innate immune responses showed that HAART induced a large diversity of
immune restoration patterns in responder patients. However, the AI measure appears to
be a weak marker to evaluate an immune restoration in chronic HIV-1 infected patients
under HAART.
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