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final program.qxd - Parallels Plesk Panel

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Thus, for some, HIV no longer produces a predictable death. Rather, with therapy HIV is<br />

often a chronic disease with far less morbidity. Furthermore, pediatric AIDS in the<br />

industrial world is almost over. However, the good news is quickly tempered by: (1) the<br />

emergence of HIV drug resistant mutants; (2) the toxicity of drugs when used and needed<br />

for years and probably for life-time; (3) the rise in cancer incidence in infected persons; (4)<br />

the increasing epidemic in some populations in Western nations; (5) the increasing<br />

numbers of doubly infected people with TB or HCV and HIV, and their worse prognosis;<br />

(6) the still considerable uncertainty of the future of the epidemic; (7) the lack of<br />

preventive vaccine; and (8) lastly, and most important, the dramatic epidemic in parts of<br />

the world that provide an enormous financial and infrastructure challenge.<br />

I will use this presentation to: (1) to discuss some of the lessons from the early period<br />

(before and just after AIDS, and subsequently HIV, were recognized); (2) summarize some<br />

of HIV's pathogenic mechanisms; (3) describe the drug therapy <strong>program</strong>s of the Institute<br />

of Human Virology with developing nations; and (4) outline a path to a preventive<br />

vaccine.<br />

“ Focusing FIRST on PEOPLE “ 275 w w w . i s h e i d . c o m

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