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PP 3.39 Faecal flora, diarrhoea associated with protease inhibitors in HIV-infected patients F. de Salvador-Guillouët, H. Carsenti-Dellamonica, X.Hebuterne, F.Girard-Pipau, J. Durant, P.Dellamonica Hôpital de l'Archet 1- service Infectiologie - BP 3079 - 06202 Nice cedex 3 Diarrhoea and abdominal pain with varying degrees of severity are frequent in HIVinfected patients and diarrhoea is one of the main causes of alteration of patients' quality of life. Objectives the aim of our study was to explore intestinal disorders associated with nelfinavir, a protease inhibitor (PI). Methods A prospective open study was conducted and included: 5 individuals with stool samples before and after treatment with nelfinavir (two healthy subjects and 3 HIV-infected patients), one untreated HIV-infected patient, 9 on treatment with nelfinavir during 1 month to 1 year and with varying degrees of intestinal dysfunction. A total of 20 stool samples were available and immediately frozen at -20°C (within less than 2 hours) Patients gave their informed consent Known bacterial or parasitic causes of diarrhoea were ruled out. Methods samples were analyzed for faecal flora by a gel-separation procedure for double stranded deoxyribonucleic acid (TGGE) and proteolytic activity was expressed as log10 of trypsin units that hydrolysed azocaseine per hour and per gram of faeces and determined in crude homogenate and soluble fraction. Results For treated HIV-infected patients, similarity percentage for TGGE before and after treatment was 86.7%. TGGE profiles were already disturbed and looked abnormal at the initial TGGE analysis study. PI did not appear to change the faecal flora significantly. Similarity percentage indicated a disturbance in faecal flora only in healthy subjects who took the treatment during three weeks. They did not have any diarrhoea, only soft stools. Proteolytic activity was enhanced in PI-naïve HIV-infected patients (9.4+3.6 and 4.5+2.0 logTrypsine U/ml) and decreased after = 2 months' nelfinavir treatment (6.3+1.4 and 2.6+0.08 logTrypsine U/ml) in crude homogenate and soluble fractions, respectively. The level of proteolytic activity was similar to that of healthy patients only after more than one month's treatment Conclusion this pilot study concerns a small number of samples due to difficulties in obtaining fresh stool samples. However HIV-infected patients appear to have a major disturbance of their faecal flora with high proteolytic activity prior to treatment that decrease after PI treatment. Our study suggests that an independent factor may have altered the flora before both samples were taken. Such elevated levels of faecal proteases in this disease may play a role in subsequent damage of the intestinal mucosa. These preliminary results merit further investigation. “ Focusing FIRST on PEOPLE “ 180 w w w . i s h e i d . c o m
PP 4.1 Evaluation of a Triple Therapy Associating 2 NRTI + EFAVIRENZ Versus 2 NRTI + INDINAVIR in HIV-1 Positive patients with Less than 100 CD4/mm 3 AT Initiation TANON A 1 , EHOLIE S 1 , ELLOH F 1 , DJADJI A 1 , KANGAH C 2 , CHENAL H 3 , BISSAGNENE E 1 , KADIO A 1 . 1 Infectious and tropical diseases department - BP V 3 CHU de Treichville - Abidjan - Côte d'Ivoire. 2 Ambulatory Care and counseling Unit of Abidjan 3 Center of Bioclinical Research of Abidjan Backgrounds To compare the therapeutic efficiency, the tolerance and the adherence of 2 therapeutics; the association of 2 INRT + efivarenz (EFV) versus 2 INRT + Indinavir (IDV) to immuno depressed patients having a rate of CD4
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EDITORIAL Dear Madam, Dear Sir, It
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PRACTICAL INFORMATION - INFORMATION
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PROGRAM AT A GLANCE “ Focusing FI
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WEDNESDAY JUNE 21, 2006 - MERCREDI
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WEDNESDAY JUNE 21, 2006 - MERCREDI
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THURSDAY JUNE 22, 2006 - JEUDI 22 J
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THURSDAY JUNE 22, 2006 - JEUDI 22 J
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FRIDAY JUNE 23, 2006 - VENDREDI 23
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POSTERS PRESENTATIONS - PRESENTATIO
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The hospital reform in progress may
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OP 1.3 Public Health and Social Sci
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OP 2.1 Research Priorities in HIV :
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OP 2.3 Research Priorities In HIV I
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OP 3.2 Interactions between HSV and
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OP 3.4 Fertility options in HIV-inf
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OP 3.5 Non-AIDS defining cancers in
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OP 4.3 Update on TMC114 - Actualit
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OP 4.5 Recent data on PA-457 Matura
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OP 5.3 Immunology - Summary of adva
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OP 6.2 Molecular Epidemiology of HI
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In 1995 HIV started to spread rapid
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Given the high HIV prevalence in ID
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OP 6.4 The Epidemiology of HIV & ST
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OP 7.3.1 We must switch early patie
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OP 7.4.2 Entry inhibitors have to b
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OP 8.2 West Nile Virus Infection in
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First, the origin of primary introd
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To reduce the amount of virus that
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OP 9.1 New Developments in the Trea
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OP 9.3 Future options in non respon
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the consensus interferon dose (25,2
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interferon maintenance therapy in d
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26) Kaiser S, Hass HG, Gregor M. Su
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OP 10.1 Progress in Microbicide Dev
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OP 10.3 Current Advances in HIV Vac
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dysmetabolic, functional, or organi
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Orphans Forty-three percent of the
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PP 1.4 Pradip Timilsena, Laxmi Pras
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PP 1.6 Epidemiological aspects of M
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PP 1.8 HIV transmission in The Gamb
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PP 1.10 Evaluation of Prevalence an
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PP 1.12 Co-morbidity of HIV, Hepati
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PP 1.14 Screening for HIV-infection
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PP 1.16 Low performance of HIV-1 se
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PP 1.18 The spread of HIV-1 resista
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PP 1.20 Study of the anti-HIV recom
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PP 1.22 Comparative investigation o
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PP 1.24 Foreign Citizens Admitted t
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PP 1.26 Morbidity pattern of PLWA r
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PP 1.28 Incidence of Atypical Mycob
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PP 1.29 Developing Partnerships Bet
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PP 1.31 Pakistani Youth and their R
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PP 1.33 Model based on a quantum al
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PP 2.2 Analysis of Full-length HIV-
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PP 2.4 The Cobas Ampliprep/Cobas Ta
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PP 2.6 Mutations and Polymorphisms
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PP 2.8 Differences in the phenotypi
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PP 2.10 Biochemical Characterizatio
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Page 132 and 133: PP 2.13 Assessing the Contribution
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Page 136 and 137: PP 2.17 Interface targeting peptide
Page 138 and 139: PP 2.19 HIV-1 gene expression: less
Page 140 and 141: PP 2.21 Vesical Cancer and Papillom
Page 142 and 143: PP 3.2 Is Age a Complicating Factor
Page 144 and 145: PP 3.4 Reversible HIV associated en
Page 146 and 147: PP 3.6 Mycobacterium Ulcerans Cutan
Page 148 and 149: PP 3.8 A Clinical Study Of 60 Patie
Page 150 and 151: PP 3.9 HIV and Tuberculosis: Partne
Page 152 and 153: PP 3.11 Clinicopathological compari
Page 154 and 155: PP 3.13 Crohn's disease onset in a
Page 156 and 157: PP 3.15 Ocular manifestations occur
Page 158 and 159: PP 3.17 Bladder carcinoma observed
Page 160 and 161: PP 3.19 Increasing concerns related
Page 162 and 163: PP 3.21 Glucose intolerance and ins
Page 164 and 165: PP 3.23 Proviral DNA and plasma vir
Page 166 and 167: PP 3.25 Frequency, monitoring, clin
Page 168 and 169: PP 3.27 HIV-positive cases as part
Page 170 and 171: PP 3.29 The Effects of a Supervised
Page 172 and 173: PP 3.31 Prevalence of depression am
Page 174 and 175: PP 3.33 Rhinopharyngeal carcinoma w
Page 176 and 177: PP 3.35 Large vessel damage due to
Page 178 and 179: PP 3.37 No Interference between Syp
Page 182 and 183: PP 4.2 Triple therapy adherence in
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Page 186 and 187: PP 4.5 A Prospective Study of Antir
Page 188 and 189: PP 4.7 Telephone-Based Coping Impro
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Page 192 and 193: PP 4.11 Self-Evaluation Investigati
Page 194 and 195: PP 4.13 Treatment of Kaposi's sarco
Page 196 and 197: PP 4.15 Pharmacokinetic Interaction
Page 198 and 199: PP 4.17 Human immunodeficiency viru
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Page 202 and 203: PP 4.21 No evidence of reduced viro
Page 204 and 205: PP 4.23 The increased liver toxicit
Page 206 and 207: PP 4.25 Rapid Oral Desensitization
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Page 212 and 213: PP 5.5 Fulminant Candida albicans p
Page 214 and 215: PP 5.7 Chronic hepatitic C-prompted
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Page 218 and 219: PP 6.2 Broadly protective immunity
Page 220 and 221: PP 6.4 Chikungunya arthritis sequel
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Page 224 and 225: PP 6.7 Emerging Arboviruses in Turi
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PP 6.13 Evaluation of the Prevalenc
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PP 6.15 Assessment of need of Patie
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PP 6.17 Community-acquired septicem
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PP 6.19 Multiple sclerosis managed
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PP 6.21 A serious staphylococcal kn
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PP 6.23 Comparison between Secretor
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PP 6.25 Real- Time PCR and Flow Cyt
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FP 0.2 Preclinical Development of a
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FP 0.4 Primary Resistance of a Nove
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FP 1.1 In Vivo Emergence of RANTES-
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Conclusion:Patients with HIV-1 infe
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FP 1.4 V1V2 loop length variation d
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FP 1.6 Analysis of plasma cytokines
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FP 1.8 Detection of low frequency H
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FP 1.10 Replication-Competent Platf
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FP 2.1 Long-term non-progression in
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FP 2.3 HAART in Sub-Saharan countri
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FP 2.5 Morbidity and mortality by b
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FP 2.6 Tolerability of antiretrovir
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FP 2.8 Radata - An internet-based s
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FP 3.2 Glycosylated recombinant sim
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FP 3.4 Therapeutic Tat-Vaccination
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PL 2 HIV & AIDS Research: The Light
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SS 1.1 The importance of HIV drug r
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SS 1.3 Virtual phenotype and Clinic
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SS 2.1 The Lessons we have Learned
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SS 5.2 HIV-associated facial lipoat
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SS 6.1 How to improve the use of ne
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SS 6.3 Tipranavir is a Potent Prote
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ABBOTT FRANCE Abbott is a global, b
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BOEHRINGER INGELHEIM The Boehringer
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IVAGEN IVAGEN SA, a biotechnology c
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ROCHE Headquartered in Basel, Switz
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Putting knowledge into practice VIR
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NOTES “ Focusing FIRST on PEOPLE
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