final program.qxd - Parallels Plesk Panel

FP 1.2
Natural Suppressors, HIV-1 Viral Suppression in the Absence of Therapy
Sajadi MM, Heredia A, Le N, Chan-Tack K, Constantine NT, DeVico A, Redfield R.
Institute of Human VirologyUniversity of MarylandBaltimore, Maryland
Objectives:HIV Natural Suppressors (NS) are individuals with HIV-1 that are able to
completely suppress HIV viral replication in the absence of antiretroviral therapy. By
contrast, Long-Term Nonprogressors (LTNP), represent individuals who are HIV-1
infected but who maintain immunologic function over many years (no where in the de
finition of LTNPs is viral load considered, and in most series the HIV-1 viral loads range
from 102 to 104 copies/ml). We present here the largest and most detailed study of such
patients that has been undertaken, characterizing the host and viral factors that make
these patients unique.
Methods:Inclusion/Exclusion Criteria:1) HIV-1 positive by Western Blot2) Viral loads 400, allowed per every 10 times viral load
checked).3) No more than 2 weeks of ART use, unless during pregnancy
Studies: included PCR for HLA Typing, PCR for the CCR5 delta-32 mutation, High Input
PCR for Proviral DNA copy number, HIV-1 virus isolation, Neutralization antibody tests,
chemokine activity, and replication kinetics (PBMCs infected with 3B and JRCSF strains
at moi of .0001 and .001).
Results:40 patients were identified as NS, and 22 have been enrolled. A prevalence rate
of 1.5% NS in our clinic population was calculated. Demographics are shown in the table
below.
Age 51 (range 38-59)
Sex Male-55% Female-45%
Race
African-American-100%
Median years with HIV 8.5 (range .5-18)
Median years viral suppression 5 (range .5-9)
Median of latest CD4 count (cells/ul) 970 (range 523-1342)
Average number of viral loads