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PP 3.3<br />

Opportunistic infections associated to a late, first diagnosis of AIDS. Paradoxical<br />

increase of frequency at the time of highly active antiretroviral therapy (HAART)<br />

Roberto Manfredi, Leonardo Calza<br />

Infectious Diseases, University of Bologna, Italy<br />

Introduction<br />

Notwithstanding the availability of HAART, AIDS notifications continue to occur, with<br />

increasing prevalence for patients (p) who missed or neglected their condition.<br />

Patients and Methods<br />

All cases of AIDS notified since the year 2001 were compared with those found in the<br />

decade preceding HAART availability (1986-1995).<br />

Results<br />

Compared with the pre-HAART era, a significant drop of frequency of overall AIDS cases<br />

occurred: from a mean 58.3±11.2 patients-year observed in the decade 1986-1995, to<br />

14.2±6.0 patients-year from 2001 to 2005 (p

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