final program.qxd - Parallels Plesk Panel

Conclusion: In this cohort of West African adults who participated in the pre-randomisation
phase of a STI trial and who thus started HAART at early stage of immunosuppression,
the rate of severe morbidity during the first months following HAART initiation was higher
than expected, including in patients with baseline CD4 > 350/mm 3 . We were not able to
estimate which proportion of severe morbidity was associated with the immune
reconstitution syndrome. The hypothesis that HAART should be started earlier in
sub-Saharan Africa than in industrialized countries because of specific spectrum of early
morbidity deserves further consideration.
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