final program.qxd - Parallels Plesk Panel

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Conclusion:Patients with HIV-1 infection who are able to naturally suppress HIV infection in tbe absence of therapy represent one particular extreme of HIV infected patients and are a distinct entity that may yield insight into the virus-host interaction and pathogenesis of HIV-1 infection. Although these patients share some features with LTNPs (HLAB57 status, CCR5 heterozygosity), the striking finding in this study is the degree of resistance to HIV-infection of PBMCs. Further studies are ongoing to determine the exact mechanism of this resistance. “ Focusing FIRST on PEOPLE “ 250 w w w . i s h e i d . c o m
FP 1.3 An in vitro System for HIV-1 Selective Transmission using Human Genital Epithelial cells Z.W. Wu 1 , G.F. Fu 1 , Y.Y. Hou 1 , and Z.W. Chen 2 1 Center for Public Health Research, Nanjing University, Nanjing, China; 2 Aaron Diamond AIDS Research Center, New York, USA Objectives An in vitro culture system, using human genital epithelial cell lines, was established for investigating HIV-1 sexual transmission. The system was used to study the efficiency of CCR5 and CXCR4 virus transfer from the epithelial cells to CD4+ cells and the mechanisms of selective transmission during sexual transmission of HIV-1. Methods Ect1, End1 and VK2 are HPV E6/E7 gene-transformed human ectocervical, endocervical and vaginal epithelial cell lines, respectively. These cells formed monolayers in culture, with morphology similar to their corresponding tissues. The culture monolayers were pulsed with CCR5 or CXCR4 using HIV-1 and washed off unbound viruses. H9 cells or IL-2-stimulated human PBMCs were co-cultured with the monolayers for 18 hours, recovered and then re-cultured for a period of 6-9 days. Virus production was monitored sequentially and the relative transmission efficiency of CCR5 and CXCR4 viruses was investigated. Results All three epithelial cell lines were refractory to HIV-1 infection due to the lack of CD4 expression. However, virus can efficiently adsorbed to the epithelial monolayers via heparin sulfate moiety of proteoglycans and remained infectious for up to 9 days in culture. The adsorption and releasing of CCR5 and CXCR4 viruses were not significantly different. Upon co-culture with IL2-stimulated human PBMCs, CCR5 virus was efficiently transmitted and replicated in the PBMCs. To the contrary, CXCR4 virus was poorly transmitted and replicated though evidence showed that the virus was not defective since it replicated well when a T cell line (H9) was used. Preliminary studies showed that the differential replication of CCR5 and CXCR4 viruses in PBMCs did not account for the differences of CCR5 and CXC4 viruses in co-cultured PBMCs, suggesting that CXCR4 virus was blocked during the transfer from the epithelial cells to the PBMCs. Conclusions 1. The human genital epithelial cell-based in vitro culture system is a suitable tool for investigating the mechanisms of HIV-1 sexual transmission; 2. CCR5 and CXCR4 viruses were differentially transmitted from the epithelial cells to IL-2-stimulated human PBMCs with CXCR4 virus largely blocked during the co-culture; 3. The epithelial-PBMCs interface may play important roles in selecting virus transmission and this co-culture system may serve to delineate the molecular mechanisms of viral sexual transmission. FREE ORAL PRESENTATIONS “ Focusing FIRST on PEOPLE “ 251 w w w . i s h e i d . c o m
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EDITORIAL Dear Madam, Dear Sir, It
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PRACTICAL INFORMATION - INFORMATION
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PROGRAM AT A GLANCE “ Focusing FI
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WEDNESDAY JUNE 21, 2006 - MERCREDI
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WEDNESDAY JUNE 21, 2006 - MERCREDI
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THURSDAY JUNE 22, 2006 - JEUDI 22 J
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THURSDAY JUNE 22, 2006 - JEUDI 22 J
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FRIDAY JUNE 23, 2006 - VENDREDI 23
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POSTERS PRESENTATIONS - PRESENTATIO
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The hospital reform in progress may
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OP 1.3 Public Health and Social Sci
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OP 2.1 Research Priorities in HIV :
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OP 2.3 Research Priorities In HIV I
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OP 3.2 Interactions between HSV and
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OP 3.4 Fertility options in HIV-inf
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OP 3.5 Non-AIDS defining cancers in
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OP 4.3 Update on TMC114 - Actualit
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OP 4.5 Recent data on PA-457 Matura
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OP 5.3 Immunology - Summary of adva
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OP 6.2 Molecular Epidemiology of HI
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In 1995 HIV started to spread rapid
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Given the high HIV prevalence in ID
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OP 6.4 The Epidemiology of HIV & ST
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OP 7.3.1 We must switch early patie
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OP 7.4.2 Entry inhibitors have to b
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OP 8.2 West Nile Virus Infection in
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First, the origin of primary introd
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To reduce the amount of virus that
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OP 9.1 New Developments in the Trea
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OP 9.3 Future options in non respon
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the consensus interferon dose (25,2
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interferon maintenance therapy in d
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26) Kaiser S, Hass HG, Gregor M. Su
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OP 10.1 Progress in Microbicide Dev
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OP 10.3 Current Advances in HIV Vac
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dysmetabolic, functional, or organi
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Orphans Forty-three percent of the
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PP 1.4 Pradip Timilsena, Laxmi Pras
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PP 1.6 Epidemiological aspects of M
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PP 1.8 HIV transmission in The Gamb
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PP 1.10 Evaluation of Prevalence an
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PP 1.12 Co-morbidity of HIV, Hepati
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PP 1.14 Screening for HIV-infection
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PP 1.16 Low performance of HIV-1 se
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PP 1.18 The spread of HIV-1 resista
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PP 1.20 Study of the anti-HIV recom
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PP 1.22 Comparative investigation o
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PP 1.24 Foreign Citizens Admitted t
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PP 1.26 Morbidity pattern of PLWA r
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PP 1.28 Incidence of Atypical Mycob
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PP 1.29 Developing Partnerships Bet
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PP 1.31 Pakistani Youth and their R
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PP 1.33 Model based on a quantum al
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PP 2.2 Analysis of Full-length HIV-
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PP 2.4 The Cobas Ampliprep/Cobas Ta
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PP 2.6 Mutations and Polymorphisms
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PP 2.8 Differences in the phenotypi
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PP 2.10 Biochemical Characterizatio
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Upon 60 minutes contact of BVDV spi
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PP 2.13 Assessing the Contribution
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PP 2.15 Correlation between circula
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PP 2.17 Interface targeting peptide
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PP 2.19 HIV-1 gene expression: less
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PP 2.21 Vesical Cancer and Papillom
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PP 3.2 Is Age a Complicating Factor
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PP 3.4 Reversible HIV associated en
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PP 3.6 Mycobacterium Ulcerans Cutan
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PP 3.8 A Clinical Study Of 60 Patie
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PP 3.9 HIV and Tuberculosis: Partne
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PP 3.11 Clinicopathological compari
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PP 3.13 Crohn's disease onset in a
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PP 3.15 Ocular manifestations occur
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PP 3.17 Bladder carcinoma observed
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PP 3.19 Increasing concerns related
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PP 3.21 Glucose intolerance and ins
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PP 3.23 Proviral DNA and plasma vir
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PP 3.25 Frequency, monitoring, clin
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PP 3.27 HIV-positive cases as part
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PP 3.29 The Effects of a Supervised
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PP 3.31 Prevalence of depression am
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PP 3.33 Rhinopharyngeal carcinoma w
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PP 3.35 Large vessel damage due to
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PP 3.37 No Interference between Syp
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PP 3.39 Faecal flora, diarrhoea ass
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PP 4.2 Triple therapy adherence in
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In a hierarchical multiple regressi
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PP 4.5 A Prospective Study of Antir
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PP 4.7 Telephone-Based Coping Impro
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PP 4.9 The significantly different
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PP 4.11 Self-Evaluation Investigati
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PP 4.13 Treatment of Kaposi's sarco
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PP 4.15 Pharmacokinetic Interaction
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PP 4.17 Human immunodeficiency viru
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Page 246 and 247: FP 0.4 Primary Resistance of a Nove
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Page 254 and 255: FP 1.6 Analysis of plasma cytokines
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Page 260 and 261: FP 2.1 Long-term non-progression in
Page 262 and 263: FP 2.3 HAART in Sub-Saharan countri
Page 264 and 265: FP 2.5 Morbidity and mortality by b
Page 266 and 267: FP 2.6 Tolerability of antiretrovir
Page 268 and 269: FP 2.8 Radata - An internet-based s
Page 270 and 271: FP 3.2 Glycosylated recombinant sim
Page 272 and 273: FP 3.4 Therapeutic Tat-Vaccination
Page 274 and 275: PL 2 HIV & AIDS Research: The Light
Page 276 and 277: SS 1.1 The importance of HIV drug r
Page 278 and 279: SS 1.3 Virtual phenotype and Clinic
Page 280 and 281: SS 2.1 The Lessons we have Learned
Page 282 and 283: SS 5.2 HIV-associated facial lipoat
Page 284 and 285: SS 6.1 How to improve the use of ne
Page 286 and 287: SS 6.3 Tipranavir is a Potent Prote
Page 288 and 289: ABBOTT FRANCE Abbott is a global, b
Page 290 and 291: BOEHRINGER INGELHEIM The Boehringer
Page 292 and 293: IVAGEN IVAGEN SA, a biotechnology c
Page 294 and 295: ROCHE Headquartered in Basel, Switz
Page 296 and 297: Putting knowledge into practice VIR
Page 298: NOTES “ Focusing FIRST on PEOPLE
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