final program.qxd - Parallels Plesk Panel

PP 2.21
Vesical Cancer and Papillomavirus : Homology between bovine Papillomavirus type
2 (BPV-2) E6 and mdm2 oncogene
Caprani A *, Tran MKG* 1
*Association "Positifs", Paris 1 Université Paris V
Introduction
Metastatic bladder cancer are not easily to treat. More fundamental researches are
necessary to understand their physiopathology. Among the environmental causes (aniline,
tobacco), viruses are paucily explored. Campo M.S. has demonstrated that bladder
cancer occurs spontaneously in Scottish cows infected with BPV-2 and can also be
induced experimentally by BPV-2.
Objective
To elucidate the mechanism of BPV-2 oncogenesis in bladder cancer.
Method
To analyse the amino acid sequences of bovine and human papillomaviruses and
compare them to various oncogenes, especially mdm2, which binds to the tumor
suppressor p53, and is overexpressed in some bladder cancers (Lianes P., 1994).
Results:
BPV-5 E6 PKD VLGR G CYYC
Mdm 2 RL DEKQQHIVY PKN IVHGKT -GHL-MACFT-
CAKKLKK
BPV-2 E6 KL NEKQRHVLY LLHGKSLDRLCIRCCYCGGKLTK
BPV-1 E6
T
HPV- 14, 21, 20 E6 V GKS V CYTC K L
The motif GKT or GKS is an ATPase motif which binds phosphate PO4. In mdm2, the
sequence KKLKK is a nuclear localizing signal.
Conclusion
Bladder cancer may be of viral origin, because bovine papillomavirus type 2 represent an
experimental model (Campo M.S.) very similar to human disease. We found that BPV-2
E6 oncogene is homologous to mdm2 oncogene, overexpressed in some bladder
cancers. Thus it would be interesting to research more systematically papillomaviruses in
human bladder cancer, particularly those which are metastatic.
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