EMQs in Clinical Medicine.pdf - Peshawar Medical College

3 Haematology and oncology
QUESTIONS
20 Causes of anaemia
A
B
C
D
E
F
autoimmune haemolytic
anaemia
spherocytosis
pyruvate kinase deficiency
aplastic anaemia
thalassaemia minor
glucose-6-phosphate dehydrogenase
deficiency
G
H
I
J
K
L
thalassaemia
iron deficiency anaemia
sickle-cell anaemia
folate deficiency
sideroblastic anaemia
pernicious anaemia
For each clinical scenario below, give the most likely cause for the clinical
findings. Each option may be used only once.
1 A 23-year-old man presents with recurrent nose-bleeds and infection after a
course of chemotherapy.
2 A 24-year-old Cypriot man presents with a worsening anaemia and jaundice.
A blood film taken several weeks after the incident shows the presence of Heinz
bodies.
3 A 50-year-old man presents with tiredness, dyspnoea and paraesthesia. On
examination he showed extensor plantars, brisk knee jerks and absent ankle
jerks. His blood film shows macrocytic anaemia.
4 A 23-year-old woman on trimethoprim for recurrent urinary tract infections
(UTIs) presents with a macrocytic anaemia.
5 A 25-year-old woman with systemic lupus erythematosus (SLE) presents with an
acute anaemia. She was successfully treated with steroids. Direct Coombs’ test
was strongly positive; direct antiglobulin test was positive with IgG alone.
Answers: see page 60.