EMQs in Clinical Medicine.pdf - Peshawar Medical College

Tumour markers 57
25 Tumour markers
A
B
C
D
PSA (prostate-specific antigen)
ADH
calcitonin
-hCG (-human chorionic
gonadotrophin)
E CA 19-9
F CA 15-3
G
H
I
J
K
L
AFP (-fetoprotein)
ANP
5 HIAA
urinary catecholamines
PTH
CEA (carcinoembryonic antigen)
For each of the presentations of cancer below, suggest the tumour marker that is
most likely to be elevated.
1 A 60-year-old man presents with poor stream, weight loss and back pain. Digital
rectal examination reveals a hard irregular prostate gland.
2 A 65-year-old woman with weight loss and painless jaundice. There is evidence
of thrombophlebitis migrans and computed tomography (CT) shows a mass in
the pancreatic head.
3 A 70-year-old man presenting with a suspected recurrence of colorectal
carcinoma.
4 A 68-year-old person with chronic alcohol problems and hepatocellular
carcinoma.
5 A 34-year-old man is referred to radiotherapy with seminoma.
Answers: see page 66.