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Kravtsov V, Swain M, Schuster A, Dubitzky W and Dubin U; Grid computing solutions for distributed repositories ofprotein folding and unfolding simulations, in Proceedings of the International Conference on Computational Science (ICCS2008), Poland, 274-283, 2008Sánchez A, Montes J, Dubitzky W, Valdés JJ, Pérez MS & de Miguel P; Data Mining Meets Grid Computing: Time toDance? in W. Dubitzky (editor); Data Mining Techniques in Grid Computing Environments, Wiley, pp. 1-16, 2008Stankovski V, Swain M, Kravtsov V, Niessen T, Wegener D, Röhm M, Trnkoczy J, May M, Franke J, Schuster A & DubitzkyW; Digging Deep into the Data Mine with DataMiningGrid; IEEE Internet Computing, 12: 69-76, 2008Stankovski V, Swain M, Kravtsov V, Niessen T, Wegener D, Kindermann J & Dubitzky W; Grid-enabling data miningapplications with DataMiningGrid: An architectural perspective; Future Generation Computer Systems, 24: 259–279,2008Swain M, Mandel JJ and Dubitzky W; Comparing Grid Computing Solutions for Reverse-Engineering Gene RegulatoryNetworks, in Proceedings of the International Conference on Computational Science (ICCS 2008), Poland, 106-115, 2008Swain M, Ostropytskyy V, Silva CG, Stahl F, Riche O, Brito RMM, Dubitzky W; Grid Computing Solutions for DistributedRepositories of Protein Folding and Unfolding Simulations; Proceedings of the International Conference on ComputationalScience (ICCS 2008), Krakow, Poland, 70-79, 2008Gulyas L, de Back W, Szemes G, Kurowski K, Dubitzky W and Kampis G; Templates for Distributed Agent-BasedSimulations, 20th European Modeling and Simulation Symposium, September 2008, Briatico, Italy, 2008 (in press)Professor Bert SakmannProfessor of Biomedical SciencesThe appointment of the Nobel Prize-winning scientist, Professor Bert Sakmann, in 2007 was hailed as a coup forthe University of Ulster and further recognition of its continued emphasis and commitment to research excellence.Professor Sakmann was awarded the 1991 Nobel Prize for Physiology, with his research partner Erwin Neher, fortheir discoveries ‘concerning the function of single ion channels in cells’.Professor Sakmann is leading a pioneering research project into the nature of nerve cells, the main aim of which isto learn more about how the brain processes information. This project is being conducted by Professor Sakmann’sNeurobiology laboratory at the Max Planck Institute (Munich) in conjunction with the Biomedical Sciences ResearchInstitute (BMSRI) and other major research centres. Researchers within the BMSRI, led by Dr Kurt Saetzler, havedeveloped software that will be used to analyse research data arising from this project. It is hoped that the softwareand its 3D imaging facility developed at Ulster will help identify “building blocks” that influence brain mechanisms thatenable us to make decisions, to learn and to memorise and this should provide even deeper insights into patterns inhuman brain activity.Professor Sakmann delivered a special public lecture entitled: ”Decision-making: anatomy and physiology in the cerebralcortex”, at the Coleraine campus in October 2008 to mark his tenure as Professor of Biomedical Sciences atUlster.Professor Sakmann is interested in using computerised or so-called in silico models to simulate how neuronscommunicate with each other. This will contribute significantly to our future understanding on how we thinkand memorise and is at the forefront of international research in Neuroscience as documented by below list ofpublications.100
Publications:Frick A, Feldmeyer D, Sakmann B; Postnatal development of synaptic transmission in local networks of L5A pyramidalneurons in rat somatosensory cortex; Journal of Physiology, 585: 103-116, 2007Helmstaedter M, de Kock CP, Feldmeyer D, Bruno RM, Sakmann B; Reconstruction of an average cortical column insilico; Brain Research Reviews, 55: 193-203, 2007Kerr JN, de Kock CP, Greenberg DS, Bruno RM, Sakmann B, Helmchen F; Spatial organization of neuronal populationresponses in layer 2/3 of rat barrel cortex; Journal of Neuroscience, 27:13316-13328, 2007Krieger P, Kuner T, Sakmann B; Synaptic connections between layer 5B pyramidal neurons in mouse somatosensorycortex are independent of apical dendrite bundling; Journal of Neuroscience, 27: 11473-11482, 2007Larkum ME, Waters J, Sakmann B, Helmchen F; Dendritic spikes in apical dendrites of neocortical layer 2/3 pyramidalneurons; Journal of Neuroscience, 27: 8999-9008, 2007Oberlaender M, Bruno RM, Sakmann B, Broser PJ; Transmitted light brightfield mosaic microscopy for three-dimensionaltracing of single neuron morphology; Journal of Biomedical Optics, 12: 064029, 2007Sarid L, Bruno R, Sakmann B, Segev I, Feldmeyer D; Modeling a layer 4-to-layer 2/3 module of a single column in ratneocortex: interweaving in vitro and in vivo experimental observations; Proceedings of the National Academy of Sciences(USA), 104: 16353-16358, 2007Tan HO, Reid CA, Single FN, Davies PJ, Chiu C, Murphy S, Clarke AL, Dibbens L, Krestel H, Mulley JC, Jones MV,Seeburg PH, Sakmann B, Berkovic SF, Sprengel R, Petrou S; Reduced cortical inhibition in a mouse model of familialchildhood absence epilepsy; Proceedings of the National Academy of Sciences (USA), 104: 17536-17541, 2007Broser P, Grinevich V, Osten P, Sakmann B, Wallace DJ; Critical period plasticity of axonal arbors of layer 2/3 pyramidalneurons in rat somatosensory cortex: layer-specific reduction of projections into deprived cortical columns;Cereb Cortex, 18: 1588-1603, 2008Broser PJ, Erdogan S, Grinevich V, Osten P, Sakmann B, Wallace DJ; Automated axon length quantification for populationsof labelled neurons; Journal of Neurosci Methods, 169: 43-54, 2008de Kock CP, Sakmann B; High frequency action potential bursts (>or= 100 Hz) in L2/3 and L5B thick tufted neuronsin anaesthetized and awake rat primary somatosensory cortex; Journal of Physiology, 586: 3353-3364, 2008Frick A, Feldmeyer D, Helmstaedter M, Sakmann B; Monosynaptic connections between pairs of L5A pyramidalneurons in columns of juvenile rat somatosensory cortex; Cereb Cortex, 18:397-406, 2008Voigts J, Sakmann B, Celikel T; Unsupervised whisker tracking in unrestrained behaving animals; Journal of Neurophysiology,100: 504-515, 2008Wallace DJ, Sakmann B; Plasticity of representational maps in somatosensory cortex observed by in vivo voltagesensitivedye imaging; Cereb Cortex, 18: 1361-1373, 2008101
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BIOMEDICAL SCIENCESRESEARCH INSTITU
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1 Foreword by the Pro Vice-Chancell
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2 Foreword by the Research Institut
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The BMSRI Research StructureThe BMS
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BMSRI Core FacilitiesContact: Karen
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of Metabolomics, pharmacy, nutritio
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BMSRI Academic Heads new Regional N
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4. BIOMEDICAL GENOMICS RESEARCH GRO
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Recent Funding Initiatives:C-TRIC:
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Dr Mateus Webba da SilvaLecturer in
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5. BIOIMAGING RESEARCH GROUPResearc
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developmental alterations that mani
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Publications:Bigot S, Lucas L, Morr
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Publications:Barnes CA, O’Hagan B
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We also measure the genotoxic effec
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6. CANCER AND AGEING RESEARCH GROUP
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Professor Anthony P McHaleProfessor
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Professor Stephanie McKeownProfesso
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an Alzheimer Research Trust collabo
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JM, Waugh DJJ; Dexamethasone potent
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have wider applications in vivo, in
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Inter-relationships between diet an
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Flatt PR; Effective surgical treatm
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These areas are the subject of seve
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Dr YHA Abdel-WahabSenior Lecturer i
Page 52 and 53: Dr VA GaultLecturer in Molecular Bi
Page 54 and 55: McClean PL, Irwin N, Hunter K, Gaul
Page 56 and 57: Publications:Duffy NA, Green BD, Ir
Page 58 and 59: 8. MICROBIOLOGY AND BIOTECHNOLOGYRE
Page 60 and 61: Publications:Graham RJL, Graham C,
Page 62 and 63: analyses. However there is still a
Page 64 and 65: Plessas S, Bekatorou A, Koutinas AA
Page 66 and 67: Biochemical studies/ viral evasion
Page 68 and 69: Dr Stephen McCleanLecturer in Prote
Page 70 and 71: environmental remediation and as ro
Page 72 and 73: 9. NORTHERN IRELAND CENTRE FOR FOOD
Page 74 and 75: 26-28 Sept 2007: International Seaf
Page 76 and 77: Dr Barnes has developed expertise i
Page 78 and 79: Dr Alison GallagherSenior Lecturer
Page 80 and 81: In addition, results of a pilot stu
Page 82 and 83: Dr Maeve KerrResearch AssociateCont
Page 84 and 85: Memberships of External Committees/
Page 86 and 87: Indicators of Esteem:Professor McNu
Page 88 and 89: were examined. The intervention and
Page 90 and 91: Within this work both short-term an
Page 92 and 93: micronutrient supplementation at a
Page 94 and 95: 10. STEM CELL & EPIGENETICS RESEARC
Page 96 and 97: Publications:Lees-Murdock DJ, Lau H
Page 98 and 99: Publications:Lees-Murdock DJ, Lau H
Page 100 and 101: 11. SYSTEMS BIOLOGY RESEARCH GROUPT
Page 104 and 105: Dr Daniel BerrarLecturer in Biomedi
Page 106 and 107: Zhang et al; Incorporating Feature
Page 108 and 109: Bala P, Baldridge K, Benfenati E, C
Page 110 and 111: In addition there is a growing them
Page 112 and 113: Clinical work involves development
Page 114 and 115: In 2009 he was appointed Chairman o
Page 116 and 117: Stevenson TR, Goodall EA and Moore
Page 118 and 119: Dr Raymond BeirneLecturer in Optome
Page 120 and 121: Dr Julie McClellandLecturer in Opto
Page 122 and 123: Graham JE, Moore JE, Moore JE, McCl
Page 124 and 125: Research Staff:Dr David OrrSenior R
Page 126 and 127: Dr Victoria McGilliganResearch Asso
Page 128 and 129: 13. Externally Funded Projects duri
Page 130 and 131: Grant Holder Anderson, Prof RSFundi
Page 132 and 133: Funding Body Royal Irish AcademyAmo
Page 134 and 135: 14. BIOMEDICAL SCIENCES RESEARCH IN
Page 136 and 137: Student: Simon GenglerTitle: Effect
Page 138 and 139: Student: Anisha MazumdarTitle: Anal
Page 140 and 141: Student: Clare RyanTitle: How does
Page 142 and 143: CONGRATULATIONS TO THE FOLLOWING PO
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