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Dr Stephen McCleanLecturer in ProteomicsContact details:T: +44 (0)28 70324406s.mcclean@ulster.ac.ukBrief profile:Dr Stephen McClean obtained undergraduate, Masters and PhD degrees from the University of Ulster and held aresearch position there before becoming a Lecturer in Proteomics in December 2001.Main research interests:As an analytical chemist he has broad interest in the application of chromatography and mass spectrometrictechnologies to the analysis of a range of molecules in biological matrices.Of particular interest is the application of ion trap, MALDI-TOF and QToF MS/MS to the isolation and characterizationof novel peptides from amphibian skin secretions, in particular those from the tiger leg monkey frog Phyllomedusahypochondrialis azurea. The characterization and bioactivity testing of molecules from other amphibian skin secretions,reptile and arachnid venoms also fall within the remit of this research. QTOF MS/MS de novo peptide sequencing hasbeen successfully applied to the determination of novel peptide structures in these matrices.A T_ PHY P_ NEW _ 1 8 0 _ 7 2 _ 1 0 0 8 0 8 _ 1 5 8 9 Ma x En t 3 9 3 [Ev - 3 7 2 5 4 ,It5 0 ,En 1 ] ( 0 .0 5 0 ,2 0 0 .0 0 ,0 .2 0 0 ,1 4 0 0 .0 0 ,2 ,C mp ) 1 : TO F MS MS 7 9 5 .5 0 ES +1 0 0L G P A L I TR K P L K G K P b Ma xPK G K L PK R T I L A P G L y Ma x1 4 7 3 .9 9b 1 41 5 8 9 .0 6 ( M +H ) +%01 2 8 8 .9 1b 1 27 3 7 .5 73 1 4 .2 3 4 2 4 .3 01 4 7 5 .0 91 0 4 7 .7 96 5 2 .4 9 7 9 5 .1 2 9 0 9 .6 21 8 6 .1 3a 51 1 7 5 .8 11 3 6 0 .8 51 0 2 2 .7 1 b 1 01 5 8 9 .9 11 5 8 .9 46 4 4 .9 1M/z1 0 0 2 0 0 3 0 0 4 0 0 5 0 0 6 0 0 7 0 0 8 0 0 9 0 0 1 0 0 0 1 1 0 0 1 2 0 0 1 3 0 0 1 4 0 0 1 5 0 0 1 6 0 0He has also studied the profiling of anti-depressent and anti-psychotic agents in human hair samples using ion trapmultiple stage mass spectrometry compared with QToF MS/MS to elucidate fragmentation pathways for selecteddrugs and metabolites.Esteem indicators:Stephen has over 40 peer-reviewed publications and has secured income for his research as well as undertakinganalytical consultancy work with external companies. To date he has supervised eight PhD projects to completionand is currently supervising research projects at undergraduate and postgraduate level. He is a member of theOrganising Committee of the Irish Mass Spectrometry Society, the British Mass Spectrometry Society and the RoyalSociety of Chemistry. He is also a Member of the Editorial Board of the Open Spectroscopy Journal and acts asreviewer for the following journals: Analytica Chimica Acta, Electrophoresis, Journal of Comparative Biochemistryand Physiology, Proteomics and Rapid Communications in Mass Spectrometry.During the year Stephen was invited to deliver a presentation entitled: “QTOF MS/MS de novo sequencing of naturallyoccurring peptides” at the Irish Mass Spectrometry Society Proteomics Meeting, Food Research Centre, Ashtown,66
Dublin (in November 2007) and he was also Chair of the afternoon session of Irish Mass Spectrometry SocietyConference, in Dublin (May 2008).Publication:Thompson AH, Bjourson AJ, Orr DF, Shaw C and McClean S; Amphibian skin secretomics: application of parallelquadrupole time-of-flight mass spectrometry and peptide precursor cDNA cloning to rapidly characterize the skinsecretory peptidome of Phyllomedusa hypochondrialis azurea: discovery of a novel peptide family, the hyposins;Journal of Proteome Research, 6: 3604 –3613, 2007Dr Poonam Singh (nee Nigam)Senior Lecturer in BiotechnologyContact details:T: +44 (0)28 70324053p.singh@ulster.ac.ukIndicators of esteemDr Singh (nee Nigam) is currently an Associate Advisor in the Biotechnology British Council. She is also acted asan External Examiner PhD student viva at Manchester University (Ms Castelo sponsored by European CommissionMarie Curie Fellowship for early stage Research Training Program).Dr Singh was invited to give the following lectures at international conferences:“Bioremediation of Textile waste water through solid state fermentation systems”, at the International Conference on NewHorizons in Biotechnology Trivandrum, India (26-29 November 2007 – IL, 26: 047, 2007).“Studies on Encapsulated and entrapped yeast for Bioethanol production”, Biospectrum, International Symposium onAdvances in Food Biotechnology & Nutrition, (30 Nov-1 Dec 2007), Mar Athanasios College for Advanced Studies,Tiruvalla, Kerala, India (pp. 25-26: LL-06, 2007).Publications:Genest S, Kerr C, Shah A, Rahman MM, Naser GMM, Nigam P, Nahar L, Sarker SD; Comparative Bioactivity Studies onTwo Mimosa Species; The Latin American And Caribbean Bulletin of Medicinal And Aromatic Plants (BLACPMA Derechos dePublicación © 2008 Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, 7: 38–43, 2008Robinson T & Nigam P; Remediation of textile dye-waste water using a white rot fungus Bjerkandera adusta throughsolid-state fermentation (SSF); Applied Biochemistry and Biotechnology, 151: 618-628, 2008Dr Nigel TernanLecturer in Microbial ProteomicsContact details:T: +44 (0)28 70323063ng.ternan@ulster.ac.ukDr Nigel Ternan gained his Ph.D. from Queen’s University Belfast (1997) and was apointed to a lectureship inMicrobiology at the University of Ulster in 2003, having previously held the position of Research Fellow at UU.He has previously investigated the catalytic activities of novel microbial enzymes from the point of view of both67
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BIOMEDICAL SCIENCESRESEARCH INSTITU
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1 Foreword by the Pro Vice-Chancell
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2 Foreword by the Research Institut
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The BMSRI Research StructureThe BMS
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BMSRI Core FacilitiesContact: Karen
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of Metabolomics, pharmacy, nutritio
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BMSRI Academic Heads new Regional N
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4. BIOMEDICAL GENOMICS RESEARCH GRO
Page 18 and 19: Recent Funding Initiatives:C-TRIC:
Page 20 and 21: Dr Mateus Webba da SilvaLecturer in
Page 22 and 23: 5. BIOIMAGING RESEARCH GROUPResearc
Page 24 and 25: developmental alterations that mani
Page 26 and 27: Publications:Bigot S, Lucas L, Morr
Page 28 and 29: Publications:Barnes CA, O’Hagan B
Page 30 and 31: We also measure the genotoxic effec
Page 32 and 33: 6. CANCER AND AGEING RESEARCH GROUP
Page 34 and 35: Professor Anthony P McHaleProfessor
Page 36 and 37: Professor Stephanie McKeownProfesso
Page 38 and 39: an Alzheimer Research Trust collabo
Page 40 and 41: JM, Waugh DJJ; Dexamethasone potent
Page 42 and 43: have wider applications in vivo, in
Page 44 and 45: Inter-relationships between diet an
Page 46 and 47: Flatt PR; Effective surgical treatm
Page 48 and 49: These areas are the subject of seve
Page 50 and 51: Dr YHA Abdel-WahabSenior Lecturer i
Page 52 and 53: Dr VA GaultLecturer in Molecular Bi
Page 54 and 55: McClean PL, Irwin N, Hunter K, Gaul
Page 56 and 57: Publications:Duffy NA, Green BD, Ir
Page 58 and 59: 8. MICROBIOLOGY AND BIOTECHNOLOGYRE
Page 60 and 61: Publications:Graham RJL, Graham C,
Page 62 and 63: analyses. However there is still a
Page 64 and 65: Plessas S, Bekatorou A, Koutinas AA
Page 66 and 67: Biochemical studies/ viral evasion
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Page 72 and 73: 9. NORTHERN IRELAND CENTRE FOR FOOD
Page 74 and 75: 26-28 Sept 2007: International Seaf
Page 76 and 77: Dr Barnes has developed expertise i
Page 78 and 79: Dr Alison GallagherSenior Lecturer
Page 80 and 81: In addition, results of a pilot stu
Page 82 and 83: Dr Maeve KerrResearch AssociateCont
Page 84 and 85: Memberships of External Committees/
Page 86 and 87: Indicators of Esteem:Professor McNu
Page 88 and 89: were examined. The intervention and
Page 90 and 91: Within this work both short-term an
Page 92 and 93: micronutrient supplementation at a
Page 94 and 95: 10. STEM CELL & EPIGENETICS RESEARC
Page 96 and 97: Publications:Lees-Murdock DJ, Lau H
Page 98 and 99: Publications:Lees-Murdock DJ, Lau H
Page 100 and 101: 11. SYSTEMS BIOLOGY RESEARCH GROUPT
Page 102 and 103: Kravtsov V, Swain M, Schuster A, Du
Page 104 and 105: Dr Daniel BerrarLecturer in Biomedi
Page 106 and 107: Zhang et al; Incorporating Feature
Page 108 and 109: Bala P, Baldridge K, Benfenati E, C
Page 110 and 111: In addition there is a growing them
Page 112 and 113: Clinical work involves development
Page 114 and 115: In 2009 he was appointed Chairman o
Page 116 and 117: Stevenson TR, Goodall EA and Moore
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Dr Raymond BeirneLecturer in Optome
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Dr Julie McClellandLecturer in Opto
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Graham JE, Moore JE, Moore JE, McCl
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Research Staff:Dr David OrrSenior R
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Dr Victoria McGilliganResearch Asso
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13. Externally Funded Projects duri
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Grant Holder Anderson, Prof RSFundi
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Funding Body Royal Irish AcademyAmo
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14. BIOMEDICAL SCIENCES RESEARCH IN
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Student: Simon GenglerTitle: Effect
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Student: Anisha MazumdarTitle: Anal
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Student: Clare RyanTitle: How does
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CONGRATULATIONS TO THE FOLLOWING PO
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