biomedical sciences research institute - Research - University of Ulster

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Plessas S, Bekatorou A, Koutinas AA, Soupioni M, Banat IM and Marchant R; Use of Saccharomyces cerevisiaecells immobilized on orange peel as biocatalyst for alcoholic fermentation; Bioresource Technology, 98: 860-865, 2007Plessas S, Bekatorou A, Kanellaki M, Koutinas AA, Marchant R and Banat IM; Use of immobilized cell biocatalysts inbaking; Process Biochemistry, 42: 1244-1249, 2007Marchant R, Franzetti A, Pavlostathis SG, Okutman Tas D, Erdbrűgger I, Űnyayar A, Mazmanci MA, Banat IM;Thermophilic bacteria in cool temperate soils: are they metabolically active or continually added by globalatmospheric transport; Applied Microbiology and Biotechnology, 5: 841-852, 2008Plessas S, Koliopoulos D, Kourkoutas Y, Psarianos C, Alexopoulos A, Marchant R, Banat IM and Koutinas AA;Upgrading of discarded oranges through fermentation using kefir in food industry; Food Chemistry, 106, 40-49, 2008Plessas S; Bosnea L; Psarianos, Koutinas AA, Marchant R & Banat IM; Lactic acid production by mixed culturesof Kluyveromyces marxianus, Lactobacillus delbrueckii ssp bulgaricus and Lactobacillus helventicus; BioresourceTechnology 99: 5951-5955, 2008Professor W. Franklin SmythProfessor of Bio-Analytical ChemistryContact details:T: +44 (0)28 70324425wf.smyth@ulster.ac.ukProfessor Franklin Smyth is Professor of Bioanalytical Chemistry whose research interests lie in the general area ofidentification and determination of low molecular mass organic molecules of biological importance, such as naturalproducts in plants and synthetic drugs in biological matrices.Professor Smyth’s main research interests are:(a)(b)metabolomic investigations of natural products, biological activity-testing and structural characterisation of plantsubstances with potential medicinal significance, particularly those that have antibacterial potential; anddevelopment of mass spectrometric assays for psycho-active drugs in hair and saliva samples.Franklin is using LC-ESI-ion trap mass spectrometry and LC-ESI-QToF mass spectrometry in metabolomicinvestigations of natural products and the development of mass spectrometric assays for psycho-active drugs.62
He has developed a research link with Dr Peter Brooks (University of The Sunshine Coast, Queensland, Australia) toinvestigate the isolation and characterisation of local natural product pharmaceuticals, from which technology transfercould arise in the discovery of a new anti-MRSA antibacterial, for example. Bioassay-led separation of the activecrude fractions is currently being refined using LC-ESI-MS to lead to the characterisation of individual compoundswith antibacterial activity.Suicide in Northern Ireland is the highest in the UK and it has been suggested that selective serotonin reuptakeinhibitors, which are the most widely used antidepressant drugs, are associated with an increased risk of suicidalbehaviour and self-harm. Professor Smyth, Dr Stephen McClean, Dr Bernie Doherty, Dr Virginia Rodriguez, togetherwith Professor Julian Leslie in Psychology, have developed a technique based on LC-ESI-MS that can detect earlieranti-depressant and other drug use in hair samples. It is intended that this will be used in a pilot study using hairsamples from at-risk young people in North and West Belfast. This will ultimately allow for an investigation into thepossible association between self-harm/suicide and such drugs in these regions.PublicationsDoherty B, O’Donnell F, Smyth WF, Leslie JC, Ramachandran VN, Boyd NS, Hack CJ, O’Kane E and McClean S; A studyof the analytical behaviour of selected psycho-active drugs using liquid chromatography, ion trap mass spectrometry,gas chromatography and polarography and the construction of an appropriate database for drug characterisation;Talanta, 72: 755–761, 2007Doherty B, Rodriguez V, Leslie JC, McClean S and Smyth WF; An ESI- MS/MS investigation of selected psychoactivepharmaceuticals and its application in drug and metabolite profiling by LC-ESI-MS/MS; Rapid Communications in MassSpectrometry, 21: 2031-2038, 2007Smyth WF and Rodriguez V; Recent studies of the electrospray ionisation behaviour of selected drugs and theirapplication in capillary electrophoresis mass spectrometry and liquid chromatography-mass spectrometry; Journal ofChromatography A, 1159: 159-174, 2007Smyth TJ, Ramachandran VN, McGuigan A, Hopps J and Smyth WF; The Characterisation of Nicotine and RelatedCompounds using Electrospray Ionisation with Ion Trap Mass Spectrometry and with Quadrupole Time of Flight MassSpectrometry and their detection by LC-ESI-MS; Rapid Communications in Mass Spectrometry, 21: 557-566, 2007Dr Anne BridgenLecturer in BioimagingContact details:T: +44 (0)28 70324903a.bridgen@ulster.ac.ukDr Bridgen’s research focuses on the molecular biology of a group of exotic viruses, the Bunyaviridae, some of whichare severe pathogens of man and animals. They are negative sense, tri-segmented RNA viruses that are carried by avariety of (mainly) arthropod vectors, particularly ticks and mosquitoes. Her research focuses on three main areas:Pathogenesis of the diseaseDr Bridgen has studied the effects on wild type and immune deficient mice infected with a relatively apathogenicvirus, Dugbe virus in collaboration with Professor John Fazakerley in Edinburgh funded by the Royal Society. Annecontinues to work on a research project in collaboration with Dr Michael Baron of the Institute of Animal Health inPirbright (IAH) with funding awarded by the BBSRC to study one of the serious pathogens in this virus group, Nairobisheep disease virus, using the special containment facilities available at the IAH.63
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BIOMEDICAL SCIENCESRESEARCH INSTITU
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1 Foreword by the Pro Vice-Chancell
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2 Foreword by the Research Institut
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The BMSRI Research StructureThe BMS
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BMSRI Core FacilitiesContact: Karen
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of Metabolomics, pharmacy, nutritio
Page 14 and 15: BMSRI Academic Heads new Regional N
Page 16 and 17: 4. BIOMEDICAL GENOMICS RESEARCH GRO
Page 18 and 19: Recent Funding Initiatives:C-TRIC:
Page 20 and 21: Dr Mateus Webba da SilvaLecturer in
Page 22 and 23: 5. BIOIMAGING RESEARCH GROUPResearc
Page 24 and 25: developmental alterations that mani
Page 26 and 27: Publications:Bigot S, Lucas L, Morr
Page 28 and 29: Publications:Barnes CA, O’Hagan B
Page 30 and 31: We also measure the genotoxic effec
Page 32 and 33: 6. CANCER AND AGEING RESEARCH GROUP
Page 34 and 35: Professor Anthony P McHaleProfessor
Page 36 and 37: Professor Stephanie McKeownProfesso
Page 38 and 39: an Alzheimer Research Trust collabo
Page 40 and 41: JM, Waugh DJJ; Dexamethasone potent
Page 42 and 43: have wider applications in vivo, in
Page 44 and 45: Inter-relationships between diet an
Page 46 and 47: Flatt PR; Effective surgical treatm
Page 48 and 49: These areas are the subject of seve
Page 50 and 51: Dr YHA Abdel-WahabSenior Lecturer i
Page 52 and 53: Dr VA GaultLecturer in Molecular Bi
Page 54 and 55: McClean PL, Irwin N, Hunter K, Gaul
Page 56 and 57: Publications:Duffy NA, Green BD, Ir
Page 58 and 59: 8. MICROBIOLOGY AND BIOTECHNOLOGYRE
Page 60 and 61: Publications:Graham RJL, Graham C,
Page 62 and 63: analyses. However there is still a
Page 66 and 67: Biochemical studies/ viral evasion
Page 68 and 69: Dr Stephen McCleanLecturer in Prote
Page 70 and 71: environmental remediation and as ro
Page 72 and 73: 9. NORTHERN IRELAND CENTRE FOR FOOD
Page 74 and 75: 26-28 Sept 2007: International Seaf
Page 76 and 77: Dr Barnes has developed expertise i
Page 78 and 79: Dr Alison GallagherSenior Lecturer
Page 80 and 81: In addition, results of a pilot stu
Page 82 and 83: Dr Maeve KerrResearch AssociateCont
Page 84 and 85: Memberships of External Committees/
Page 86 and 87: Indicators of Esteem:Professor McNu
Page 88 and 89: were examined. The intervention and
Page 90 and 91: Within this work both short-term an
Page 92 and 93: micronutrient supplementation at a
Page 94 and 95: 10. STEM CELL & EPIGENETICS RESEARC
Page 96 and 97: Publications:Lees-Murdock DJ, Lau H
Page 98 and 99: Publications:Lees-Murdock DJ, Lau H
Page 100 and 101: 11. SYSTEMS BIOLOGY RESEARCH GROUPT
Page 102 and 103: Kravtsov V, Swain M, Schuster A, Du
Page 104 and 105: Dr Daniel BerrarLecturer in Biomedi
Page 106 and 107: Zhang et al; Incorporating Feature
Page 108 and 109: Bala P, Baldridge K, Benfenati E, C
Page 110 and 111: In addition there is a growing them
Page 112 and 113: Clinical work involves development
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In 2009 he was appointed Chairman o
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Stevenson TR, Goodall EA and Moore
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Dr Raymond BeirneLecturer in Optome
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Dr Julie McClellandLecturer in Opto
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Graham JE, Moore JE, Moore JE, McCl
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Research Staff:Dr David OrrSenior R
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Dr Victoria McGilliganResearch Asso
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13. Externally Funded Projects duri
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Grant Holder Anderson, Prof RSFundi
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Funding Body Royal Irish AcademyAmo
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14. BIOMEDICAL SCIENCES RESEARCH IN
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Student: Simon GenglerTitle: Effect
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Student: Anisha MazumdarTitle: Anal
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Student: Clare RyanTitle: How does
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CONGRATULATIONS TO THE FOLLOWING PO
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