biomedical sciences research institute - Research - University of Ulster

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We also measure the genotoxic effects of nanoparticles using the comet assay in relation to size and atomiccomposition.(a) Hela cells and 250nm silica nanoparticles, (b) ceria (CeO 2) nanoparticles taken up by a (c) plain ceria nanoparticles3T3 fibroblast cell,Part of this work was presented at the Annual Meeting of NanoInteract (Development of a platform and toolkit forunderstanding interactions between nanoparticles and the living world) in Lodz, Poland, 14 th /15 th of March 2008.Nanoparticles and electromagnetic RadiationElectromagnetic radiation and matter interact predominantly by three different mechanisms: Comptonscattering, photoelectric effect and pair production. We are interested in photoelectrons produced bynanoparticles and their impact on biological systems. Monte-Carlo Simulations show a 25,000 fold increaseof secondary electrons of a 2nm gold particle compared to the mass-equivalent 2cm particle.Secondary electron production by 10 keV primary photons within the target and escaping electrons overlayed by the target geometry for water(a), gold (b) and uranium (c). Figure (d)-(f) shows the corresponding energy deposition.Preliminary results were presented on the ESF-EMBO Symposium, 3 rd -8 th November 2007, Spain (Probing Interactionsbetween Nanoparticles/Biomaterials and Biological Systems – Alternative Approaches to Bio- and Nano-safety) and onthe Second Meeting of NanoInteract (Development of a platform and toolkit for understanding interactions betweennanoparticles and the living world), 9 th November 2007, Spain.Publications:Barnes CA, Elsaesser A, Arkusz J, Smok A, Palus J, Lesniak A, Salvati A, Hanrahan JP, Jong WH, Dziubaltowska E, StepnikM, Rydzynski K, McKerr G, Lynch I, Dawson KA and Howard CV; Reproducible Comet Assay of Amorphous SilicaNanoparticles Detects No Genotoxicity, Nano Lett , 8: 3069-3074, 2008Samsonov D, Elsaesser A, Edwards A, Thomas HM, Morfill GE; High speed laser tomography system; Review of ScientificInstruments, 79: 35102, Mar 200828
INDICATORS OF ESTEEMMembership of External Committees/Professional Bodies (Howard):• President: International Society of Doctors for the Environment 2007-2008• Elected Fellow of the Collegium Ramazzini, Carpi, Italy• Honorary Life Fellow: International Society for Stereology• Fellow of the Royal College of Pathologists• Member British Society of Toxicological Pathologists• Member: European Teratology Society• Member of DEFRA ACP (Advisory Committee on Pesticides) 2003-2008• Member of the Medical and Toxicology Panel of the ACP• Member DETI Advanced Materials Panel• Member Northern Ireland Tumour Bank Working Group• Editorial board, Journal of Microscopy• International Editorial Advisory Board, Forma• Editorial board, Electronic Journal of Pathology and HistologyInvitations to speak (Howard)5 th October 2007 – Invited speaker FEI debate on ‘Nanotechnology in food production’5 th -9 th November 2007 – Invited speaker European Science Foundation/EMBO conference on nantotoxicology StFeliu, Spain.30 th November 2007 – Invited to address the Council of Europe, Paris on “Chemical Risk Assessment – an antidoteto precaution?”Seminars/conferences (Soto)2007 Speaker at the colloquium: Endocrine disruptors and human health”. Argentinean association of Physicians forthe environment, August 15.2007 Discussant, Symposium on Health and Disease at The Intersection of Biology, Environment and Society, Universityof Coimbra, Portugal, October 22-23.2008 Speaker at the European Environmental Agency Symposium on “Multi-Causality and Complexity: Implicationfor Evaluating Evidence and Precautionary Prevention”, January 21-22.2008 Seminar Speaker “Does breast cancer start in the womb?” Graduate Program in Endocrinology at RutgersUniversity, Brunswick, NJ, April 4.2008 Seminar Speaker “Does breast cancer starts in the womb?” Graduate Program in Biology, Boston University,Boston, MA, April 7.2008 Speaker at the course “Communicating Complexity in Science”. Course Director: Louis Guillette. Universityof Florida at Gainesville, April 8.2008 Speaker, Gordon Research Conference on Mammary Gland Biology, Il Ciocco, Italy,June 1-62008 Special Speaker at the Dinner Panel, Gordon Research Conference on Environmental Endocrine Disruptors,Waterville Valley Resort, New Hampshire, June 8-1329
Page 1: BIOMEDICAL SCIENCESRESEARCH INSTITU
Page 4 and 5: 1 Foreword by the Pro Vice-Chancell
Page 6 and 7: 2 Foreword by the Research Institut
Page 8 and 9: The BMSRI Research StructureThe BMS
Page 10 and 11: BMSRI Core FacilitiesContact: Karen
Page 12 and 13: of Metabolomics, pharmacy, nutritio
Page 14 and 15: BMSRI Academic Heads new Regional N
Page 16 and 17: 4. BIOMEDICAL GENOMICS RESEARCH GRO
Page 18 and 19: Recent Funding Initiatives:C-TRIC:
Page 20 and 21: Dr Mateus Webba da SilvaLecturer in
Page 22 and 23: 5. BIOIMAGING RESEARCH GROUPResearc
Page 24 and 25: developmental alterations that mani
Page 26 and 27: Publications:Bigot S, Lucas L, Morr
Page 28 and 29: Publications:Barnes CA, O’Hagan B
Page 32 and 33: 6. CANCER AND AGEING RESEARCH GROUP
Page 34 and 35: Professor Anthony P McHaleProfessor
Page 36 and 37: Professor Stephanie McKeownProfesso
Page 38 and 39: an Alzheimer Research Trust collabo
Page 40 and 41: JM, Waugh DJJ; Dexamethasone potent
Page 42 and 43: have wider applications in vivo, in
Page 44 and 45: Inter-relationships between diet an
Page 46 and 47: Flatt PR; Effective surgical treatm
Page 48 and 49: These areas are the subject of seve
Page 50 and 51: Dr YHA Abdel-WahabSenior Lecturer i
Page 52 and 53: Dr VA GaultLecturer in Molecular Bi
Page 54 and 55: McClean PL, Irwin N, Hunter K, Gaul
Page 56 and 57: Publications:Duffy NA, Green BD, Ir
Page 58 and 59: 8. MICROBIOLOGY AND BIOTECHNOLOGYRE
Page 60 and 61: Publications:Graham RJL, Graham C,
Page 62 and 63: analyses. However there is still a
Page 64 and 65: Plessas S, Bekatorou A, Koutinas AA
Page 66 and 67: Biochemical studies/ viral evasion
Page 68 and 69: Dr Stephen McCleanLecturer in Prote
Page 70 and 71: environmental remediation and as ro
Page 72 and 73: 9. NORTHERN IRELAND CENTRE FOR FOOD
Page 74 and 75: 26-28 Sept 2007: International Seaf
Page 76 and 77: Dr Barnes has developed expertise i
Page 78 and 79: Dr Alison GallagherSenior Lecturer
Page 80 and 81:
In addition, results of a pilot stu
Page 82 and 83:
Dr Maeve KerrResearch AssociateCont
Page 84 and 85:
Memberships of External Committees/
Page 86 and 87:
Indicators of Esteem:Professor McNu
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were examined. The intervention and
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Within this work both short-term an
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micronutrient supplementation at a
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10. STEM CELL & EPIGENETICS RESEARC
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Publications:Lees-Murdock DJ, Lau H
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Publications:Lees-Murdock DJ, Lau H
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11. SYSTEMS BIOLOGY RESEARCH GROUPT
Page 102 and 103:
Kravtsov V, Swain M, Schuster A, Du
Page 104 and 105:
Dr Daniel BerrarLecturer in Biomedi
Page 106 and 107:
Zhang et al; Incorporating Feature
Page 108 and 109:
Bala P, Baldridge K, Benfenati E, C
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In addition there is a growing them
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Clinical work involves development
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In 2009 he was appointed Chairman o
Page 116 and 117:
Stevenson TR, Goodall EA and Moore
Page 118 and 119:
Dr Raymond BeirneLecturer in Optome
Page 120 and 121:
Dr Julie McClellandLecturer in Opto
Page 122 and 123:
Graham JE, Moore JE, Moore JE, McCl
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Research Staff:Dr David OrrSenior R
Page 126 and 127:
Dr Victoria McGilliganResearch Asso
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13. Externally Funded Projects duri
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Grant Holder Anderson, Prof RSFundi
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Funding Body Royal Irish AcademyAmo
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14. BIOMEDICAL SCIENCES RESEARCH IN
Page 136 and 137:
Student: Simon GenglerTitle: Effect
Page 138 and 139:
Student: Anisha MazumdarTitle: Anal
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Student: Clare RyanTitle: How does
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CONGRATULATIONS TO THE FOLLOWING PO
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