biomedical sciences research institute - Research - University of Ulster

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2 Foreword by the Research InstituteDirector“An Outstanding Success in the ResearchAssessment Exercise (RAE2008)”The Biomedical Sciences Research Institute (BMSRI) undertakesstrategically focused research relating to the causes, diagnosis,prevention, and treatment of human degenerative diseases,especially those with a nutritional aspect.The BMSRI is the largest Institute within the University of Ulster and currentlyaccommodates more than 235 research staff/students. The Institute offers astate of the art research environment for high profile researchers to undertakeinternationally agenda setting research in strategically important prioritisedareas of biomedicine. Our focused research strategy is supported by extensiveand complementary multidisciplinary expertise, superb infrastructure andcontemporary core technologies. Particular areas of research strength includenutrition, genomics and proteomics of disease including personalized medicinerelating to Alzheimer’s Disease, diabetes, vision, arthritis and cancer.This strategically focused approach to research has, over the last decade, beenoutstanding amongst the University of Ulster’s successes, enabling us to be awardedthe top 5* ratings in both the 1996 and 2001 Research Assessment Exercises(RAE). In the most recent RAE (2008) our Biomedical Sciences submission wasin terms of Grade Point Average, second only to King’s College London andin terms of research power we were ranked number 1 out of 69 submissionsfrom across the UK (25% 4*; 35% 3*, 35 % 2*; 5 % 1*). A brief summary of oursubmission is provided in subsequent sections of this report.“I am delighted by this result and it is a pleasure to work with such talented researchers.This reflects the dedication, discipline, high standards and hard work of all our staff. Whilewe delight in this success, it is a bond that obliges us to yet higher achievement. Futurehigh success will be best fuelled and fostered in an atmosphere of high expectation andambition. We shall continue to review our research strategy, set new challenging goals,but embedded in a supportive environment with generous mentoring and selectivenurturing of the creative talent that is the oxygen for sustainable excellence. I am veryconfident for the future - I know that our talented scientists will rise to the challengesahead and grasp opportunities as they are presented, or create new opportunitieswhere they do not yet exist.”The Biomedical Sciences Research Institute strategy is:• above all, to undertake internationally agenda-setting research in focusedareas of biomedical science;• to disseminate and publish our research outputs in the highest quality peerreviewedjournals;• where appropriate, to protect intellectual property arising from research andfacilitate translation of basic and applied research into the clinically usefulproducts for patient benefit and drive economic growth regionally, nationallyand internationally;• to actively transfer knowledge and skills to the community and develop humancapital to enable a societal and economic return on investments;• to provide leadership, influence and establish meaningful networks regionally,nationally and internationally;• to promote a culture of innovation and creativity and establish a financiallysustainable research infrastructure to enable the BMSRI to grow and thrive.4
New exciting developments this year include the completion of our new £3.9MCentre for Metabolomics, sited opposite our Centre for Molecular Bioscience.This will bring together researchers from the Diabetes, Biomedical Genomicsand our developing Pharmaceutical Science & Practice Research Groups for thestudy of complex metabolic effects. It enables the concentration of our massspectrometry expertise, combined with a NMR laboratory for further study ofmetabolite molecular structure. Our new Pharmaceutical Science & PracticeResearch Group compliments and strengthens our pharmaceutical-based researchexpertise that is already embedded in our other research groups.Our new £2M Clinical Translational Research and Innovation Centre (C-TRIC)was completed in 2008. This centre of excellence is a new purpose-built facilitylocated on the Western Health and Social Care Trust’s Altnagelvin Hospital site.The 9,000 sq ft complex is jointly operated and financially supported by Invest NI,the Western Trust, Derry City Council and the University of Ulster. It will act asa flagship for attracting investment through research and innovation in healthcareto Northern Ireland. C-TRIC aims to better “connect” the University’s researchto the clinical and research expertise within the hospital sector to ensure thatour healthcare innovations have a meaningful impact in improving the generalhealth of patients.Professor Tony Bjourson. Email: aj.bjourson@ulster.ac.uk5
Page 1: BIOMEDICAL SCIENCESRESEARCH INSTITU
Page 4 and 5: 1 Foreword by the Pro Vice-Chancell
Page 8 and 9: The BMSRI Research StructureThe BMS
Page 10 and 11: BMSRI Core FacilitiesContact: Karen
Page 12 and 13: of Metabolomics, pharmacy, nutritio
Page 14 and 15: BMSRI Academic Heads new Regional N
Page 16 and 17: 4. BIOMEDICAL GENOMICS RESEARCH GRO
Page 18 and 19: Recent Funding Initiatives:C-TRIC:
Page 20 and 21: Dr Mateus Webba da SilvaLecturer in
Page 22 and 23: 5. BIOIMAGING RESEARCH GROUPResearc
Page 24 and 25: developmental alterations that mani
Page 26 and 27: Publications:Bigot S, Lucas L, Morr
Page 28 and 29: Publications:Barnes CA, O’Hagan B
Page 30 and 31: We also measure the genotoxic effec
Page 32 and 33: 6. CANCER AND AGEING RESEARCH GROUP
Page 34 and 35: Professor Anthony P McHaleProfessor
Page 36 and 37: Professor Stephanie McKeownProfesso
Page 38 and 39: an Alzheimer Research Trust collabo
Page 40 and 41: JM, Waugh DJJ; Dexamethasone potent
Page 42 and 43: have wider applications in vivo, in
Page 44 and 45: Inter-relationships between diet an
Page 46 and 47: Flatt PR; Effective surgical treatm
Page 48 and 49: These areas are the subject of seve
Page 50 and 51: Dr YHA Abdel-WahabSenior Lecturer i
Page 52 and 53: Dr VA GaultLecturer in Molecular Bi
Page 54 and 55: McClean PL, Irwin N, Hunter K, Gaul
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Publications:Duffy NA, Green BD, Ir
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8. MICROBIOLOGY AND BIOTECHNOLOGYRE
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Publications:Graham RJL, Graham C,
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analyses. However there is still a
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Plessas S, Bekatorou A, Koutinas AA
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Biochemical studies/ viral evasion
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Dr Stephen McCleanLecturer in Prote
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environmental remediation and as ro
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9. NORTHERN IRELAND CENTRE FOR FOOD
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26-28 Sept 2007: International Seaf
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Dr Barnes has developed expertise i
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Dr Alison GallagherSenior Lecturer
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In addition, results of a pilot stu
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Dr Maeve KerrResearch AssociateCont
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Memberships of External Committees/
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Indicators of Esteem:Professor McNu
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were examined. The intervention and
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Within this work both short-term an
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micronutrient supplementation at a
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10. STEM CELL & EPIGENETICS RESEARC
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Publications:Lees-Murdock DJ, Lau H
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Publications:Lees-Murdock DJ, Lau H
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11. SYSTEMS BIOLOGY RESEARCH GROUPT
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Kravtsov V, Swain M, Schuster A, Du
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Dr Daniel BerrarLecturer in Biomedi
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Zhang et al; Incorporating Feature
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Bala P, Baldridge K, Benfenati E, C
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In addition there is a growing them
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Clinical work involves development
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In 2009 he was appointed Chairman o
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Stevenson TR, Goodall EA and Moore
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Dr Raymond BeirneLecturer in Optome
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Dr Julie McClellandLecturer in Opto
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Graham JE, Moore JE, Moore JE, McCl
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Research Staff:Dr David OrrSenior R
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Dr Victoria McGilliganResearch Asso
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13. Externally Funded Projects duri
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Grant Holder Anderson, Prof RSFundi
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Funding Body Royal Irish AcademyAmo
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14. BIOMEDICAL SCIENCES RESEARCH IN
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Student: Simon GenglerTitle: Effect
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Student: Anisha MazumdarTitle: Anal
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Student: Clare RyanTitle: How does
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CONGRATULATIONS TO THE FOLLOWING PO
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