were examined. The intervention and analyses stages <strong>of</strong> this project has been completed and to date there have beena significant number <strong>of</strong> publications associated with. It involved collaboration with CeNeS Ltd who were responsiblefor the expertise and equipment necessary for carrying out the computerised tests <strong>of</strong> cognitive function and for thecollection and collation <strong>of</strong> the resulting data. CeNeS Ltd is the sole supplier <strong>of</strong> the Cambridge NeuropsychologicalTest Automated Battery (CANTAB) which is a computerised battery <strong>of</strong> tests for neuropsychological evaluation.Dr O’Connor is also involved in the Northern Ireland Fish Oil Study (NIFOS) which is examining the impact <strong>of</strong> fish oilsupplementation on psychological health <strong>of</strong> older adults. It is hypothesised that marine (fish oil) n-3 polyunsaturatedfatty acids (n-3 PUFA) will modulate the immune system leading to changes in vascular blood flow to brain andthereby affecting cognitive function. There is a growing body <strong>of</strong> evidence that demonstrates that the long chain n-3PUFA, DHA is essential for cognitive development in animals and infants and children. However, to date surprisinglylittle work has been done to examine the effects <strong>of</strong> n-3 PUFA on cognitive decline in humans. The little that hasbeen reported is mainly observational work. It is proposed that the 55-70 years age group, an age group thatshows a marked increase in mild cognitive impairment, may benefit greatly from supplementation. We are currentlycarrying out a long-term (6 months) intervention study in older adults, supplementing with fish oil to investigatethe impact on psychological function. Seven Seas Ltd have kindly supplied fish oil supplements for this study whichis in collaboration with the School <strong>of</strong> Psychology at <strong>Ulster</strong>. An extension <strong>of</strong> this study is also investigating attitudestowards the use <strong>of</strong> fish oil supplements, comparing the attitudes and perceived knowledge <strong>of</strong> consumers and nonconsumers.To date there is virtually no literature on this topic, so it is hoped that this original work will identifypotential factors which might inform the decision to either supplement with fish oil or to choose not to take suchsupplements. This information is likely to be <strong>of</strong> benefit in relation to health promotion, in encouraging consumption<strong>of</strong> fish oil supplements, or to the supplement production industry.Publications:Hininger-Favier I, Andriollo-Sanchez M, Arnaud J, Meunier N, Bord S, Graham C, Polito A, Maiani G, O'Connor JM,Coudray C, Roussel AM; Age- and sex-dependent effects <strong>of</strong> long-term zinc supplementation on essential trace elementstatus and lipid metabolism in European subjects: the Zenith Study; British Journal <strong>of</strong> Nutrition, 97: 569-578, 2007Hodkinson CF, Kelly M, Alexander HD, Bradbury I, Robson PJ, Bonham MP, O’Connor JM, Coudray C, Strain JJ andWallace JM; Effect <strong>of</strong> Zinc Supplementation on the Immune Status <strong>of</strong> Healthy Older Individuals Aged 55–70 Years: theZENITH Study; Journal <strong>of</strong> Gerontology A Biol Sci Med Sci; 62: 598-608, 2007Intorre F, Polito A, Andriollo-Sanchez M, Azzini E, Raguzzini A, Toti E, Zaccaria M, Catasta G, Meunier N, Ducros V,O'Connor JM, Coudray C, Roussel AM, Maiani G; Effect <strong>of</strong> zinc supplementation on vitamin status <strong>of</strong> middle-aged andolder European adults: the ZENITH study; European Journal <strong>of</strong> Clinical Nutrition, 2007Simpson EE, McConville C, Rae G, O'Connor JM, Stewart-Knox BJ, Coudray C, Strain JJ; Salivary cortisol, stress andmood in healthy older adults: The Zenith study; Biological Psychology, 78: 1-9, 2008Stewart-Knox BJ, Simpson EE, Parr H, Rae G, Polito A, Intorre F, Andriollo Sanchez M, Meunier N, O'Connor JM,Maiani G, Coudray C, Strain JJ; Taste acuity in response to zinc supplementation in older Europeans; British Journal <strong>of</strong>Nutrition, 99:129-136, 200886
Dr Kristina PentievaSenior LecturerContact Details:T: +44 (0)28 70324675k.pentieva@ulster.ac.ukDr Pentieva is a member <strong>of</strong> Folate <strong>Research</strong> Group within NICHE. Her main <strong>research</strong> interests are in the field<strong>of</strong> folate and metabolically related B-vitamins and their role in health and disease. In particucar, she is involved ininvestigating bioavailability <strong>of</strong> different folate derivatives and the bioavailability <strong>of</strong> folate from various food matricesin healthy subjects including people with common polymorphisms for genes encoding enzymes involved in folatemetabolism. In addition, she is interested in the influence <strong>of</strong> gender, age and genotype on folate and B-vitamin statusin view <strong>of</strong> the implications for dietary recommendations for different population groups and food fortification policy.Another object <strong>of</strong> her interests is the development <strong>of</strong> novel functional foods enriched with natural folates as analternative approach to fortification.Dr Pentieva is a member <strong>of</strong> The Nutrition Society (UK) and the European Academy <strong>of</strong> Nutritional Sciences.Publications:Hoey L, McNulty H, Askin N, Dunne A, Ward M, Pentieva K, Strain JJ, Molloy AM, Flynn CA, Scott JM; Impact <strong>of</strong> avoluntary food fortification policy on folate, related B-vitamin status and homocysteine in healthy adults; AmericanJournal <strong>of</strong> Clinical Nutrition, 86:1405-1413, 2007McNulty H, Pentieva K, Hoey L and Ward W; Folic acid and related B-vitamins in disease prevention; Food Science andTechnology; 21: 41-43, 2007Bekaert B, Cooper ML, Green F, McNulty H, Pentieva K, Scott JM, Molloy AM, Rayman MP; Effect <strong>of</strong> selenium statusand supplementation with high-selenium yeast on plasma homocysteine and B vitamin concentrations in the UKelderly; Molecular Nutrition and Food <strong>Research</strong>, 52: 1324-1333, 2008Dickey W, Ward M, Whittle CR, Kelly MT, Pentieva K, Horigan G, Patton S, McNulty H; Homocysteine and relatedB-vitamin status in celiac disease: effects <strong>of</strong> gluten exclusion and histological recovery; Scandinavian Journal <strong>of</strong>gastroenterology, 43: 682-688, 2008McNulty H, Pentieva K, Hoey L and Ward W; Homocysteine, B-vitamins and CVD; Proceedings <strong>of</strong> the Nutrition Society,67: 232-237, 2008Dr Ruth Price<strong>Research</strong> AssociateContact Details:T: +44 (0)28 70323515rk.price@ulster.ac.ukDr Price has been a member <strong>of</strong> NICHE since 2000, and her main <strong>research</strong> interest is in the area <strong>of</strong> wholegrains andheath. She is currently the lead <strong>research</strong>er on the EU-funded Integrated Project “Healthgrain– exploiting bioactivity <strong>of</strong>European cereal grains for improved nutrition and health benefits”. The aim <strong>of</strong> this work is to increase understanding<strong>of</strong> the mechanisms whereby minor components present in cereals (particularly wholegrain wheat foods) impacton human physiology, and thus may contribute to the prevention or alleviation <strong>of</strong> heart disease and other diseases.87
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BIOMEDICAL SCIENCESRESEARCH INSTITU
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1 Foreword by the Pro Vice-Chancell
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2 Foreword by the Research Institut
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The BMSRI Research StructureThe BMS
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BMSRI Core FacilitiesContact: Karen
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of Metabolomics, pharmacy, nutritio
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BMSRI Academic Heads new Regional N
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4. BIOMEDICAL GENOMICS RESEARCH GRO
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Recent Funding Initiatives:C-TRIC:
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Dr Mateus Webba da SilvaLecturer in
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5. BIOIMAGING RESEARCH GROUPResearc
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developmental alterations that mani
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Publications:Bigot S, Lucas L, Morr
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Publications:Barnes CA, O’Hagan B
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We also measure the genotoxic effec
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6. CANCER AND AGEING RESEARCH GROUP
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Professor Anthony P McHaleProfessor
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Professor Stephanie McKeownProfesso
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Student: Anisha MazumdarTitle: Anal
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Student: Clare RyanTitle: How does
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CONGRATULATIONS TO THE FOLLOWING PO